Closed Loop Control

Robust model matching control of immune systems under environmental disturbances: Dynamic game approach

“…The dynamics of drug response (pharmacokinetics) have been modeled in several works (Robinson, 1986;Van rossum et al, 1986) and control theory is applied to drug delivery in other studies (Bell and Katusiime, 1980;Carson et al, 1985;Chizeck and Katona, 1985;Jelliffe, 1986;Schumitzky, 1986;Kwong et al, 1995;Polycarpou and Conway, 1995;Parker et al, 1996;Gentilini et al, 2001). Recently, Stengel et al (2002a) presented a simple model for the response of the innate immune system to infection and therapeutic intervention, reviewed the prior method and results of optimization, and introduced a significant extension to the optimal control of enhancing immune response by solving a twopoint boundary-value problem via an iterative method.…”

Cyber-Physical Geographical Information Service-Enabled Control of Diverse In-Situ Sensors

“…CPSs pay much attention to control of sensors in the physical world that are networked and/or distributed, with feedback loops [ 5 , 6 ] in which sensing behaviors affect computations and vice versa [ 7 , 8 ], to bring the output of the sensors back to original or desired response, which can be referred to as closed-loop control [ 9 ]. However, according to analyses in Section 2, current methods of control, when applied to sensors, have the following drawbacks that hinder the development of CPSs: Current control methods lack openness.…”

Robust H∞ Tracking Control of Stochastic Innate Immune System Under Noises

“…Kirschner (Kirschner et al, 1997) offers an optimal control approach to HIV treatment, and intuitive control approaches are presented in (Bonhoeffer et al, 1997;De Boer & Boucher, 1996;Wein et al, 1998;Wodarz & Nowak, 1999. The dynamics of drug response (pharmacokinetics) are modeled in several works (Robinson, 1986;van Rossum et al, 1986) and control theory is applied to drug delivery in other studies (Bell & Katusiime, 1980;Carson et al, 1985;Chizeck & Katona, 1985;Gentilini et al, 2001;Jelliffe, 1986;Kwong et al, 1995;Parker et al, 1996;Polycarpou & Conway, 1995;Schumitzky, 1986). Recently, Stengel (Stengel et al, 2002a) presented a simple model for the response of the innate immune system to infection and therapy, reviewed the prior method and results of optimization, and introduced a significant extension to the optimal control of enhancing the immune response by solving a two-point boundary-value problem via an iterative method.…”