Cloning the uteroglobin gene promoter from the relic volcano rabbit (<i>Romerolagus diazi</i>) reveals an ancient estrogen‐response element

Acosta-MontesdeOca, Adriana; Zariñán, Teresa; Macías, Héctor Corominas; Pérez‐Solis, Marco Allán; Ulloa‐Aguirre, Alfredo; Gutiérrez-Sagal, Rubén

doi:10.1002/mrd.22030

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Serum levels of uteroglobin, a small globular protein with reported anti‐inflammatory activity, were lower in females with PCOS compared to healthy controls. Interestingly, experimental data show that estrogen transcriptionally controls the uteroglobin gene . Further examining the correlation between estrogen and uteroglobin levels was beyond the scope of the present study and constitutes a future perspective.…”

Section: Discussionmentioning

confidence: 84%

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Polycystic Ovary Syndrome and Insulin Physiology: An Observational Quantitative Serum Proteomics Study in Adolescent, Normal‐Weight Females

Manousopoulou

Al‐Daghri

Sabico

et al. 2019

Proteomics Clinical Apps

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Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with insulin resistance, even in the absence of overweight/obesity. The aim of the present study is to examine the global serum proteomic profile of adolescent, normal‐weight females with PCOS in order to gain novel insight in the association of this endocrine disorder with insulin physiology and to identify novel circulating markers that can guide intervention protocols. Methods Non‐depleted serum from normal‐weight (BMI: 18–23 kg m−2), adolescent females (13–21 years old) with PCOS (n = 20) is compared to BMI‐ and age‐matched healthy controls (n = 20) using our 3D quantitative proteomics methodology. Serum samples from study participants are randomly pooled to form four biological replicates of females with PCOS and four of healthy controls (n = 5 per sample pool). Results One‐hundred and twenty‐six proteins are differentially expressed in females with PCOS compared to controls. Gene ontology analysis shows significant enrichment for terms related to inflammatory immune response, metabolism and insulin‐like growth factor receptor signaling pathway. Circulating levels of IGF‐1 and ‐2 and IGFBP‐2, ‐3, and ‐4 are found to be lower in females with PCOS compared to healthy controls. Conclusions The present serum proteomics study provides insight into the pro‐inflammatory status and insulin dysregulation in young females with PCOS and identifies potential serological markers that can guide early intervention protocols.

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Section: Discussionmentioning

confidence: 84%

“…Interestingly, experimental data show that estrogen transcriptionally controls the uteroglobin gene. [19,20] Further examining the correlation between estrogen and uteroglobin levels was beyond the scope of the present study and constitutes a future perspective.…”

Section: Discussionmentioning

confidence: 94%

Polycystic Ovary Syndrome and Insulin Physiology: An Observational Quantitative Serum Proteomics Study in Adolescent, Normal‐Weight Females

Manousopoulou

Al‐Daghri

Sabico

et al. 2019

Proteomics Clinical Apps

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“…This species distributed in South Africa is endemic to central Karoo and located in an area < 500 km 2 . The riverine rabbit inhabits riparian vegetation on alluvial soils adjacent to seasonal rivers, but its habitat has been highly fragmented and transformed (60 %).…”

Section: Critically Endangered Speciesmentioning

confidence: 99%

State of knowledge and conservation of endangered and critically endangered lagomorphs worldwide

Lorenzo

Rioja-Paradela²,

Carrillo-Reyes³

2015

Therya

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Introduction: Lagomorphs (rabbits, hares, and pikas) are widely distributed in every continent of the world, except Antarctica. They include 91 species: 31 rabbits of the genera Brachylagus, Bunolagus, Caprolagus, Nesolagus, Pentalagus, Poelagus, Prolagus, Pronolagus, Romerolagus, and Sylvilagus;32 hares of the genus Lepus and 28 pikas of the genus Ochotona. According to the International Union for Conservation of Nature (IUCN 2014), the list of threatened species of lagomorphs includes one extinct, three critically endangered, ten endangered, five near threatened, five vulnerable, 61 of least concern, and six with deficient data. Although a rich diversity of lagomorphs and endemic species exists, some of the wild populations have been declining at an accelerated rate, product of human activities and climate change. In order to evaluate specific conservation actions for species at risk in the near future, the aim of this study is to determine the state of knowledge of endangered and critically endangered species and conservation proposals based on recent studies. This work should serve as a starting point for proposing management and habitat conservation plans for these species and filling the information gaps to address them as soon as possible. Methods:We performed an analysis of the recent trends in the state of knowledge of worldwide endangered and critically endangered lagomorphs, based on the compilation of the recent bibliographic citations in the IUCN list of endangered species (2014), the Lagomorphs Specialist Group of the IUCN web page, and on published studies focusing on these species. Each study was divided into various topics to know those that need to be addressed. We show detailed information for species that are at risk of extinction in the near future (critically endangered and endangered categories), describing the threats to their populations and existing conservation proposals.Results: A total of 13 endangered and critically endangered species of lagomorphs have been the subject of study with a total of 78 contributions, of which the most frequently represented (25) refer to phylogeny, systematics, taxonomy, and evolution, followed by conservation (18), and ecology (14); the least represented are studies of reproduction and morphology with only one each. The critically endangered and endangered species have restricted distributions and in general, their threat factors are introduction of exotic species; habitat loss due to development of human settlements and productive activities; induced fires for the growth of new grass shoots for livestock; poaching; and the presence of predators and feral dogs. Discussion and Conclusions:Worldwide human activities have affected the survival of species of lagomorphs, especially those with restricted distributions. Less than 55 % (7 species) of the total number of species of endangered and critically endangered lagomorphs has been subject of specific study in recent works (2011 to date); moreover, in some cases only one publication was found. Although re...

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Estrogen-regulated transcription of the uteroglobin gene from the brown hare (Lepus capensis)

Acosta-MontesdeOca

Zariñán

Ulloa‐Aguirre

et al. 2014

General and Comparative Endocrinology

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Cloning the uteroglobin gene promoter from the relic volcano rabbit (Romerolagus diazi) reveals an ancient estrogen‐response element

Cited by 4 publications

References 32 publications

Polycystic Ovary Syndrome and Insulin Physiology: An Observational Quantitative Serum Proteomics Study in Adolescent, Normal‐Weight Females

Polycystic Ovary Syndrome and Insulin Physiology: An Observational Quantitative Serum Proteomics Study in Adolescent, Normal‐Weight Females

State of knowledge and conservation of endangered and critically endangered lagomorphs worldwide

Estrogen-regulated transcription of the uteroglobin gene from the brown hare (Lepus capensis)

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