Clonal organization in the postnatal mouse central nervous system is prefigured in the embryonic neuroepithelium

Mathis, Luc; Nicolas, Jean‐François

doi:10.1002/1097-0177(2000)9999:9999<::aid-dvdy1042>3.3.co;2-c

Cited by 9 publications

(3 citation statements)

References 39 publications

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“…This observation suggested it reasonable to conclude that those cells clustered in specific layers were derived from the same cell lineage. The restricted distribution of PC cells along the anterior-posterior axis of PC appeared consistent for both neurons and glia, in agreement with the idea of a spatial conservation between related cells (Mathis and Nicolas 2000). The discrepancies reported by other authors, showing clonally related cells migrating long distances (Kirkwood et al 1992) could be due to differences in the method for clonal analysis.…”

Section: Analysis Of Cell Lineagessupporting

confidence: 88%

The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage

2017

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Abstract Piriform cortex (PC) is a 3-layer paleocortex receiving primary afferent input from the olfactory bulb. The past decade has seen significant progress in understanding the synaptic, cellular and functional organization of PC, but PC embryogenesis continues to be enigmatic. Here, using birthdating strategies and clonal analyses, we probed the early development and laminar specificity of neurogenesis/gliogenesis as it relates to the organization of the PC. Our data demonstrate a temporal sequence of laminar-specific neurogenesis following the canonical “inside-out” pattern, with the notable exception of PC Layer II which exhibited an inverse “outside-in” temporal neurogenic pattern. Of interest, we found no evidence of a neurogenic gradient along the anterior to posterior axis, although the timing of neuronal migration and laminar development was delayed rostrally by approximately 24 h. To begin probing if lineage affected cell fate in the PC, we labeled PC neuroblasts using a multicolor technique and analyzed their laminar organization. Our results suggested that PC progenitors were phenotypically committed to reach specific layers early in the development. Collectively, these studies shed new light on the determinants of the laminar specificity of neuronal/glial organization in PC and the likely role of subpopulations of committed progenitors in regulating PC embryogenesis.

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Section: Analysis Of Cell Lineagessupporting

confidence: 88%

The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage

2017

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“…Evidence for bipotent mesoderm and neurectoderm-generating progenitors had been acquired in the past from single cell labeling experiments in the mouse (Forlani et al, 2003; Lawson et al, 1991). The contribution of posterior stem cell-like cells to the notochord (Selleck and Stern, 1991; Stern et al, 1992), the somites (Selleck and Stern, 1991; Stern et al, 1992), and the neural tube (Mathis and Nicolas, 2000a; Mathis and Nicolas, 2000b; Mathis and Nicolas, 2003) had also been reported.…”

Section: A Function For Hox and Caudal-related Genes In Axial Growthmentioning

confidence: 94%

Hox genes and regional patterning of the vertebrate body plan

Mallo

Wellik

Deschamps

2010

Developmental Biology

467

397

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Several decades have passed since the discovery of Hox genes in the fruit fly Drosophila melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) axis (Lewis, 1978) earned them well-deserved attention as important regulators of embryonic development. Phenotypes due to loss- and gain-of-function mutations in mouse Hox genes have revealed that the spatiotemporally controlled expression of these genes is critical for the correct morphogenesis of embryonic axial structures. Here, we review recent novel insight into the modalities of Hox protein function in imparting specific identity to anatomical regions of the vertebral column, and in controlling the emergence of these tissues concomitantly with providing them with axial identity. The control of these functions must have been intimately linked to the shaping of the body plan during evolution.

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“…Single progenitors or clusters of progenitors can be labeled by genetically engineered retroviruses or germlinetransmitted genetic insertions. This has provided information on the number of progenitors giving rise to a given brain region and the types of neurons derived from single progenitors (Cepko, 1988;Sanes, 1989Sanes, , 1994Miyake et al, 1993;Baader et al, 1996;Goldman et al, 1997;Mathis et al, 1997;Mathis and Nicolas, 2000, 2003. As general fate-mapping tools, however, these particular techniques suffer from limitations in targeting (random progenitors are labeled) as well as in scope (few or scattered progenitors are labeled).…”

Section: Introductionmentioning

confidence: 99%

Fate-Mapping the Mammalian Hindbrain: Segmental Origins of Vestibular Projection Neurons Assessed Using Rhombomere-SpecificHoxa2Enhancer Elements in the Mouse Embryo

Pasqualetti¹,

Dı́az²,

Renaud³

et al. 2007

J. Neurosci.

121

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As a step toward generating a fate map of identified neuron populations in the mammalian hindbrain, we assessed the contributions of individual rhombomeres to the vestibular nuclear complex, a major sensorimotor area that spans the entire rhombencephalon. Transgenic mice harboring either the lacZ or the enhanced green fluorescent protein reporter genes under the transcriptional control of rhombomere-specific Hoxa2 enhancer elements were used to visualize rhombomere-derived domains. We labeled functionally identifiable vestibular projection neuron groups retrogradely with conjugated dextran-amines at successive embryonic stages and obtained developmental fate maps through direct comparison with the rhombomere-derived domains in the same embryos. The fate maps show that each vestibular neuron group derives from a unique rostrocaudal domain that is relatively stable developmentally, suggesting that anteroposterior migration is not a major contributor to the rostrocaudal patterning of the vestibular system. Most of the groups are multisegmental in origin, and each rhombomere is fated to give rise to two or more vestibular projection neuron types, in a complex pattern that is not segmentally iterated. Comparison with studies in the chicken embryo shows that the rostrocaudal patterning of identified vestibular projection neuron groups is generally well conserved between avians and mammalians but that significant speciesspecific differences exist in the rostrocaudal limits of particular groups. This mammalian hindbrain fate map can be used as the basis for targeting genetic manipulation to specific subpopulations of vestibular projection neurons.

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Clonal organization in the postnatal mouse central nervous system is prefigured in the embryonic neuroepithelium

Cited by 9 publications

References 39 publications

The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage

The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage

Hox genes and regional patterning of the vertebrate body plan

Fate-Mapping the Mammalian Hindbrain: Segmental Origins of Vestibular Projection Neurons Assessed Using Rhombomere-SpecificHoxa2Enhancer Elements in the Mouse Embryo

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