Cloning and characterisation of rosmarinic acid synthase from Melissa officinalis L.

Weitzel, Corinna; Petersen, Maike

doi:10.1016/j.phytochem.2011.01.039

Cited by 65 publications

(44 citation statements)

References 38 publications

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“…The variation can be found even in corresponding genes in closely related species: rosmarinic acid synthase (RAS) from Coleus blumei (syn. Table 3 Phytochem Rev while the RAS gene from Melissa officinalis is intronfree (Weitzel and Petersen 2011).…”

Section: Hydroxycinnamoyltransferases Of the Bahd Superfamilymentioning

confidence: 99%

Hydroxycinnamoyltransferases in plant metabolism

Petersen

2015

Phytochem Rev

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Hydroxycinnamoyltransferases are enzymes transferring hydroxycinnamoyl units like cinnamoyl, 4-coumaroyl, caffeoyl, feruloyl and sinapoyl moieties from an activating residue such as coenzyme A or glucose or activated as hydroxycinnamoyl ester (e.g. chlorogenate) to an acceptor molecule, most commonly to an OH or NH 2 group as ester or amide. The hydroxycinnamoyl groups play either a ''decorating'' role or are building blocks of more complex structures. Proteins catalysing hydroxycinnamoyl transfer have been known for many decades and are nowadays investigated on molecular and structural levels. At least four different protein families give rise to enzymes with hydroxycinnamoyltransferase activity: serine carboxypeptidase-like proteins, tyramine hydroxycinnamoyltransferase-like enzymes, BAHD acyltransferases and GDSL-lipase/esterase-like enzymes. Interestingly, the same or very similar products can be formed by enzymes from different enzyme classes and using differently activated hydroxycinnamoyl units. This review will summarise the current literature data on the features of hydroxycinnamoyltransferases from the four different enzyme groups. Keywords BAHD acyltransferase Á GDSL lipase/esterase-like acyltransferase Á Phenolic metabolism Á Serine carboxypeptidase-like acyltransferase Á THT-like hydroxycinnamoyltransferase Abbreviations HCT Hydroxycinnamoyltransferase HQT Hydroxycinnamoyl-CoA:quinate hydroxycinnamoyltransferase HST Hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyltransferase SCPL Serine caryboxypeptidase-like THT Tyramine hydroxycinnamoyltransferase Hydroxycinnamic acid moieties in plant secondary products (Hydroxy)cinnamoyl units such as cinnamic, 4-coumaric, caffeic, ferulic and sinapic acids and their reduced derivatives (aldehydes, alcohols) are ubiquitous building blocks in plant secondary metabolites. In many cases, the (hydroxy)cinnamoyl unit is an essential structural feature, in other cases it is a ''decorating'' part of the molecule (Petersen et al. 2010 and literature cited therein). Substituted hydroxycinnamyl alcohols (4-coumaryl, coniferyl = guajacyl, sinapyl = syringyl units) are the basis for the M. Petersen (&)

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Section: Hydroxycinnamoyltransferases Of the Bahd Superfamilymentioning

confidence: 99%

Hydroxycinnamoyltransferases in plant metabolism

Petersen

2015

Phytochem Rev

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“…Lemon balm has been used traditionally for centuries as sedative, relaxant, stomachic, antispasmodic, carminative, diaphoretic, febrifuge, antiviral, antiseptic and nerve tonic in folk medicine. Traditional uses include healing wounds, relieving palpitations and relaxing the hearth, and treating toothache [5][6][7][8][9][10]. Preparations from leaves are used to treat feverish colds and headaches, to relieve menstrual cramps, and to calm nervous stomachs [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Magnetic Field Treatments on Seed Germination of Melissa officinalis L.

Ulgen

Yıldırım

Türker

2017

International Journal of Secondary Metabolite

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Melissa officinalis L., commonly known as lemon balm, is a perennial herb belonging to Lamiaceae family. It has therapeutic properties, such as sedative, carminative, antispasmodic, anti-viral, wound healing, digestive, diuretic, diaphoretic, anti-septic and anti-thyroid. Lemon balm has been used for the treatment of headache, indigestion, colic, nervousness, cardiac problems, depression, rheumatism, indigestion, hypersensitivities, anxiety and depression traditionally. Beneficial effects of lemon balm are ascribed to the phenolic compounds such as rosmarinic acid, tannins and flavonoids. Studies showed that magnetic field applications in agriculture can be used to improve the quality and quantity of the product. Positive effects of the stationary magnetic field on the plant seed germination have been recorded with some plant species. In this study, effects of magnetic field on M. officinalis seeds were investigated. Seeds were sterilized in 0.1 % HgCl2 for 10 min and 70 % Ethanol for 1-2 min. After surface sterilization of the seeds, they were placed in petri dishes containing Murashige and Skoog's medium with sucrose and agar. Neodymium block magnets (100 X 50 X 5 mm) were used to create magnetic fields (50 mT and 100 mT). Ten seeds were placed in each petri plates and 10 petri plates were used for each treatment. Petri dishes containing surface sterilized seeds were placed in 3 different conditions [without magnetic field application (control) and magnetic field applications (low-50 mT and high-100 mT)] and the germination (radicle protrusion) was assessed. Seeds were exposed to magnetic fields for 1, 3, 6, 12, 24, 48, 72, 144 and 240 hours. The number of germinated seeds was recorded for 20 days. Best seed germination was obtained with 100 mT magnetic field application for 1 hour (52 %). Seed germination rate was rather low (28 %) without magnetic field application (control). In consistent with 100 mT magnetic field application, 1 hour exposure to 50 mT magnetic field gave better germination rate (36 %) than control. The lowest seed germination was observed with 240 hours exposure to both magnetic fields (27 % for 100 mT and 16 % for 50 mT). Magnetic field applications also decreased the seed germination time. Although seed germination was observed in 11. day with control, it was obtained in 7. day with both magnetic field applications. Magnetic field application enhanced the percentage of germinated seed and shortened the period of seed germination in M. officinalis.

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“…The herb exhibited a wide scope of pharmaceutical properties such as sedative, carminative, antispasmodic, antibacterial, antiviral, antifungal, anti-inflammatory and antioxidative. Furthermore, M. officinalis is used to treat Graves', Alzheimer's and thyroid diseases (Kim et al 2010;Weitzel & Petersen 2011).…”

Section: Introductionmentioning

confidence: 99%

Physiological and biochemical responses ofMelissa officinalisL. to nickel stress and the protective role of salicylic acid

Maivan

Radjabian

Abrishamchi

et al. 2016

Archives of Agronomy and Soil Science

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The present study investigated the mediatory effects of salicylic acid (SA) in alleviating nickel (Ni) toxicity in Melissa officinalis L. One-month old plants were exposed to different levels of Ni and SA concentrations in sand culture under greenhouse conditions. Excess Ni significantly inhibited the growth indices, and dramatically increased accumulation of Ni in the leaves and roots. Exogenously SA applications (1.0 mM) led to a substantial improvement in the shoot and root fresh and dry weights. Foliar application of SA mitigated the deleterious effects of Ni and decreased its transport to the shoots. The results showed a significant loss in chlorophylls and carotenoids contents only at 500µM of Ni. The impact of SA was not significant in terms of chlorophylls contents, while carotenoids contents of the Ni-stressed Downloaded by [University of Bath] at 08:50 29 June 2016 plants were significantly affected by SA. Exposure to Ni did not modify proline accumulation. Hydrogen peroxide accumulation was observed under Ni stress, while lipid peroxidation significantly decreased at the same conditions. Application of SA caused a significant decrease in electrolyte leakage of Ni-stressed plants. Due to the high potential for Ni accumulation in the roots and TF values lower than 1, M. officinalis could be introduced as an excluder medicinal plant.

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Cloning and characterisation of rosmarinic acid synthase from Melissa officinalis L.

Cited by 65 publications

References 38 publications

Hydroxycinnamoyltransferases in plant metabolism

Hydroxycinnamoyltransferases in plant metabolism

Effect of Magnetic Field Treatments on Seed Germination of Melissa officinalis L.

Physiological and biochemical responses ofMelissa officinalisL. to nickel stress and the protective role of salicylic acid

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