Cloning genes whose levels of expression are altered by metals: Implications for human health research

Rossman, Toby G.

doi:10.1002/1097-0274(200009)38:3<335::aid-ajim14>3.0.co;2-h

Cited by 17 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased level of 8-oxo-7, 8-dihydro-2-deoxyguanosine and 5-hydroxyl-2-deoxycytidine following chronic treatment with ALA in rats has been attributed for ALA-induced DNA damage [31]. There are recent data suggesting lead-induced alteration in gene expression [32] and it appears to interact with zinc-binding sites on an important DNA-associated protein, human protamine [33]. …”

Section: Lead-induced Oxidative Stressmentioning

confidence: 99%

Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration

Patra

Rautray

Swarup

2011

Veterinary Medicine International

431

259

View full text Add to dashboard Cite

Oxidative stress has been implicated to play a role, at least in part, in pathogenesis of many disease conditions and toxicities in animals. Overproduction of reactive oxygen species and free radicals beyond the cells intrinsic capacity to neutralize following xenobiotics exposure leads to a state of oxidative stress and resultant damages of lipids, protein, and DNA. Lead and cadmium are the common environmental heavy metal pollutants and have widespread distribution. Both natural and anthropogenic sources including mining, smelting, and other industrial processes are responsible for human and animal exposure. These pollutants, many a times, are copollutants leading to concurrent exposure to living beings and resultant synergistic deleterious health effects. Several mechanisms have been explained for the damaging effects on the body system. Of late, oxidative stress has been implicated in the pathogenesis of the lead- and cadmium-induced pathotoxicity. Several ameliorative measures to counteract the oxidative damage to the body system aftermath or during exposure to these toxicants have been assessed with the use of antioxidants. The present review focuses on mechanism of lead- and cadmium-induced oxidate damages and the ameliorative measures to counteract the oxidative damage and pathotoxicity with the use of supplemented antioxidants for their beneficial effects.

show abstract

Section: Lead-induced Oxidative Stressmentioning

confidence: 99%

Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration

Patra

Rautray

Swarup

2011

Veterinary Medicine International

431

259

View full text Add to dashboard Cite

show abstract

“…Leadinduced mutations do not appear to result from direct DNA damage but may occur through indirect mechanisms involving DNA synthesis, DNA repair processes or gene expression [Groot de Restropo et al, 2000;Rossman, 2000;Silbergeld et al, 2000]. Conceivably also, intracellular accumulation of ALA acting as a pro-oxidant might lead to oxidative DNA damage.…”

Section: Mechanisms Of Lead Toxicity and Their Modification By Genetimentioning

confidence: 99%

“…Lead is also reported to cause oxidative damage to DNA, but the evidence for that effect is weak [Fu et al, 1999]. There are recent data that lead may alter gene expression [Rossman, 2000]. One particularly intriguing mechanism for alteration of gene expression is that lead appears to interact with zinc-binding sites on human protamine, an important DNA-associated protein [Quintanilla-Vega et al, 2000].…”

Section: Molecular Mechanisms Of the Carcinogenicity Of Leadmentioning

confidence: 99%

The reproductive toxicity and carcinogenicity of lead: A critical review

2000

View full text Add to dashboard Cite

“…There are recent data that lead may alter gene expression [37] and appears to interact with zinc-binding sites on an important DNA-associated protein, human protamine [38]. In the present study, expression of the gene encoding Cu/Zn SOD in group 3 was observed to decrease in contrast with the control group.…”

Section: Discussionmentioning

confidence: 99%

Effects of Lead on Hepatic Antioxidant Status and Transcription of Superoxide Dismutase Gene in Pigs

Deng

et al. 2008

Biol Trace Elem Res

View full text Add to dashboard Cite

Ninety-six castrated boars (Duroc x Landrace x Yorkshire) were randomly divided into four groups, each of which was replicated three times with eight pigs. The groups received the same basal diet supplemented with 0, 5, 10, and 20 mg/kg lead, respectively. The malondialdehyde and glutathione levels, antioxidant enzymes activities, and zinc/copper superoxide dismutase (Zn/Cu SOD) mRNA content in the liver were determined to evaluate the lead hepatic intoxication caused by the lead. Results showed the increased lipid peroxides level and the reduced glutathione content, along with a concomitant decrease in the activities of superoxide dismutase, catalase, and glutathione peroxidase. Moreover, the level of hepatic Zn/Cu SOD mRNA was also significantly reduced. We suggest potential mechanism for lead intoxication in liver as follows: lead causes parallel decrease in Zn/Cu SOD mRNA and activities of antioxidant enzymes, leading to the declined ability of scavenging free radicals with excessive production of lipid peroxides, which seriously damages the hepatic structure and function.

show abstract

Cloning genes whose levels of expression are altered by metals: Implications for human health research

Cited by 17 publications

References 16 publications

Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration

Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration

The reproductive toxicity and carcinogenicity of lead: A critical review

Effects of Lead on Hepatic Antioxidant Status and Transcription of Superoxide Dismutase Gene in Pigs

Contact Info

Product

Resources

About