2011
DOI: 10.1016/j.fsi.2010.09.014
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Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains

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Cited by 76 publications
(31 citation statements)
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“…The activation of NOD receptors leads to recruitment and association with RIP2 kinase (RIP2K) through CARD-CARD domain interaction, and Glu-69, Asp-70, and Glu-71 amino acid residues of CARD domain of NOD2 are critical for mediating NOD2 interaction with RIP2K (30 -33). Thus, RIP2K forms a crucial link in signal transduction downstream of NLR2 (34,35). From this perspective, we have addressed critical involvement of NLR2 signaling to surmount CTLA-4-or TGF-␤-mediated DC maturation in combination with TLR2 signaling.…”
Section: Tlr2 and Nod Receptors Cooperativelymentioning
confidence: 99%
“…The activation of NOD receptors leads to recruitment and association with RIP2 kinase (RIP2K) through CARD-CARD domain interaction, and Glu-69, Asp-70, and Glu-71 amino acid residues of CARD domain of NOD2 are critical for mediating NOD2 interaction with RIP2K (30 -33). Thus, RIP2K forms a crucial link in signal transduction downstream of NLR2 (34,35). From this perspective, we have addressed critical involvement of NLR2 signaling to surmount CTLA-4-or TGF-␤-mediated DC maturation in combination with TLR2 signaling.…”
Section: Tlr2 and Nod Receptors Cooperativelymentioning
confidence: 99%
“…There is increasing evidence for the involvement of the fish PRRs genes under conditions of viral infection and other induction such as poly I:C [38,39,42,43]. Also, it has been reported that VHSV (viral hemorrhagic septicemia virus 23/75, a negative single-stranded RNA virus) infection significantly up-regulated the expression of RIG-I [18].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, since an NLR family member (NOD2) in rainbow trout induces interferon gene expression, especially IFN-g [29], IFNg gene expression was also examined. TNFa gene expression was induced by LPS in HINAE cells transfected with empty constructs although IFN-g and IL-1b transcripts didn't show sufficient increase in expression in the control cells (Fig.…”
Section: Induction Of Inflammatory Cytokine Gene Expressions By Jfnlrmentioning
confidence: 99%