2009
DOI: 10.3892/ijo_00000382
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Clonal proliferation of HTLV-1-infected cells is associated with spontaneous malignant tumor formation in mice

Abstract: Abstract. Adult T-cell leukemia/lymphoma (ATL) is characterized by monoclonal proliferation of tumor cells that harbor integrated human T-cell leukemia virus type-1 (HTLV-1). These malignant cells accumulate in various organs including the liver, spleen and skin in addition to blood and lymph nodes. Although there have been several reports of animal models of HTLV-1 infection in which proviral distribution has been examined, clonal expansion of the experimentally infected host cells has not been extensively an… Show more

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Cited by 2 publications
(1 citation statement)
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“…However, there have been several reports on HTLV-1 infection in mice in which clonal proliferation of HTLV-1 has been associated with spontaneous malignant tumor formation (20). Regarding these data, histiocytic sarcoma invasion into the lumbar spinal cord has been described in transgenic mice that developed HAM/TSP-like disease supporting the oncogenic feature of HTLV-1 (1, 21).…”
Section: Background and Discussionmentioning
confidence: 99%
“…However, there have been several reports on HTLV-1 infection in mice in which clonal proliferation of HTLV-1 has been associated with spontaneous malignant tumor formation (20). Regarding these data, histiocytic sarcoma invasion into the lumbar spinal cord has been described in transgenic mice that developed HAM/TSP-like disease supporting the oncogenic feature of HTLV-1 (1, 21).…”
Section: Background and Discussionmentioning
confidence: 99%