Cloning, expression and comparison of the properties of Scy p 9, a<i>Scylla paramamosain</i>allergen

He, Xinrong; Cheng, Yüan; Yang, Yang; Xie, Jie-Jing; Chu, Ka-Hou; Zhang, Yongxia; Chen, Gui-Xia; Hong, Liu; Cao, Min‐Jie

doi:10.1039/d0fo00004c

Cited by 11 publications

(19 citation statements)

References 41 publications

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“…Arginine kinase is a 41 kDa phosphagen kinase that plays an important role in cellular energy metabolism in invertebrates. Apart from these two major allergens, sarcoplasmic calcium-binding protein, triosephosphate isomerase, pyruvate kinase 2, myosin light chain I and filamin C were minor crab allergens ( 56 , 67 , 68 ). Jasim et al ( 69 ) identified three common crab allergens including tropomyosin, arginine kinase and actin as well as a novel allergen hemocyanin from S. transquebarica that is commonly consumed in Malaysia.…”

Section: Prevalence and Natural History Of Seafood Allergy In Asiamentioning

confidence: 99%

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Seafood Allergy in Asia: Geographical Specificity and Beyond

Wai

Leung

et al. 2021

Front. Allergy

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Asian countries have unique ways of food processing and dietary habits that may explain the observed differences in the prevalence, natural history, epidemiology and sensitization pattern of food allergic diseases when compared to western countries. Per capita consumption of seafood, including fish and shellfish, is well above the global average for many Asian countries because of their coastal geographical location and rich seafood supply. The wide availability and high abundance of seafood in Asian countries have shaped a diverse way of processing and eating this major food group. Such unique features have significant impact on the sensitization profile and allergenicity of Asians to fish and shellfish. For example, fish and shellfish are eaten raw in some countries that may promote sensitization to heat-labile allergens not otherwise seen in other regions. Fermented fish sauce is commonly used as a condiment in some countries which may promote fish sensitization. Shrimp head and shrimp roe are regarded as delicacies in some countries, but their allergen profiles are yet to be characterized. Freshwater fish and shellfish are a common food source in many Asian countries but the allergenicity of many such species remains unknown. In this review, we discuss factors that may contribute to differences in molecular profile and sensitization pattern for fish and shellfish that are observed in Asian populations and revisit the current status of seafood allergy in this part of the world. Acknowledging the similarities and differences of seafood allergy patterns between Asian and western populations can help us refine a better strategy for diagnosing and managing seafood allergy.

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Section: Prevalence and Natural History Of Seafood Allergy In Asiamentioning

confidence: 99%

“…Summary of shellfish and fish allergens. kinase 2, myosin light chain I and filamin C were minor crab allergens(56,67,68). Jasim et al(69) identified three common crab allergens including tropomyosin, arginine kinase and actin as well as a novel allergen hemocyanin from S. transquebarica that is commonly consumed in Malaysia.…”

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confidence: 99%

Seafood Allergy in Asia: Geographical Specificity and Beyond

Wai

Leung

et al. 2021

Front. Allergy

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“…The reason for this is that the hydrophobic tail carried by SDS allows it to enter the interior of the ATM molecule and destroy the hydrophobic effect, exposing the hydrophobic region of the whole protein molecule. 26 He et al 38 reported that the allergenicity of an allergen increased with increasing hydrophobicity. These findings further proved that there was an intermolecular disulfide bond in ATM and indicated that the linear epitope played a major role in the IgE-binding capacity of ATM.…”

Section: Discussionmentioning

confidence: 99%

Identification of linear epitopes and their major role in the immunoglobulin E-binding capacity of tropomyosin from Alectryonella plicatula

Han

et al. 2022

Food Funct.

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“…Other registered shellfish allergens that have been identified at the molecular level include arginine kinase (AK), myosin light chain (MLC), troponin C (TnC), hemocyanin (Hc), triosephosphate isomerase (TIM), fatty acid-binding protein (FABP) and the newly identified 98kDa glycogen phosphorylase (GP) from shrimp [16,17,18 ▪ ]. Filamin C and paramyosin from are on the other hand identified from mud crab ( Scylla paramamosain ) and veined rapa whelk ( Rapana venosa ) respectively [19 ▪ ,20 ▪ ]. By means of inhibition ELISA, Yu et al [21 ▪▪ ] showed that paramyosin played an important role in molluscan and mite-molluscan cross-reactivity, and the relevance of these proteins in other edible shellfish would warrant more characterization.…”

Section: Introductionmentioning

confidence: 99%

Emerging approaches in the diagnosis and therapy in shellfish allergy

Wai

Leung

2022

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewDespite the high prevalence of shellfish allergy, the clinical management of seafood allergy has remained unchanged over decades. Here, we examined the current status in the diagnosis and clinical management of shellfish allergy and highlighted the imminent need for more specific diagnostic methods, as well as effective and safe therapeutic approaches for shellfish allergy.Recent findingsWith the advancement in the molecular identifications and definition of reactive epitopes of shellfish allergens, new diagnostic designs such as component-resolved diagnosis, basophil activation test (BAT) and the emerging IgE-crosslinking-induced luciferase expression are emerging. Furthermore, various allergen-specific immunotherapy strategies (such as shellfish extracts and allergens, hypoallergens, hypoallergen DNA vaccines, mimotopes and peptide-based therapies) are being explored at preclinical stages whereas limited nonallergen specific immunotherapy approaches are under clinical trials.SummaryWith an increasing understanding of the underlying immunological mechanisms and molecular features of shellfish allergy, the future for developing precise diagnostic and therapeutic strategies to better manage shellfish allergy is promising.

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Cloning, expression and comparison of the properties of Scy p 9, aScylla paramamosainallergen

Abstract: This study investigated the properties of Scy p 9 in mud crab (Scylla paramamosain).

Cited by 11 publications

References 41 publications

Seafood Allergy in Asia: Geographical Specificity and Beyond

Seafood Allergy in Asia: Geographical Specificity and Beyond

Identification of linear epitopes and their major role in the immunoglobulin E-binding capacity of tropomyosin from Alectryonella plicatula

Emerging approaches in the diagnosis and therapy in shellfish allergy

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