1992
DOI: 10.1016/0006-291x(92)91187-u
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Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor

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Cited by 462 publications
(287 citation statements)
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“…Bradykinins act mainly as local hormones by activating specific receptors, known as B1 and B2 receptors, with most of the inflammatory and cardiovascular effects being mediated by the B2 receptor. 22, 23 The human B2 receptor gene has been cloned [24][25][26][27] and mapped to human chromosome region 14q32. 28 The gene is larger than 25 kb and consists of three exons, and cell-surface, G-protein-coupled receptors of the seven-transmembrane-domained superfamily.…”
Section: Discussionmentioning
confidence: 99%
“…Bradykinins act mainly as local hormones by activating specific receptors, known as B1 and B2 receptors, with most of the inflammatory and cardiovascular effects being mediated by the B2 receptor. 22, 23 The human B2 receptor gene has been cloned [24][25][26][27] and mapped to human chromosome region 14q32. 28 The gene is larger than 25 kb and consists of three exons, and cell-surface, G-protein-coupled receptors of the seven-transmembrane-domained superfamily.…”
Section: Discussionmentioning
confidence: 99%
“…In humans, cloned gene sequences of the receptors have confirmed distinct B2 and B1 receptors, each belonging to the seven transmembrane G protein-coupled superfamily (10,11). BK and Lys-BK (kallidin) are equally effective agonists for the B2 receptor; however, the carboxypeptidase metabolite of Lys-BK, Lys-des-Arg-BK, is the only known potent agonist for the human B1 receptor (11,12).…”
mentioning
confidence: 99%
“…In other studies, a change in affinity of B2 kinin receptors (Burch and Axelrod, 1987;Leeb-Lundberg and Mathis, 1990;Liao and Homcy, 1993) or changes in both affinity and receptor number (Mathis and Leeb-Lundberg, 1991) were reported. By contrast, guanosine nucleotides were reported to inhibit [ 3 H]BK binding to the human B2 kinin receptor expressed in COS-7 cells (Hess et al, 1992), while no effect of these nucleotides was observed on BK binding to receptors in guinea pig lung (Trifilieff et al, 1994).…”
Section: Introductionmentioning
confidence: 89%
“…Radioligand binding studies proved the existence of B2 receptors in a variety of tissues and cell lines (Bathon and Proud, 1991). Recently the rat, mouse and human B2 kinin receptors, as well as the human B1 kinin receptor, have been cloned (McEachern et al, 1991;Hess et al, 1992;Menke et al, 1994;Webb et al, 1994) and, based on sequence homology, were grouped into the superfamily of the G protein-coupled receptors (GPCRs). These findings were in agreement with previous reports, that BK, via the B2 receptor, is capable of activating phospholipase A and/or C and of inhibiting adenylate cyclase via signal transduction pathways that utilize guanosine nucleotide regulatory proteins (Liebmann and Reissmann, 1990;Gutowski et al, 1991;Liebmann et al, 1991;McEachern et al, 1991;Tippmer et al, 1994).…”
Section: Introductionmentioning
confidence: 99%