Clonal relationship between infiltrating immunoglobulin G4 (IgG4)-positive plasma cells in lacrimal glands and circulating IgG4-positive lymphocytes in Mikulicz's disease

Yamada, Kazunori; Kawano, Mitsuhiro; Inoüe, Ryo; Hamano, Ryoko; Kakuchi, Yasushi; Fujii, Hiroshi; Matsumura, Masami; Zen, Yoh; Takahira, Masayuki; Yachie, Akihiro; Yamagishi, Masakazu

doi:10.1111/j.1365-2249.2008.03651.x

Cited by 40 publications

(40 citation statements)

References 36 publications

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“…We found that the identical sequence of IgG4-CDR3, HLRFRGKAAPFDI in patient 1 and EFLN in patient 3, respectively, existed in salivary glands and peripheral blood (Table 4a). These results support our previous report that showed the existence of identical or genetically related clones between lacrimal glands and peripheral blood in a patient with IgG4-RD [22]. We also found that genetically related clones that had three different amino acid sequences of IgG4-CDR3 existed in salivary glands and lung tissue in patient 2 (Table 4a).…”

Section: Detection Of Identical or Genetically Related Clones Betweensupporting

confidence: 81%

“…The expression of AID is required for the process of CSR and SHM [14]. We detected AID in lacrimal glands [22] and salivary glands in patients with IgG4-RD. These data indicated that CSR may occur in the organs affected by IgG4-RD.…”

Section: Detection Of Identical or Genetically Related Clones Betweenmentioning

confidence: 78%

“…We previously showed common clones in IgG4-positive cells between lacrimal glands and peripheral blood [22]. Maillette de Buy…”

Section: Detection Of Identical or Genetically Related Clones Betweenmentioning

confidence: 99%

“…AID is expressed not only in secondary lymphoid organs but also in local tissues in salivary glands of Sjögren syndrome (SS) [16][17][18], nasal mucosa of allergic rhinitis [19,20] and bronchial asthma [21]. We previously showed AID expression in lacrimal gland of IgG4-related sialadenitis and/or dacryoadenitis and that SHM of IgG4-positive plasma cells might occur in lacrimal glands suggesting that immunoglobulin production in IgG4-related dacryoadenitis is antigen-driven [22]. However, it remains unclear whether polyclonal expansions of IgG4-positive cells and CSR in affected organs are common features of IgG4-RD.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of IgG4-positive clones in affected organs of IgG4-related disease

Kakuchi

Yamada

Ito

et al. 2016

Modern Rheumatology

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Objective. We investigated class switch reaction (CSR) in affected organs and evaluated whether the same or genetically related clones exist in IgG4-RD.Methods. We studied three patients with IgG4-RD. Total cellular RNA was extracted from salivary glands and peripheral blood, and lung tissue. Activation-induced cytidine deaminase (AID) and immunoglobulin heavy chain third complementarity determining region (IgVH-CDR3) of IgM and IgG4 were detected by reverse transcription polymerase chain reaction. We analyzed the clonal relationship of infiltrating IgG4-positive cells, as compared with IgM. We determined the existence of common clones among organs and patients.Result. AID was expressed in salivary glands of all patients and lung tissue in one. Closely Conclusion. Our results demonstrate the existence of common antigen(s) shared by patients with IgG4-RD.

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Section: Detection Of Identical or Genetically Related Clones Betweensupporting

confidence: 81%

Section: Detection Of Identical or Genetically Related Clones Betweenmentioning

confidence: 78%

“…We previously showed common clones in IgG4-positive cells between lacrimal glands and peripheral blood [22]. Maillette de Buy…”

Section: Detection Of Identical or Genetically Related Clones Betweenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of IgG4-positive clones in affected organs of IgG4-related disease

Kakuchi

Yamada

Ito

et al. 2016

Modern Rheumatology

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“…Thus, they concluded that MD is quite different from SS clinically and histopathologically. Yamada et al (12) also reported that most tissue-infiltration and circulating IgG4-positive cells in MD are polyclonal, and that the same clonally-related IgG4-positive cells exist between the lachrymal gland and peripheral blood, accounting for the clinical features of MD as an IgG4-related disease.…”

Section: B C D Amentioning

confidence: 99%

A Case of Mikulicz's Disease, IgG4-related Plasmacytic Syndrome, Successfully Treated by Corticosteroid and Mizoribine, Followed by Mizoribine Alone

et al. 2010

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We report a case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated with corticosteroid and mizoribine, followed by mizoribine alone. A 56-year-old woman experienced persistent bilateral swelling in the eyelids and submandibular region accompanied by lymphadenopathy without pain. The patient was diagnosed as having Mikulicz's disease since her bilateral lacrimal glands showed persistent swelling and biopsy specimens of the submandibular glands and lymph node showed diffuse infiltration of lymphocytes and plasma cells. Symptoms and laboratory data were improved with corticosteroids (30 mg). However, after tapering prednisolone to 5 mg, submandibular swelling developed. Adding mizoribine resulted in clinical improvement. Prednisolone was tapered and finally discontinued. Since the levels of IgG4 in peripheral blood were increased even after corticosteroid therapy and IgG4 was positive in a submandibular gland specimen obtained before the start of corticoid therapy. Thus, this case may be associated with IgG4. The present case is the first case in which mizoribine was effective for Mikulicz's disease and IgG4-related plasmacytic syndrome.

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