1994
DOI: 10.1182/blood.v83.3.641.bloodjournal833641
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Clonal, nonconstitutional rearrangements of the MLL gene in infant twins with acute lymphoblastic leukemia: in utero chromosome rearrangement of 11q23

Abstract: Rearrangements of chromosome band 11q23 are common in infant leukemias, comprising more than 70% of the observed chromosome abnormalities in children less than 1 year of age. The MLL gene, which is located at the 11q23 breakpoint in infant, childhood, and adult acute leukemias, has been cloned and has homology to the Drosophila trithorax gene. The breakpoints in MLL are restricted to an 8.3-kilobase pair (kb) region of the gene that is involved in translocations with as many as 29 other chromosomal regions in … Show more

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Cited by 19 publications
(16 citation statements)
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“…Recent studies suggest that a hallmark genetic event for acute leukemias, a chromosomal translocation, can be initiated in utero 45–50. Birth weight is, in part, a result of the intrauterine environment and has been associated with several growth factors, including insulin‐like growth factor‐I (IGF‐1), sex‐steroid hormones, and insulin‐like growth factor II (IGF‐1I) 51, 52 .…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies suggest that a hallmark genetic event for acute leukemias, a chromosomal translocation, can be initiated in utero 45–50. Birth weight is, in part, a result of the intrauterine environment and has been associated with several growth factors, including insulin‐like growth factor‐I (IGF‐1), sex‐steroid hormones, and insulin‐like growth factor II (IGF‐1I) 51, 52 .…”
Section: Discussionmentioning
confidence: 99%
“…Several sophisticated epidemiological and molecular genetic studies, together with retrospective analysis of neonatal blood spots (Guthrie cards), have demonstrated that infant leukaemias, especially those harbouring MLL rearrangements, arise during fetal development. Their very brief latencies suggest that, besides the oncogeneic properties of MLL fusion genes, very rapid acquisition of any additional chromosomal damage is necessary to cause overt disease (Ford et al , 1993; Gill Super et al , 1994; Greaves, 1996; Biondi et al , 2000; Eguchi et al , 2006).…”
Section: Discussionmentioning
confidence: 99%
“…It is well known that the cytogenetic characteristics of acute leukemia in identical twins are the same, and they often show similar clinical courses (8–10). Both of our cases showed AML with the chromosomal abnormality t(1;11)(q21;q13) and rearrangement of the MLL gene.…”
Section: Discussionmentioning
confidence: 99%