Cloricromene

Squadrito, Francesco; Prosdocimi, Marco; Altavilla, Domenica; Zingarelli, Basilia; Caputi, Achille P.

doi:10.1111/j.1527-3466.1991.tb00421.x

Cited by 18 publications

(17 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cloricromene causes changes in the throm boxane-prostacyclin equilibrium at the level of the vascular wall [14][15][16][17] and inhibits the thrombocytic activation and aggregation in duced by various stimuli such as arachidonic acid, collagen, ADP [18,19], adrenaline, or PAF [20] or by a combination of the stimuli [21,22].…”

Section: Discussionmentioning

confidence: 99%

Effects of Cloricromene on the Levels of Endothelin and on the Microcirculatory Function in Peripheral Atherosclerotic Arteriopathies

Saitta

Bonaiuto²,

Giordano³

et al. 1996

Pharmacology

Self Cite

View full text Add to dashboard Cite

The effects of cloricromene on plasma endothelin-1 (ET-1) levels and on microcirculatory function in 9 patients with peripheral atherosclerotic arteriopathy (PAA) and in healthy control subjects were studied. ET-1 levels and microcirculatory function were evaluated both under basal conditions and 30, 60, and 90 min after acute administration of cloricromene (30 mg i.v.). PAA patients had significantly increased levels of ET-1 and impaired vascular parameters (studied by means of Winsor’s Index, Gosling’s Index, postischemic perfusion index and recovery time) when compared to control subjects. The acute administration of cloricromene (30 mg i.v.) did not change plasma ET-1 both in control subjects and in patients with PAA. In contrast, cloricromene produced a significant improvement in the postischemic perfusion index and in recovery time in arteriopathic patients. Control subjects and patients with PAA also underwent a cold pressor test (CPT) under basal conditions and (72 h later) 30 min after an acute intravenous administration of cloricromene (30 mg i.v.). CPT caused a higher increase in ET-1 in the patients with PAA compared to the control group, and a reduction in the vascular flow at the femoral level, while the pretreatment with cloricromene prevented both the increase in the levels of ET-1 and the reduction of the femoral vascular flow observed after the cold stimulus in patients with PAA. Our data show that cloricromene, besides ameliorating the microcirculatory function, is able to interfere with dynamic mechanisms, such as those induced by the CPT, capable of stimulating the release of ET-1 at the vascular level.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Cloricromene on the Levels of Endothelin and on the Microcirculatory Function in Peripheral Atherosclerotic Arteriopathies

Saitta

Bonaiuto²,

Giordano³

et al. 1996

Pharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The acid metabolite cannot enter the cells when given as such and essentially is inactive in other biological tests performed (Squadrito et al, 1991).…”

Section: Effect Of Cloricromene On the Different Pathways Of Monocytementioning

confidence: 99%

“…This compound may induce a general inhibitory activity on platelets and polymorphonuclear leukocytes (Squadrito et al, 1991) possibly through its ability to modulate the levels of biochemical messengers which regulate cellular response. Cloricromene is able to reduce platelet response by reducing cytoplasmic…”

Section: Effect Of Cloricromene On the Different Pathways Of Monocytementioning

confidence: 99%

Inhibition of human monocyte adhesion to endothelial cells by the coumarin derivative, cloricromene

Tranchina

Bernasconi

Dejana

et al. 1994

British J Pharmacology

View full text Add to dashboard Cite

The ability of the coumarin derivative cloricromene (8‐monochloro‐3‐β‐diethylaminoethyl‐4‐methyl‐7‐ethoxy‐carbonylmethoxycoumarin) to inhibit monocyte adhesion to human cultured umbilical vein endothelial cells (HUVEC) was investigated. Cloricromene (10–200 μm) inhibited, in a concentration‐dependent manner, the adhesion of both resting and activated monocytes to HUVEC. Significant inhibition was reached with drug concentrations ranging between 15 to 30 μm. The inhibitory activity was, at least in large part, directed to monocytes since no inhibition was observed after selective preincubation of HUVEC with cloricromene and the drug maintained its effect also on monocyte adhesion to paraformaldehyde‐treated HUVEC. Inhibition was maximal after 1 min of exposure of monocytes to cloricromene and persisted even in the absence of the drug. Both basal and chemoattractant‐mediated monocyte adhesion was inhibited by cloricromene as it was by TS1/18, a monoclonal antibody (mAb) directed to β2 integrins; however, cytofluorimetric analysis showed that cloricromene was unable to modulate the expression of β2 integrins on the monocyte surface. When monocyte adhesion was mediated by a large set of adhesive receptors, as obtained after treatment of HUVEC with either interleukin 1β (IL‐1; 50 ng ml−1) or tumour necrosis factor‐α (TNF; 100 u ml−1), the inhibitory effect of cloricromene was considerably reduced. The results of this study show that cloricromene may regulate monocyte adhesion to HUVEC, an event relevant in vivo in the pathogenesis of inflammatory and atherosclerotic processes.

show abstract

“…We designed the present study for this reason using cloricromene which is reported to be without effects, at least at pharmacological doses, on conventional blood coagulation parameters (for review see Squadrito et al, 1991), in a rat model of experimental colitis induced with dinitrobenzenesulphonic acid (DNB) also investigating, besides conventional parameters concentrations of macrophage inflammatory protein-2 (MIP-2) and TNF-a and coagulation indices.…”

Section: Introductionmentioning

confidence: 99%

A protective effect of the synthetic coumarine derivative Cloricromene against DNB-colitis in the rat

et al. 2004

View full text Add to dashboard Cite

Cloricromene

Cited by 18 publications

References 29 publications

Effects of Cloricromene on the Levels of Endothelin and on the Microcirculatory Function in Peripheral Atherosclerotic Arteriopathies

Effects of Cloricromene on the Levels of Endothelin and on the Microcirculatory Function in Peripheral Atherosclerotic Arteriopathies

Inhibition of human monocyte adhesion to endothelial cells by the coumarin derivative, cloricromene

A protective effect of the synthetic coumarine derivative Cloricromene against DNB-colitis in the rat

Contact Info

Product

Resources

About