“…[1][2][3] Tremendous efforts have been made to create artificial molecules to mimic biomolecules, structurally or functionally. Among them, cage molecules are known as important molecular recognition mimics and are widely applied across multiple disciplines, [11][12][13][14][15][16] such as molecular separation, [17][18][19] catalysis, [20][21][22] molecular transport, [23][24][25] biological applications, 26,27 gas adsorption, 28,29 stabilization of species, 30 crystallography, 31 molecular sieves, 32 optoelectronics, 33,34 etc. The properties of a cage largely depend on its confined cavity and settled recognition sites, i.e.…”