Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family

The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity

“…61,66 The ectopic expression of IL-17C in vivo by different methodologies also causes inflammatory responses in the lungs, joints and skin. 19,61,67 Mechanistically, IL-17C binds to the IL-17RE-IL-17RA receptor complex to induce downstream signaling pathway activation.…”

The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease

“…First cloned in 1993 from a murine cDNA library and known originally as CTLA-8 [23,24], IL-17A is a member of a family of IL-17 cytokines (IL-17A-F [25][26][27][28][29]) which are structurally homologous to each other and to a gene in the herpesvirus saimiri [23,30]. It was described initially as a product of activated and memory CD4 + T cells [23,30,30,31] but it is now known that the production of IL-17A is more ubiquitous and has been demonstrated in gd T cells [32], CD8 + memory T cells [31,33], eosinophils [34], neutrophils [31] and monocytes [35].…”

A Heterodimeric Cytokine, Consisting of IL-17A and IL-17F, Promotes Migration and Capillary-Like Tube Formation of Human Vascular Endothelial Cells

“…The other IL-17 cytokine family members, IL-17B, IL-17C, and IL-17D, are mainly produced by a non-T cell source. Members of this cytokine family are secreted as disulfide-linked homodimers, with the exception of IL-17B, which is secreted as a non-covalent homodimer (Li et al 2000). On the other hand, the IL-17 receptor family contains five receptor subunits, IL-17 receptor A (IL-17RA), IL-17RB, IL-17RC, IL-17RD and IL-17RE.…”