“…Meta-analyses (table 1) indicate that various pharmacological treatments improve SC: nicotine replacement therapy, substitutes of nicotine [64,65,66,67,68,69], bupropion and nortriptyline (antidepressants) [67,70,71,72,73,74], and varenicline, cytisine and mecamylamine (agonists of the nicotine acetylcholine receptors) [67,75,76,77,78]. Naltrexone, an opioid antagonist, has no significant impact on SC [79].…”