Cloning and expression analysis of Fgf5, 6 and 7 during early chick development

Kumar, M. Suresh; Chapman, Steve

doi:10.1016/j.gep.2012.05.002

Cited by 13 publications

(7 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intriguingly, both 3′Hox and Fgf7 genes are expressed in the proximal region of the tetrapod limb (Fig. 1G) (22,27). Furthermore, Fgf7 can induce Fgf8, the AER marker in chicken (28).…”

Section: Discussionmentioning

confidence: 93%

Molecular mechanisms underlying the exceptional adaptations of batoid fins

Nakamura

Klomp

Pieretti

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Extreme novelties in the shape and size of paired fins are exemplified by extinct and extant cartilaginous and bony fishes. Pectoral fins of skates and rays, such as the little skate (Batoid, Leucoraja erinacea), show a strikingly unique morphology where the pectoral fin extends anteriorly to ultimately fuse with the head. This results in a morphology that essentially surrounds the body and is associated with the evolution of novel swimming mechanisms in the group. In an approach that extends from RNA sequencing to in situ hybridization to functional assays, we show that anterior and posterior portions of the pectoral fin have different genetic underpinnings: canonical genes of appendage development control posterior fin development via an apical ectodermal ridge (AER), whereas an alternative Homeobox (Hox)-Fibroblast growth factor (Fgf )-Wingless type MMTV integration site family (Wnt) genetic module in the anterior region creates an AER-like structure that drives anterior fin expansion. Finally, we show that GLI family zinc finger 3 (Gli3), which is an anterior repressor of tetrapod digits, is expressed in the posterior half of the pectoral fin of skate, shark, and zebrafish but in the anterior side of the pelvic fin. Taken together, these data point to both highly derived and deeply ancestral patterns of gene expression in skate pectoral fins, shedding light on the molecular mechanisms behind the evolution of novel fin morphologies.skate | fin | evolution | development | AER

show abstract

“…Intriguingly, both 3′Hox and Fgf7 genes are expressed in the proximal region of the tetrapod limb (Fig. 1G) (22,27). Furthermore, Fgf7 can induce Fgf8, the AER marker in chicken (28).…”

Section: Discussionmentioning

confidence: 93%

Molecular mechanisms underlying the exceptional adaptations of batoid fins

Nakamura

Klomp

Pieretti

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Notably, FGF6 is located near the center of the QTL interval (34 kb downstream of the LG1 peak marker). FGF6 is expressed in craniofacial structures during chicken embryogenesis (Kumar and Chapman 2012), and Fgf6 -/- mutant mice have shorter snouts than their wildtype littermates (Floss et al . 1997), demonstrating a role for this gene in outgrowth of vertebrate facial structures.…”

Section: Resultsmentioning

confidence: 99%

Complex genetic architecture of three-dimensional craniofacial shape variation in domestic pigeons

Boer

Maclary

Shapiro

2021

Preprint

View full text Add to dashboard Cite

Deciphering the genetic basis of vertebrate craniofacial variation is a longstanding biological problem with broad implications in evolution, development, and human pathology. One of the most stunning examples of craniofacial diversification is the adaptive radiation of birds, in which the beak serves essential roles in virtually every aspect of their life histories. The domestic pigeon (Columba livia) provides an exceptional opportunity to study the genetic underpinnings of craniofacial variation because of its unique balance of experimental accessibility and extraordinary phenotypic diversity within a single species. We used traditional and geometric morphometrics to quantify craniofacial variation in an F2 laboratory cross derived from the straight-beaked Pomeranian Pouter and curved-beak Scandaroon pigeon breeds. Using a combination of genome-wide quantitative trait locus scans and multi-locus modeling, we identified a set of genetic loci associated with complex shape variation in the craniofacial skeleton, including beak curvature, braincase shape, and mandible shape. Some of these loci control coordinated changes between different structures, while others explain variation in the size and shape of specific skull and jaw regions. We find that in domestic pigeons, a complex blend of both independent and coupled genetic effects underlie three-dimensional craniofacial morphology.

show abstract

“…In zebrafish and frog embryos, foxq1 is expressed in the pharyngeal region ( Choi et al, 2006 ; Planchart and Mattingly, 2010 ). In chick embryos, fgf7 is first expressed in the pharyngeal endoderm and head mesoderm ( Kumar and Chapman, 2012 ). However, foxq1 has been shown to be a downstream target of AhR in other tissues ( Faust et al, 2013 ), and crude oil exposures strongly induced fgf7 expression in the livers of juvenile polar cod ( Andersen et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish

Sørhus

Incardona

Furmanek

et al. 2017

eLife

View full text Add to dashboard Cite

Crude oil spills are a worldwide ocean conservation threat. Fish are particularly vulnerable to the oiling of spawning habitats, and crude oil causes severe abnormalities in embryos and larvae. However, the underlying mechanisms for these developmental defects are not well understood. Here, we explore the transcriptional basis for four discrete crude oil injury phenotypes in the early life stages of the commercially important Atlantic haddock (Melanogrammus aeglefinus). These include defects in (1) cardiac form and function, (2) craniofacial development, (3) ionoregulation and fluid balance, and (4) cholesterol synthesis and homeostasis. Our findings suggest a key role for intracellular calcium cycling and excitation-transcription coupling in the dysregulation of heart and jaw morphogenesis. Moreover, the disruption of ionoregulatory pathways sheds new light on buoyancy control in marine fish embryos. Overall, our chemicalgenetic approach identifies initiating events for distinct adverse outcome pathways and novel roles for individual genes in fundamental developmental processes.

show abstract

Cloning and expression analysis of Fgf5, 6 and 7 during early chick development

Cited by 13 publications

References 46 publications

Molecular mechanisms underlying the exceptional adaptations of batoid fins

Molecular mechanisms underlying the exceptional adaptations of batoid fins

Complex genetic architecture of three-dimensional craniofacial shape variation in domestic pigeons

Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish

Contact Info

Product

Resources

About