Closed Tibial-Shaft Fractures: Which Ones Benefit From Surgical Treatment?

Lindsey, Ronald W.; Blair, Sloane R.

doi:10.5435/00124635-199601000-00005

Cited by 22 publications

(8 citation statements)

References 37 publications

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“…Its incidence ranges up to 46%, 6,8–12 depending on injury location, bone loss, soft tissue injury, and associated vascular injuries. Other risk factors for nonunion include: fracture type, 13 surgical technique, 14 infection, 15 and patient-related factors such as age, 9 co-morbidities, 16–18 tobacco use, 19,20 diet, and alcohol consumption. 17 …”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Use of Serological Bone Formation Markers to Monitor Callus Development and Fracture Healing

Coulibaly

Sietsema

Burgers

et al. 2010

Crit Rev Eukar Gene Expr

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The failure of an osseous fracture to heal, or the development of a nonunion, is common; however, current diagnostic measures lack the capability of early and reliable detection of such events. Analyses of radiographic imaging and clinical examination, in combination, remain the gold standard for diagnosis; however, these methods are not reliable for early detection. Delayed diagnosis of a nonunion is costly from both the patient and treatment standpoints. In response, repeated efforts have been made to identify bone metabolic markers as diagnostic or prognostic tools for monitoring bone healing. Thus far, the evidence regarding a correlation between the kinetics of most bone metabolic markers and nonunion is very limited. With the aim of classifying the role of biological pathways of bone metabolism and of understanding bone conditions in the development of osteoporosis, advances have been made in our knowledge of the molecular basis of bone remodeling, fracture healing, and its failure. Procollagen type I amino-terminal propeptide has been shown to be a reliable bone formation marker in osteoporosis therapy and its kinetics during fracture healing has been recently described. In this article, we suggest that procollagen type I amino-terminal propeptide presents a good opportunity for early detection of nonunion. We also review the role and potential of serum PINP, as well as other markers, as indications of fracture healing.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in the Use of Serological Bone Formation Markers to Monitor Callus Development and Fracture Healing

Coulibaly

Sietsema

Burgers

et al. 2010

Crit Rev Eukar Gene Expr

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show abstract

“…Acceptable alignment was defined using established parameters which included coronal angulation less than 5 degrees, sagittal angulation less than 10 degrees, rotation less than 5 degrees, shortening less than 1 cm, displacement less than 50% 11 . During the casting phase, the cast would be wedged if alignment was outside of those parameters.…”

Section: Methodsmentioning

confidence: 99%

Modern treatment of tibial shaft fractures: Is there a role today for closed treatment?

Swart

Lasceski

Latario

et al. 2021

Injury

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Paper Highlights Attempted closed treatment of isolated tibial shaft fractures has a 70% rate of conversion to surgery. Coronal/sagittal translation, sagittal angulation, fracture morphology, and smoking status were shown to be significant predictors of success of nonoperative treatment. There is a cohort of over 1/3 of isolated closed tibial shaft fracture that can be treated nonsurgically with a success rate over 60%.

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“…По данным различных авторов, частота несращений достигает более 46% [49][50][51][52][53][54] и зависит от локализации повреждения, степени потери костной массы, повреждения мягких тканей и сосудов. Имеются и другие факторы риска несращений: тип перелома [55], примененный способ хирургического вмеша-тельства [56], наличие инфекции [57], а также индивидуальные особенности пациентов, такие как пожилой возраст [52], нали-чие сопутствующих заболеваний [58,59] табакокурение [2,60], несбалансированная диета, употребление алкоголя [58].…”

Section: маркеры костного метаболизма при нарушении репаративного остunclassified

Markers of Bone Metabolism in Long Bone’s Adhesion

Побел¹,

Bengus²,

Dedukh³

2012

Osteopor Bone Dis

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This review presents the current evidence about the use of markers of bone metabolism in the prediction of fracture healing, differences in concentrations of blood markers of bone metabolism in patients with normal and delayed consolidation of bone fragments. We analyze the relationship between the fracture site, time-stage features of its healing and urinary macromolecules, reflecting bone metabolism. Increase in bone turnover, which is observed after the fracture, is characterized by activation markers of bone resorption, with a subsequent increase in the concentration of blood markers of bone formation. However, there is a marked variability in data concerning the levels of bone markers in plasma at different stages of fracture healing. We show that in patients with delayed fracture healing there is a significant delay in raising osteocalcin levels. Prognostic features for determining fracture nonunion include low concentrations of N-terminal propeptide of procollagen type I. Determination of markers of bone metabolism in blood can serve as informative criterion for the course of reparative osteogenesis, but one must consider the nature of traumatic injury, time passed from injury, especially the state of bone tissue at the time of injury, age of the patient to identify the early stages of consolidation disturbances.

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Closed Tibial-Shaft Fractures: Which Ones Benefit From Surgical Treatment?

Cited by 22 publications

References 37 publications

Recent Advances in the Use of Serological Bone Formation Markers to Monitor Callus Development and Fracture Healing

Recent Advances in the Use of Serological Bone Formation Markers to Monitor Callus Development and Fracture Healing

Modern treatment of tibial shaft fractures: Is there a role today for closed treatment?

Markers of Bone Metabolism in Long Bone’s Adhesion

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