Close Association of Regional Interleukin-6 Levels in the Infarct-Related Culprit Coronary Artery With Restenosis in Acute Myocardial Infarction

Funayama, Hiroshi; Ishikawa, San‐e; Kubo, Norifumi; Yasu, Takanori; Saito, Muneyasu; Kawakami, Masanobu

doi:10.1253/circj.70.426

Cited by 20 publications

(9 citation statements)

References 23 publications

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“…In addition, in patients with reperfused myocardial infarction, circulating IL-6 levels closely correlate with left ventricular geometric changes during the remodeling process [23]. Funayama et al [24] found that after percutaneous coronary intervention (PCI), local IL-6 levels in the culprit coronary artery strongly correlated with future re-stenosis of recanalized coronary artery in acute myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-6, but Not Soluble Adhesion Molecules, Predicts a Subsequent Mortality from Cardiovascular Disease in Patients with Acute ST-Segment Elevation Myocardial Infarction

Fan

Hua

et al. 2011

Cell Biochem Biophys

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Inflammatory responses are an important element in the atherosclerotic process. Therefore, inflammatory markers can potentially serve as predictors of cardiovascular risk. However, the existing data are limited and controversial. We conducted a prospective cohort study with 263 patients with first acute ST-segment elevation myocardial infarction (STEMI) who were admitted to our Hospital within 6 h after the symptoms onset. Clinical data were recorded and serum admission levels of interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble P-selectin (sP-selectin) were determined. The patients were then followed up for 3 years to document cardiovascular mortality. During the follow-up, 34 patients died from cardiovascular causes. The admission levels of IL-6 were significantly higher in these patients, whereas sICAM-1, sVCAM-1, and sP-selectin were comparable between these and the survived patients. The Kaplan-Meier plots revealed a significant increase in cardiovascular mortality with increasing levels of IL-6 (P = 0.0002, χ(2) test). The logistic regression analysis indicated that IL-6 was an independent predictor for cardiovascular mortality. To conclude, our findings indicate that elevated admission levels of IL-6, but not soluble adhesion molecules, provide valuable information for risk assessment of long-term cardiovascular mortality in patients with STEMI.

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Section: Discussionmentioning

confidence: 99%

Interleukin-6, but Not Soluble Adhesion Molecules, Predicts a Subsequent Mortality from Cardiovascular Disease in Patients with Acute ST-Segment Elevation Myocardial Infarction

Fan

Hua

et al. 2011

Cell Biochem Biophys

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“…In a subsequent study, they demonstrated an association between elevated postpercutaneous coronary intervention coronary artery IL-6 concentrations and late coronary artery restenosis. 80 …”

Section: Critical Carementioning

confidence: 99%

Interleukin-6 in Surgery, Trauma, and Critical Care Part II: Clinical Implications

Jawa

Anillo

Huntoon

et al. 2010

J Intensive Care Med

184

112

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A variety of cytokines play a role in the inflammatory response. Interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus, and act locally and systemically to generate a variety of physiologic responses. Interleukin-6 concentrations are elevated after surgery, trauma, and critical illness. The magnitude of IL-6 elevation correlates with the extent of tissue trauma/injury severity. Furthermore, there is an association between IL-6 elevation and adverse outcome. Interleukin-6 levels can also be used to stratify patients for therapeutic intervention.

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“…IL‐6 promoter polymorphism is associated with the 12 month restenosis risk after femoral‐popliteal percutaneous transluminal angioplasty (PTA) [116]. The levels of plasma IL‐6 pre‐ and poststage PCI are significantly greater in patients with restenosis than in those without restenosis [117]. The release of IL‐8 after PCI is a powerful prognostic factor for restenosis [118].…”

Section: Factors Involved In Restenosismentioning

confidence: 99%

Do Statins have a Role in Reduction/Prevention of Post‐PCI Restenosis?

Prasad

2011

Cardiovascular Therapeutics

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SUMMARYThe pathophysiology of post-PCI restenosis involves neointimal formation that consists of three phases: thrombosis (within 24 h), recruitment (3-8 days), and proliferation, which starts on day 8 of PCI. Various factors suggested to be predictors/risks for restenosis include C-reactive protein (CRP), inflammatory mediators (cytokines and adhesion molecules), oxygen radicals, advanced glycation end products (AGEs) and their receptors (RAGE), and soluble RAGE (sRAGE). The earlier noted factors produce thrombogenesis, vascular smooth muscle cell proliferation, and extracellular matrix formation. Statins have pleiotropic effects. Besides lowering serum cholesterol, they have various other biological effects including antiinflammatory, antithrombotic, CRP-lowering, antioxidant, antimitotic, and inhibition of smooth muscle cell proliferation. They inhibit matrix metalloproteinase and cyclooxygenase-2, lower AGEs, decrease expression of RAGE and increase levels of serum sRAGE. They also increase the synthesis of nitric oxide (NO) by increasing endothelial NO synthase expression and activity. Preprocedural statin therapy is known to reduce peri-and post-PCI myonecrosis and reduce the need for repeat revascularization. There is evidence that statin-eluting stents inhibit in-stent restenosis in animal models. It is concluded that because of the above attributes of statins, they are suitable candidates for reduction of post-PCI restenosis and post-PCI myonecrosis. The future directions for the use of statins in reduction of post-PCI restenosis and myonecrosis have been discussed.

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Close Association of Regional Interleukin-6 Levels in the Infarct-Related Culprit Coronary Artery With Restenosis in Acute Myocardial Infarction

Cited by 20 publications

References 23 publications

Interleukin-6, but Not Soluble Adhesion Molecules, Predicts a Subsequent Mortality from Cardiovascular Disease in Patients with Acute ST-Segment Elevation Myocardial Infarction

Interleukin-6, but Not Soluble Adhesion Molecules, Predicts a Subsequent Mortality from Cardiovascular Disease in Patients with Acute ST-Segment Elevation Myocardial Infarction

Interleukin-6 in Surgery, Trauma, and Critical Care Part II: Clinical Implications

Do Statins have a Role in Reduction/Prevention of Post‐PCI Restenosis?

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