Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Abstract

A self-regulated dynamic nanohybrid that can sensitively respond to hyperglycemic microenvironment is developed. The nanohybrid with a core/shell structure is produced through a single-step microfluidics nanoprecipitation method, where drugs-loaded porous silicon (PSi) nanoparticles are encapsulated by H2O2 responsive polymeric matrix.

Microfluidics for Production of Particles: Mechanism, Methodology, and Applications

“…Comparing to the pristine NPs, the newly produced core/shell nanohybrids obtained a better human plasma stability (aggregation time 5 min vs 120 min), a reduced toxicity toward normal fibroblast cells (3T3), but an enhanced targeting ability toward human breast cancer (MCF‐7). Liu et al encapsulated atorvastatin loaded porous silicon (PSi) NPs with a reactive oxygen species (ROS)‐responsive polymer, 4‐(hydroxymethyl)‐phenylboronic acid pinacol ester conjugated oxidized dextran (POD) and further applied the nanosystem for diabetic wound healing . The major obstacle for porous materials, burst payload release, can be overcome by the polymeric shell formation and the release kinetics can be feasibly tailored by the choice of the shell material, as the release of atorvastatin can only be triggered with the coexistence of overproduced ROS, and the release rate can be sustained for over 24 h, making the core materials more suitable for envisioned biomedical applications.…”

Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation

“…Among these strategies, the introduction of bioactive nanoparticles can actively regulate the mechanical behavior of hydrogels and their degradation kinetics as well as providing novel functionalities (e.g., osteogenic and antibacterial activities) [ 9 , 10 ]. Various types of nanoparticles have been applied as bioactive fillers to enhance the properties of hydrogels, such as silica nanoparticles [ 11 ] and silicon nanoparticles [ 12 ]. Bioactive glass nanoparticles (BGNs) are attracting increasing attention as building blocks for developing nanocomposites and hybrids, considering their controllable particle size/shape, bioreactivity, and degradation rate that can lead to superior biocompatibility, bioactivity, osteogenic and angiogenic activities [ 13 , 14 ].…”

Microfluidics for core–shell drug carrier particles – a review

“…65 An encapsulated atorvastatin loaded porous silicon (PSi) NPs with a reactive oxygen species (ROS) was applied for diabetic wound healing. 84 As it was mentioned, the polymeric shell formation can solve burst payload release, which is the main barrier for porous materials. The release kinetics can be easily adjusted by the shell material's choice, as the release of atorvastatin can be stimulated only by the coexistence of overproduced ROS.…”