Clonidine

Yk, Seedat; Vawda, E I; Mitha, S; Ramasar, R

doi:10.1016/s0140-6736(69)90283-9

Cited by 6 publications

(2 citation statements)

References 1 publication

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“…Because clonidine was administered systemically in this study, we can not also exclude the possibility of peripherally mediated actions (e.g., antihypertension; Seedat et al, 1969). In addition, we can not exclude the possibility of differential effects in other conditions as suggested by the time-and dose-dependent results reported elsewhere in DSP4-treated mice (Archer and Fredriksson, 2000).…”

Section: Discussionmentioning

confidence: 91%

Effects of Spinal α₂-Adrenoceptor and I₁-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice

Lapointe

Ung²,

Rouleau³

et al. 2008

J Pharmacol Exp Ther

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A partial recovery of locomotor functions has been shown in spinal cord-transected (Tx) cats after regular treadmill training and repeated administration of clonidine, an ␣ 2 -adrenoreceptor agonist. However, clonidine has generally failed to show prolocomotor effects in other models (e.g., rat or mudpuppy in vitro-isolated spinal cord preparations). The reasons for this discrepancy remain unclear, but they may suggest conditionor species-specific effects induced by clonidine. This study is aimed at examining both the acute (at 6 or 41 days post-Tx) and chronic effects of repeated (once a week for one month) clonidine administration (0.25-5.0 mg/kg i.p.) on hindlimb movement generation in Tx mice (thoracic segment9/10). Locomotor-like (LM) and nonlocomotor movements (NLM) were assessed both in open-field and treadmill conditions. The results show that clonidine consistently failed, in both conditions, to induce LM and NLM at all time points even though control experiments revealed hindlimb movements steadily induced by 8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT), a serotonin receptor agonist. In turn, clonidine acutely suppressed (I 1 -imidazoline receptor-mediated) the frequency of spontaneously occurring LM and NLM but apparently increased spinal excitability over time, because the frequency of spontaneous LM and NLM was significantly greater in clonidine-treated (before an injection) than vehicle-treated animals after repeated administration for a few weeks. The results clearly show that clonidine can not acutely induce hindlimb movements in untrained and otherwise nonstimulated (e.g., no tail or perineal pinching) Tx mice, although repeated administration may progressively facilitate the expression of spontaneous hindlimb movements.

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Section: Discussionmentioning

confidence: 91%

Effects of Spinal α₂-Adrenoceptor and I₁-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice

Lapointe

Ung²,

Rouleau³

et al. 2008

J Pharmacol Exp Ther

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“…Several groups have, however, transferred patients previously treated with methyldopa to clonidine treatment. In a preliminary report Seedat et al (1969) described 30 patients treated in this way, stating that "effective" control of blood pressure was achieved with both drugs. Nevertheless, clonidine caused side effects in 23 and methyldopa in only 11 of the 30 patients.…”

Section: Discussion Present Data Methyldopa Adminis-mentioning

confidence: 99%

Hypotensive Action and Side Effects of Clonidine-Chlorthalidone and Methyldopa-Chlorthalidone in Treatment of Hypertension

Améry¹,

Verstraete²,

Bossaert³

et al. 1970

BMJ

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Clinical Features of Adrenergic Agonists and Antagonists

Prichard¹,

Owens²,

Tuckman³

1981

Handbook of Experimental Pharmacology

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Clonidine

Cited by 6 publications

References 1 publication

Effects of Spinal α₂-Adrenoceptor and I₁-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice

Effects of Spinal α₂-Adrenoceptor and I₁-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice

Hypotensive Action and Side Effects of Clonidine-Chlorthalidone and Methyldopa-Chlorthalidone in Treatment of Hypertension

Clinical Features of Adrenergic Agonists and Antagonists

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Clonidine

Cited by 6 publications

References 1 publication

Effects of Spinal α2-Adrenoceptor and I1-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice

Effects of Spinal α2-Adrenoceptor and I1-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice

Hypotensive Action and Side Effects of Clonidine-Chlorthalidone and Methyldopa-Chlorthalidone in Treatment of Hypertension

Clinical Features of Adrenergic Agonists and Antagonists

Contact Info

Product

Resources

About

Effects of Spinal α₂-Adrenoceptor and I₁-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice

Effects of Spinal α₂-Adrenoceptor and I₁-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice