Clonazepam Quiets tinnitus: a randomised crossover study with<i>Ginkgo Biloba</i>

Han, Seon-Sook; Nam, Eui-Cheol; Won, Jun Yeon; Lee, Kang Uk; Wang, Chun; Choi, Hyun Kyung; Levine, Robert A.

doi:10.1136/jnnp-2012-302273

Cited by 60 publications

(40 citation statements)

References 17 publications

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“…Clonazapam has shown improvement in tinnitus in one study 41 , while another study suggests clonazepam is only effective when used in combination with Deanxit 42 . In contrast, one clinical trial determined no efficacy with Bartels 43 .…”

Section: Resultsmentioning

confidence: 99%

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Ziai¹,

Moshtaghi²,

Mahboubi³

et al. 2017

The International Tinnitus Journal

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Objectives: To review literature on the link between depression and anxiety in patients suffering from tinnitus. Method: A systematic review of published English-language literature was performed using PubMed, Ovid, and Cochrane databases. Results: Of the 56 eligible abstracts 15 were chosen to be included in the review. All articles showed an association of depression and anxiety in tinnitus patients. Conclusions: Because of the strong association between tinnitus, depression, and anxiety-all tinnitus patients should be screened for psychiatric disorders. Treatment for these complex conditions should involve a multidisciplinary team with cognitive behavioral therapy and possible pharmacological therapy.

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Section: Resultsmentioning

confidence: 99%

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Ziai¹,

Moshtaghi²,

Mahboubi³

et al. 2017

The International Tinnitus Journal

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“…However, in some studies and clinical trials it has been stated that this herb has no beneficial effect in comparison with placebo in the treatment of tinnitus (Table 2). There are many studies on the effects of Ginkgo biloba in the treatment of patients with tinnitus that most of the findings of these studies are in contrast with each other; on the one hand, some of the studies reported that Ginkgo biloba is effective in the treatment of tinnitus effective [48][49][50][51][52][53] and on the other hand other studies referred to it as ineffective herbal medicine 28,[54][55][56][57] . The results of a systematic review showed that Ginkgo biloba is little/less effective in the treatment of tinnitus.…”

Section: Resultsmentioning

confidence: 61%

Ginkgo biloba in the treatment of tinnitus: An updated literature review

Mahmoudian-Sani¹,

Hashemzadeh‐Chaleshtori²,

Asadi-Samani³

et al. 2017

The International Tinnitus Journal

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Introduction: Tinnitus is one of the common diseases of the ear that is associated with numerous physical and mental disorders. One of the known mechanisms in the tinnitus area with unknown reason is oxidative events. Based on the prevalence and economic costs and physical-psychological side effects caused by tinnitus and the importance of finding a suitable solution for its prevention and treatment, the need for further studies becomes more obvious in this context. This review article aimed to review studies on the effectiveness of Ginkgo biloba as a medicinal plant on patients with tinnitus. Evidence Acquisitions: Google Scholar, Directory of Open Access Journals (DOAJ), PubMed, LISTA (EBSCO) and Web of Science have been searched. Results: There are many studies on the therapeutic effect of Ginkgo biloba on patients with tinnitus. Most findings are in contrast with each other so that some of studies reported that Ginkgo biloba is effective in the treatment of tinnitus and other studies referred to it as ineffective herbal medicine. Generally, according to the previous studies and the present study, it can mention that the Ginkgo biloba may somewhat improve tinnitus. Conclusion: Since tinnitus is multifactorial, it is recommended to evaluate patients individually based on the cause of tinnitus, treatment formulas, and different doses of Ginkgo biloba at the more extensive level in future studies.

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“…Han and colleagues30 report a cross-over trial of clonazepam and ginko biloba for the treatment of tinnitus (see page ) . In this methodically and analytically strong report, the authors used comprehensive psychophysical techniques to objectively assess the severity of tinnitus and used such quantitative outcome measures to prove the efficacy of clonazepam for the treatment of tinnitus.…”

Section: Increased Spontaneous Activity and Pharmacotherapy Of Tinnitmentioning

confidence: 99%