Cloning of the hamster androgen receptor gene

Shiba, Kahori; Hamaguchi, Taizo; Kataoka, Kohsuke; Yamaguchi, Yuki; Handa, Hiroshi; Adachi, Kenji

doi:10.1016/s0923-1811(00)00172-9

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…These glands can metabolize T to DHT in both intact and gonadectomized hamster since the 5a-reductase enzyme is present in this tissue [7]. Hamster flank organs also have androgen receptor [8,9]. On the other hand, T increased the rate of incorporation of different lipid synthesis precursors such as labeled glucose or sodium acetate, mainly in glycerides and fatty acids and increased also the polar lipids synthesis (phospholipids) in flank organs [10][11][12], Fig.…”

Section: Introductionmentioning

confidence: 99%

Molecular interactions of natural and synthetic steroids in female hamsters’ flank organs

Cabeza

Naranjo

Heuze

et al. 2012

Journal of Dermatological Science

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Section: Introductionmentioning

confidence: 99%

Molecular interactions of natural and synthetic steroids in female hamsters’ flank organs

Cabeza

Naranjo

Heuze

et al. 2012

Journal of Dermatological Science

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“…These glands can metabolize T to DHT in both intact and gonadectomized animal since the 5␣-reductase enzyme is present in this tissue [12]. Hamster flank organs also have androgen receptor; Shiba et al had reported the cloning of androgen receptor gene in this tissue [13].…”

Section: Introductionmentioning

confidence: 99%

Steroids with a carbamate function at C-17, a novel class of inhibitors for human and hamster steroid 5α-reductase

Bratoeff¹,

Sainz²,

Cabeza³

et al. 2007

The Journal of Steroid Biochemistry and Molecular Biology

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“…AR activation permits transmission of extracellular signals into the cells to produce intracellular responses through the targeting of response elements and recruitment of cofactors 3 . AR is present in androgen-dependent tissues, such as hamster flank organs 4 . pilosebaceous complexes, occurring as two pigmented spots located in the dorsal skin of male and female hamsters 5 .…”

Section: Introductionmentioning

confidence: 99%

Novel dehydroepiandrosterone benzimidazolyl derivatives as 5α-reductase isozymes inhibitors

Arellano

Bratoeff

Segura

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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5a-R isozymes (types 1 and 2) play an important role in prostate gland development because they are responsible for intraprostatic dihydrotestosterone (DHT) levels when the physiological serum testosterone (T) concentration is low. In this study, we synthesized seven novel dehydroepiandrosterone derivatives with benzimidazol moiety at C-17, and determined their effect on the activity of 5a-reductase types 1 and 2. The derivatives with an aliphatic ester at C-3 of the dehydroepiandrosterone scaffold induced specific inhibition of 5a-R1 activity, whereas those with a cycloaliphatic ester (cyclopropyl, cyclobutyl, or cyclopentyl ring) or an alcohol group at C-3 inhibited the activity of both isozymes. Derivatives with a cyclohexyl or cycloheptyl ester at C-3 showed no inhibitory activity. In pharmacological experiments, derivatives with esters having an alcohol or the aliphatic group or one of the three smaller cycloaliphatic rings at C-3 decreased the diameter of male hamster flank organs, with the cyclobutyl and cyclopentyl esters exhibiting higher effect. With exception of the cyclobutyl and cyclopentyl esters, these compounds reduced the weight of the prostate and seminal vesicles.Keywords 5a-R isoenzyme, benign prostatic hyperplasia, dehydroepiandrosterone benzimidazolyl derivative, hamster flank organ, prostate gland History

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Cloning of the hamster androgen receptor gene

Cited by 6 publications

References 21 publications

Molecular interactions of natural and synthetic steroids in female hamsters’ flank organs

Molecular interactions of natural and synthetic steroids in female hamsters’ flank organs

Steroids with a carbamate function at C-17, a novel class of inhibitors for human and hamster steroid 5α-reductase

Novel dehydroepiandrosterone benzimidazolyl derivatives as 5α-reductase isozymes inhibitors

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