Clonidine may have a beneficial effect on refractory nocturnal enuresis

Ohtomo, Yoshiyuki

doi:10.1111/ped.13269

Cited by 11 publications

(9 citation statements)

References 21 publications

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“…Treatment of MPH or AMPH will increase compliance and motivation with better outcomes of incontinence therapy 4,20 . There is also evidence of an antienuretic effect of ADHD medication, especially atomoxetine and clonidine/guanfacine which could lead to synergic effects in the treatment of NE in children with ADHD 55–57 …”

Section: Resultsmentioning

confidence: 99%

Neurodevelopmental disorders and incontinence in children and adolescents: Attention‐deficit/hyperactivity disorder, autism spectrum disorder, and intellectual disability—A consensus document of the International Children's Continence Society

Gontard

Hussong

Yang

et al. 2021

Neurourology and Urodynamics

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Aims: Neurodevelopmental disorders (NDs) are incapacitating disorders, which begin early in life, are mainly caused by genetic and neurobiological factors, and show a tendency to persist. They are associated with higher rates of incontinence in children and adolescents, including nocturnal enuresis, daytime urinary incontinence, fecal incontinence, and constipation. Without diagnosis and treatment, they will interfere with incontinence treatment leading to less favorable outcomes. The aim of this International Children's Continence Society (ICCS) document is to provide an overview of the three most important NDs, that is, attention-deficit/hyperactivity disorder, autism spectrum disorder (ASD), and intellectual disability (ID).Methods: This consensus paper was commissioned by the ICCS. A selective, nonsystematic review was performed. Guidelines, reviews, and selected studies were included. The recommendations are consensus-based.

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Section: Resultsmentioning

confidence: 99%

Neurodevelopmental disorders and incontinence in children and adolescents: Attention‐deficit/hyperactivity disorder, autism spectrum disorder, and intellectual disability—A consensus document of the International Children's Continence Society

Gontard

Hussong

Yang

et al. 2021

Neurourology and Urodynamics

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“…In 30–50% of children with sleep apnoea and enuresis, treatment for the sleep apnoea alone results in a resolution of their enuresis . In children who have sleep problems, the addition of melatonin or clonidine to standard treatment for enuresis resulted in improved treatment outcomes but not if melatonin was used alone (without the addition of other enuresis treatments), suggesting that improving the sleep in these children may result in better treatment response to standard enuresis therapy.…”

Section: Why Standard Treatments For Enuresis Failsmentioning

confidence: 99%

Tips for managing treatment‐resistant enuresis

Caldwell

2018

J Paediatrics Child Health

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Enuresis (bedwetting) is common in school‐aged children and can impact health, psychosocial well‐being and quality of life. Although effective treatment is available, treatment resistance is encountered in about 50%. This paper discusses the management of treatment‐resistant enuresis from a multidisciplinary perspective. Causes of treatment resistance include lower urinary tract problems, constipation, incorrect alarm training techniques, sleep disorders including sleep apnoea and psychological comorbidities. Practical suggestions to address treatment resistance are offered utilising expertise from clinicians from different disciplines.

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“…4) Tonsillectomy is also a treatment option (23,24). In addition, many researchers have investigated the use of combination therapies (25-28), the underlying mechanisms of the disease (29)(30)(31), and the prognosis and adverse reactions associated with these therapies to improve their efficacy and safety (30,32,33). However, although there has been some theoretical basis in the pathogenesis, there is no consensus.…”

Section: Introductionmentioning

confidence: 99%

Bibliometric and visual analysis of nocturnal enuresis from 1982 to 2022

Yang

Tian

et al. 2022

Front. Pediatr.

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Nocturnal enuresis is a common disorder among children that seriously affects physical and mental health and has become a social problem. Bibliometric analysis is a valid way to examine existing research results, current research hotspots and research frontiers. Current studies on nocturnal enuresis are numerous and complex, but a bibliometric analysis of the existing research on nocturnal enuresis has yet to be published. To better identify the research trends and frontiers in nocturnal enuresis, it is necessary to conduct a comprehensive review and analysis. We used bibliometric and visualization methods to analyze the 1,111 papers published between 1982 and 2022 from the Web of Science core collection. Basic information about the country, institution, and authors was analyzed, which led to a basic understanding of nocturnal enuresis. The United States is the most prolific country, Ghent University is the most influential institution, and Rittig Soren is the most prominent scholar. The frequency of keywords, clustering, and the cited literature were analyzed to understand the hotspots and frontiers of research, and a brief review of the highly cited literature was conducted. The current research hotspots are the treatment modalities for nocturnal enuresis, epidemiological investigations, and the exploration of pathogenesis. Clinical research, adenoidectomy, aquaporin 2, and response inhibition are potential research hotspots. The standardization of terminology in nocturnal enuresis and the pathologies of polyuria and sleep disorder are at the forefront of research. In summary, the results of our bibliometric analysis reveal views on the current situation and the trend of nocturnal enuresis research for the first time. This study may provide guidance for promoting research on nocturnal enuresis.

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Clonidine may have a beneficial effect on refractory nocturnal enuresis

Abstract: Clonidine could be an aid for refractory enuresis, although further randomized controlled trials are needed.

Cited by 11 publications

References 21 publications

Neurodevelopmental disorders and incontinence in children and adolescents: Attention‐deficit/hyperactivity disorder, autism spectrum disorder, and intellectual disability—A consensus document of the International Children's Continence Society

Neurodevelopmental disorders and incontinence in children and adolescents: Attention‐deficit/hyperactivity disorder, autism spectrum disorder, and intellectual disability—A consensus document of the International Children's Continence Society

Tips for managing treatment‐resistant enuresis

Bibliometric and visual analysis of nocturnal enuresis from 1982 to 2022

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