Close Positive Correlation between the Lymphocyte Response to Hen Egg White and House Dust Mites in Infants with Atopic Dermatitis

Kimura, Mitsuaki; Meguro, Takaaki; Ito, Yasunori; Tokunaga, Fumika; Hashiguchi, Akihiko; Seto, Shiro

doi:10.1159/000381057

Cited by 10 publications

(10 citation statements)

References 18 publications

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“…Serum levels of HDM-specific IgE are significantly correlated with lymphocyte stimulation index. These results support the hypothesis that both food and indoor allergens concurrently sensitize infants via the skin [139]. …”

Section: Clinical Pictures: Asthma Rhinitis/rhinosinusitis Atopic Dsupporting

confidence: 87%

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International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem

Sánchez‐Borges

Fernández-Caldas

Thomas

et al. 2017

World Allergy Organization Journal

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Since mite allergens are the most relevant inducers of allergic diseases worldwide, resulting in significant morbidity and increased burden on health services, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), formed by the American Academy of Allergy, Asthma and Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI), the European Academy of Allergy and Clinical Immunology (EAACI), and the World Allergy Organization (WAO), has proposed to issue an International Consensus (ICON) on the clinical consequences of mite hypersensitivity. The objectives of this document are to highlight aspects of mite biology that are clinically relevant, to update the current knowledge on mite allergens, routes of sensitization, the genetics of IgE responses to mites, the epidemiologic aspects of mite hypersensitivity, the clinical pictures induced by mites, the diagnosis, specific immunotherapeutic approaches, and prevention.

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Section: Clinical Pictures: Asthma Rhinitis/rhinosinusitis Atopic Dsupporting

confidence: 87%

“…This accelerates inflammation, but does not necessarily result in specific sensitization [37]. Mite allergens can activate keratinocytes and induce them to produce and secrete pro-inflammatory cytokines [137–139]. Allergens may sensitize infants with AD via the skin.…”

Section: Clinical Pictures: Asthma Rhinitis/rhinosinusitis Atopic Dmentioning

confidence: 99%

International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem

Sánchez‐Borges

Fernández-Caldas

Thomas

et al. 2017

World Allergy Organization Journal

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“…DFE is known to contribute to the development of AD via the activation of inflammasomes in the epidermal keratinocytes [1,32]. Previous research showed that repeated application of DFE produced AD symptoms, including epidermis thickening, fibrosis in the dermis and the infiltration of inflammatory cells (eosinophils and mast cells) [33].…”

Section: Discussionmentioning

confidence: 99%

1,2,4,5-Tetramethoxybenzene Suppresses House Dust Mite-Induced Allergic Inflammation in BALB/c Mice

Jin

Choi²,

Choi³

et al. 2016

Int Arch Allergy Immunol

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Background: Atopic dermatitis (AD) is the most common allergic inflammatory skin disease. The activation of innate immunity by house dust mite (Dermatophagoides farinae extract, DFE) allergen plays an important role in the pathogenesis of AD. We previously showed the inhibitory effect of an extract of Amomum xanthioides on allergic diseases, and isolated 1,2,4,5-tetramethoxybenzene (TMB) as a major active component. In this study, we investigated whether TMB relieves DFE-induced allergic inflammation symptoms. Methods: We established a DFE-induced allergic inflammation model in BALB/c mice by repeated skin exposure to DFE. To define the underlying mechanisms of action, we used a tumor necrosis factor-α and interferon-γ-activated human keratinocytes (HaCaT cell line) and mouse keratinocytes (3PC cell line) cell line model. Results: Oral administration of TMB suppressed allergic inflammation symptoms, such as histopathological analysis and ear thickness, in addition to serum IgE, DFE-specific IgE and IgG2a levels. TMB decreased the serum histamine levels and tissue infiltration of inflammatory cells, including mast cells and eosinophils. TMB also inhibited CD4⁺IFN-γ⁺, CD4⁺IL-4⁺, and CD4⁺IL-17A⁺ lymphocyte expansion in the draining lymph nodes and expression of the Th2 cytokines in the ear tissue. TMB significantly inhibited the expression of cytokines and chemokines by the downregulation of the mitogen-activated protein kinases and nuclear factor of activated cytoplasmic T cells in HaCaT cells. Conclusions: TMB improved DFE-induced allergic inflammation by suppressing the production of proinflammatory cytokines and chemokines. Our results suggest that TMB might be a potential therapeutic agent for AD.

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“…The CM‐sIgE level was measured using the ImmunoCAP system (Thermo Fisher Scientific, Tokyo, Japan), and ≥0.35 kU/L was regarded as positive. Allergen‐specific lymphocyte stimulation test (ALST) was also performed using flow cytometry or radioisotopes …”

Section: Methodsmentioning

confidence: 99%

Prognosis of infantile food protein‐induced enterocolitis syndrome in Japan

Kimura

Shimomura

Morishita

et al. 2017

Pediatrics International

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Background: Although serum C-reactive protein (CRP) and the percentage of eosinophils in peripheral blood (Eo) are increased at onset in infants with food protein-induced enterocolitis syndrome (FPIES), the relationship of these laboratory findings to prognosis is presently unknown. Methods: Correlation of serum CRP and Eo at onset with prognosis was analyzed in 32 patients with FPIES caused by cow's milk (CM).Results: The rate of tolerance acquisition was 18.8%, 56.3%, 87.5%, and 96.9% at the ages of 6, 12, 24, and 36 months, respectively. Serum CRP increased in 50% of subjects at onset (median, 0.21 mg/dL; range, <0.20-18.2 mg/dL) and Eo was elevated in 71.9% of subjects at onset (median, 7.1%; range, 1.0-50.5%). Age at tolerance acquisition was significantly positively correlated with serum CRP at onset (r = 0.45, P < 0.01), and significantly negatively correlated with Eo at onset (r = À0.36, P < 0.05). Although CM-specific immunoglobulin E antibody (sIgE) was positive in nine of 32 FPIES patients at onset (median, 0.93; range, 0.38-18.9 kU/L), it decreased thereafter. CM-sIgE at onset did not correlate significantly with prognosis (r = 0.22, P > 0.05).Conclusions: Serum CRP is not only an indicator of the activity of intestinal inflammation, it is also a useful parameter of poor prognosis in FPIES. In contrast, eosinophilia at onset could be used as a marker of good prognosis, suggesting that it has some beneficial effects in the pathophysiology of FPIES.

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Close Positive Correlation between the Lymphocyte Response to Hen Egg White and House Dust Mites in Infants with Atopic Dermatitis

Cited by 10 publications

References 18 publications

International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem

International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem

1,2,4,5-Tetramethoxybenzene Suppresses House Dust Mite-Induced Allergic Inflammation in BALB/c Mice

Prognosis of infantile food protein‐induced enterocolitis syndrome in Japan

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