Cloning and molecular characterization of the orphan carrier protein Slc10a4: Expression in cholinergic neurons of the rat central nervous system

Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions

“…Several classes of SLC transporters have been shown to mediate DHEAS uptake, including OATP1A2, 1B1, 1B3, and 2B1 [10,11], OAT2, 3, and 4 [20][21][22], and Na + -dependent taurocholate cotransporting polypeptide (NTCP) [23]. Hence, we conducted gene expression profiling of human prostate cancer LNCaP cells cultured under androgen-depleted conditions (Table 2A and Table 3).…”

The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants

“…The gene Slc10A4 encodes a carrier protein that is expressed in cholinergic and monoaminergic neurons, where it colocalizes with markers for pre-synaptic terminals such as VAChT (Burger et al, 2011;Geyer et al, 2008). The Slc10a4 protein (henceforth referred to as Slc10a4) is highly expressed in the cholinergic system, but the biological significance of Slc10a4 regarding cholinergic function has not been investigated.…”

Transporters

“…Kemp G, Young H, Fliegel L (2008). Structure and function of the human Na (Meier et al, 1997) Thyroid hormone (Friesema et al, 1999;Visser et al, 2010) GDCA > GUDCA, GCDA > TCA > CA (Craddock et al, 1998) Estrone-3-sulphate, DHEAS (Geyer et al, 2004), TLCA, PREGS (Geyer et al, 2007) Inhibitors Cyclosporin, propranolol (Kim et al, 1999) --Probes Chenodeoxycholyl-N e -nitrobenzoxadiazollysine (Weinman et al, 1998) [ 3 H]-Taurocholate (Craddock et al, 1998) Stoichiometry 2 Na + : 1 bile acid (Hagenbuch and Meier, 1996;Weinman, 1997) >1 Na + : 1 bile acid (Craddock et al, 1998) Heterologously expressed SLC10A4 (Geyer et al, 2008) or SLC10A7 (Godoy et al, 2007) failed to exhibit significant transport of TCA, PREGS, DHEAS or choline. SLC10A4 has recently been suggested to associate with neuronal vesicles (Burger et al, 2011).…”