Close Association of Streptococcus sanguis Uncommon Serotypes with Behcet's Disease

Abstract

This is a description of the role of Streptococcus sanguis in the oral flora of patients with Behcet's disease (BD) in contrast to the flora of healthy controls. The proportion of S. sanguis in the flora of patients with BD was always higher than that of healthy and disease controls. The types of S. sanguis in the oral flora of the BD patients were uncommon ones. Agglutinating antibody titers against isolated strains of S. sanguis were higher in BD patients than in controls. When S. sanguis antigens were used in skin reaction, the erythema of skin in BD patients was greater than that in healthy controls. It is proposed that uncommon serotypes of S. sanguis may play a role in the pathogenesis of BD.

Characterization of Streptococcus sanguis Isolated from Patients with Behçet's Disease

“…The patients show hypersensitivity in skin tests with streptococcal antigens, and sometimes symptoms typical of BD are provoked by an injection of these antigens (16). We found that the proportion of Streptococcus sanguis in the oral flora of BD patients significantly increased as compared with the controls and that the antigenicity of S. sanguis strains isolated from BD was different from that of the three type and reference strains of ATCC (ATCC10556T, ATCC10557, and ATCC10558T) as well as the S. sanguis strains isolated from patients with Kawasaki disease (designated as MCLS-1 and MCLS-2) (9,15 (3). They found that the cultures which were considered to be S. sanguisfrom their biochemical properties could be divided into two genetic groups (groups 1 and 3).…”

Tonsillectomy to Effectively Treat a Patient with Behçet's Disease

“…Isogai et al (12) reported that the flora of BD patients showed a greater proportion of S. sanguinis. In addition, they reported that an uncommon type of S. sanguinis was found in all BD cases.…”

Behcet’s Disease and Related Diseases -Immune Reactions to Oralstreptococci in Their Pathogenesis

“…Generally, the oral health is impaired in BD patients with the disease severity [11][12][13]15,16] . The antibodies against S. sanguinis showed cross reactivity with the synthetic peptides of HSP-65 derived from the There are some reports that BD patients associated with HLA-B51 show much stronger reaction to "Pathergy test".…”

“…Although the actual etiology of BD is still unclear, the pathogenesis has been generally clearer by the etiological studies based on the genetic intrinsic factors and extrinsic triggering factors [5][6][7][8][9][10][11][12][13][14][15][16] . As one of the triggering factors, the oral unhygienic condition may be suspected, because periodontitis, decayed teeth, chronic tonsillitis, etc.…”

“…The proportion of Streptococcus sanguinis (S. sanguinis), which was previously recognized as species of the genus Streptococcus named "S. sanguis", was significantly high in the oral bacterial flora of BD patients in comparison with those of healthy controls. S. sanguinis from BD patients was identified as uncommon serotype KTH-1 (so-called by the bacterial and enzymatic properties [14][15][16] . Most of BD patients tend to acquire hypersensitivity against streptococci in their oral flora, as previously demonstrated that the cutaneous reactions by the injection and/or prickle with bacteria antigens of streptococci and enterococci were much stronger than the reaction by "Pathergy test".…”