Cloning and functional characterization of dog transient receptor potential vanilloid receptor-1 (TRPV1)

Phelps, P. Tara; Anthes, John C.; Correll, Craig C.

doi:10.1016/j.ejphar.2005.02.045

Cited by 32 publications

(27 citation statements)

References 23 publications

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“…Caterina and co-workers cloned TRPV1 from a rat sensory neuron cDNA library and showed that the receptor is expressed in both the dorsal root (DRG) and trigeminal ganglia (TG) [24]. TRPV1 has also been cloned from humans [25], guinea pigs [26], rabbits [27], mouse mice [28] and dogs [29].…”

Section: Trpvs: a Brief Overviewmentioning

confidence: 99%

Is TRPV1 a useful target in respiratory diseases?

Takemura

Quarcoo

Niimi

et al. 2008

Pulmonary Pharmacology & Therapeutics

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This review focuses on the transient receptor potential vanilloid 1 (TRPV1). TRPV1 is a non-selective cation channel predominantly expressed in the cell membranes of sensory afferent fibers, which are activated multi-modally. In the mammalian respiratory system, immunohistochemical and electrophysiological studies have revealed heterogeneous localizations of TRPV1 channels in the airways and their presence in pleural afferents. TRPV1 channels in afferents are not only involved with sensory inputs, but also release several neuropeptides upon stimulation. These processes trigger pathophysiological effects (e.g. reflex bronchoconstriction, hypersecretion, cough, etc.) that cause various symptoms of airway diseases.Recent studies have identified several endogenous and exogenous substances that can activate TRPV1 in the lung. Because of its key role in initiating inflammatory processes, TRPV1 receptor antagonists have been proposed as therapeutic candidates. Therefore, a critical update of recent therapeutic results is also given in this review.

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Section: Trpvs: a Brief Overviewmentioning

confidence: 99%

Is TRPV1 a useful target in respiratory diseases?

Takemura

Quarcoo

Niimi

et al. 2008

Pulmonary Pharmacology & Therapeutics

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“…The first time that TRPV1 was identified in canine tissues was during the study of Phelps et al [15] . Their project was addressed to clone dog TRPV1 cDNA from dog nodose ganglia, and to characterize this orthologue in transfected HEK293 OFF cells.…”

Section: Dogmentioning

confidence: 99%

“…Especially in mammalians and birds, TRPV1 orthologues have been cloned, and their channel properties have been characterized in considerable details [10,11,12,13,14,15] .…”

Section: Introductionmentioning

confidence: 99%

Transient Receptor Potential Vanilloid 1 in animal tissues: An overview to highlight similarities and differences with human species

Vercelli

Barbero

2015

Receptor Clin Invest

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The purpose of this review is to give an overview of the identification and the characterization of Transient Receptor Potential Vanilloid 1 (TRPV1) in animal tissues. TRPV1 is a receptor belonging to the superfamily of Transient Receptor potential (TRP) and it was first identified in dorsal root ganglion in 1997. After, the scientific interest on this receptor increased, and nowadays it is possible to read a huge bibliography dealing with this receptor that is considered ubiquitarian. Actually, it was identified in the majority of animal and human tissues in physiological and pathological conditions. The involvement of TRPV1 receptor is considered as a key to understand aetiopathogenic mechanisms and to try to find a therapeutic treatment. In spite of the deep knowledge on TRPV1 molecular structure, more studies are required to better understand the cascade following its activation. For all the previous mentioned reasons, TRPV1 was investigated in species of interest of Veterinary Medicine and some of them are important animal models for human medicine, especially for oncology and analgesic therapeutic strategies.

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“…The first identification of TRPV1 in dog Tissues (dTRPV1) was done by Phelps et al (2005): The receptor displayed similarities to human's orthologue suggesting that dog could be a good model for inflammatory diseases and nociception. Nowadays, canine experimental model concerning TRPV1 is commonly used in oncologic researches (Pihno et al, 2012;Vercelli et al, 2013).…”

Section: Dogsmentioning

confidence: 99%

“…Moreover, different investigations cloned and characterised TRPV1 orthologues in the majority of mammalian and birds tissues (Hayes et al, 2000;Jordt and Julius, 2002;Savidge et al, 2002;Correll et al, 2004;Gavva et al, 2004;Phelps et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Transient Receptor Potential Vanilloid 1 Involvement in Animal Pain Perception

Vercelli¹,

Barbero²

2015

American Journal of Animal and Veterinary Sciences

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In last decades, Transient Receptor Potential Vanilloid 1 (TRPV1) has been the target of a large number of scientific investigations. It has been identified as a polymodal transducer molecule on a sub-set of primary sensory neurons which responds to various endogenous and exogenous stimuli including noxious heat (more than 42°C), protons and vanilloids such as capsaicin, the hot ingredient of chilli peppers. In mammals, TRPV1 displays a wide tissue and cellular expression including both the peripheral and central nervous system, with broad distribution and functions, in physiological and pathological conditions. Its primary localisation in sensory neurons reveals its key nodal point in pain transmission pathways. Nowadays, it is clear that TRPV1 is involved in inflammation, pain perception and thermoregulation in the majority of animals, including humans. Recently, a lot of studies tried to investigate some analgesic treatments applied on TRPV1. The aim of this review is to give to the readers a short overview of the TRPV1 involvement in pain perception and possible therapeutic applications, highlighting this topic in species of interest in veterinary medicine.

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Cloning and functional characterization of dog transient receptor potential vanilloid receptor-1 (TRPV1)

Cited by 32 publications

References 23 publications

Is TRPV1 a useful target in respiratory diseases?

Is TRPV1 a useful target in respiratory diseases?

Transient Receptor Potential Vanilloid 1 in animal tissues: An overview to highlight similarities and differences with human species

Transient Receptor Potential Vanilloid 1 Involvement in Animal Pain Perception

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