Cloning of PCPTP1-Ce encoding protein tyrosine phosphatase from the rat cerebellum and its restricted expression in Purkinje cells

Tyrosine-specific MAPK phosphatases and the control of ERK signaling in PC12 cells

“…1B), in concordance with earlier reports [15,16]. For the rat PTPRR gene two different transcripts, encoding PCPTP1 and PCPTP1-Ce, respectively, have been reported [17,18]. PCPTP1 mRNA is present in PC12 cells [14,17,19] but PCPTP1-Ce transcripts remain undetectable in PC12 RNA, although the amplification product is readily obtained using rat cerebellum RNA (Fig.…”

“…In addition, current in vitro studies might be hampered by the fact that potential ligands for the PCPTP1/PTPBR7 extracellular part, which may critically control the activity of the phosphatase, have not been identified yet. Also in view of the restricted expression pattern of the Ptprr gene [17,24,30] and its conserved potency to generate multiple protein isoforms through the use of different promoters, alternative splicing and multiple start codons [18,20,30] it may well be that the tyrosine phosphatase PTPRR family members will prove physiological regulators of MAPK signaling in other cell systems and following different stimuli than the ones tested here. Given the lack of endogenous PTPRR expression in many neuronal cell lines, studies in PTPRR deficient mice are eagerly awaited to address their functional significance in MAPK signaling in vivo .…”

Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders

“…STEP 61 is expressed in the hippocampus, neocortex, lateral amygdala, and spinal cord, while both STEP 61 and STEP 46 are found in the striatum, central nucleus of the amygdala, and optic nerve (Boulanger et al, 1995; Bult et al, 1996; Lorber et al, 2004). STEP is not expressed in the cerebellum, where the related PTP-SL is localized (Watanabe et al, 1998) and whether PTP-SL has similar functions to STEP in the cerebellum remains to be determined. STEP isoforms are also differentially expressed during development.…”

PTPRR (protein tyrosine phosphatase, receptor type, R)

“…Isoform-specific expression studies on human samples are limited to RT-PCR analyses (Augustine et al, 2000) which in general point to expression patterns that are quite similar to mouse (Van Den Maagdenberg et al, 1999;Augustine et al, 2000) and rat (Watanabe et al, 1998). Human PTPPBSα is expressed exclusively in brain and the PTPPBSγ/δ-type transcripts are also detectable in various other tissues, most notably uterus and intestine (Augustine et al, 2000).…”