Clonidine and propranolol paradoxical hypertension

Warren, Sanford E.; Ebert, Edward; Swerdlin, A H; Steinberg, Steven M.; Stone, Richard A.

doi:10.1001/archinte.139.2.253

Cited by 19 publications

(1 citation statement)

References 2 publications

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“…However, when taken in combination, they have the opposite effect. They dispose towards the raising of blood pressure (see [5,6]). This is known as an antipathetic composition ([3], p. 91).…”

Section: Introductionmentioning

confidence: 99%

Causation in evidence‐based medicine: in reply to Strand and Parkkinen

Kerry

Eriksen

Lie

et al. 2014

Evaluation Clinical Practice

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Strand and Parkkinen criticise our dispositional account of causation in medicine for failing to provide a proper epistemology of causal knowledge. In particular, they claim that we do not explain how causal inferences should be drawn. In response, we point out that dispositionalism does indeed have an account of the epistemology of causation, including counterfactual dependence, intervention, prediction and clinical decision. Furthermore, we argue that this is an epistemology that fits better with the known fallibility of even our bestinformed predictions. Predictions are made on the basis that causes dispose or tend towards their effects, rather than guarantee them. The ontology of causation remains a valuable study for, among other reasons, it tells us that powers do not always combine additively.This counts against the mono-causality that is tested by RCTs.

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Section: Introductionmentioning

confidence: 99%

Causation in evidence‐based medicine: in reply to Strand and Parkkinen

Kerry

Eriksen

Lie

et al. 2014

Evaluation Clinical Practice

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High blood pressure. A side effect of drugs, poisons, and food

Grossman

Messerli²

1995

Archives of Internal Medicine

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A variety of therapeutic agents or chemical substances can induce either a transient or a sustained increase in blood pressure. These agents increase arterial pressure by either causing sodium retention and extracellular volume expansion or directly or indirectly activating the sympathetic nervous system. Some agents act directly on arteriolar smooth muscle. For certain agents, the mechanism of pressure elevation is mixed or unknown. Paradoxically, some agents that are used to lower arterial pressure may acutely increase arterial pressure. Also, a rebound increase in pressure may be encountered after discontinuation of certain antihypertensive agents. In general, these chemically induced increases in arterial pressure are small and transient; however, severe hypertension involving encephalopathy, stroke, and irreversible renal failure has been reported. Careful evaluation of a patient's drug regimen may identify chemically induced hypertension and prevent the need for evaluation and therapy. This study reviews the therapeutic agents or chemical substances that elevate blood pressure and their mechanisms of action.

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Rebound Hypertension Following Abrupt Cessation of Clonidine and Metoprolol

Mehta¹

1987

Arch Intern Med

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Clonidine and propranolol paradoxical hypertension

Cited by 19 publications

References 2 publications

Causation in evidence‐based medicine: in reply to Strand and Parkkinen

Causation in evidence‐based medicine: in reply to Strand and Parkkinen

High blood pressure. A side effect of drugs, poisons, and food

Rebound Hypertension Following Abrupt Cessation of Clonidine and Metoprolol

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