Closely related oxidized phospholipids differentially modulate the physicochemical properties of lipid particles

Kar, Subhabrata; Tillu, Vikas A.; Meena, Shiv Charan; Pande, Abhay H.

doi:10.1016/j.chemphyslip.2010.10.006

Cited by 7 publications

(1 citation statement)

References 30 publications

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“…Since it has been reported that oxidized lipids with different structure and length of the oxidized alkyl chain exerted significantly different effects on the physicochemical properties of the lipid membrane 44,45 , we have compared the effect of oxidized lipids with different structures. Figure 4 shows the experimental data for DOPC bilayer doped with PoxnoPC that has longer alkyl chain compared with POVPC, but with an aldehyde group at its end similar to POVPC.…”

Section: Resultsmentioning

confidence: 99%

Role of Oxidized Lipids in Permeation of H2O2 Through a Lipid Membrane: Molecular Mechanism of an Inhibitor to Promoter Switch

Ouchi

Unoura

Nabika

2019

Sci Rep

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H 2 O 2 permeation through a cell membrane significantly affects living organisms, and permeation is controlled by the physico-chemical nature of lipids and other membrane components. We investigated the molecular relationship between H 2 O 2 permeation and lipid membrane structure using three oxidized lipids. POVPC and PazePC act as intra- and inter-molecular permeation promoters, respectively; however, their underlying mechanisms were different. The former changed the partition equilibrium, while the latter changed the permeation pathway. PoxnoPC inhibited permeation under our experimental conditions via an intra-molecular configuration change. Thus, both intra- and inter-molecular processes were found to control the role of oxidized lipids as inhibitors and promoters towards H 2 O 2 permeation with different mechanisms depending on structure and composition. Here, we identified two independent H 2 O 2 permeation routes: (i) permeation through lipid membrane with increased partition coefficient by intra-molecular configurational change and (ii) diffusion through pores (water channels) formed by inter-molecular configurational change of oxidized lipids. We provide new insight into how biological cells control permeation of molecules through intra- and inter-molecular configurational changes in the lipid membrane. Thus, by employing a rational design for both oxidized lipids and other components, the permeation behaviour of H 2 O 2 and other ions and molecules through a lipid membrane could be controlled.

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Section: Resultsmentioning

confidence: 99%

Role of Oxidized Lipids in Permeation of H2O2 Through a Lipid Membrane: Molecular Mechanism of an Inhibitor to Promoter Switch

Ouchi

Unoura

Nabika

2019

Sci Rep

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The Chemical Nature of the Polar Functional Group of Oxidized Acyl Chain Uniquely Modifies the Physicochemical Properties of Oxidized Phospholipid-Containing Lipid Particles

et al. 2013

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Oxidative modification of phospholipids generates a variety of oxidized phospholipid (Ox-PL) species which differ considerably in their chemical compositions and molecular structures. Recent results suggest that even closely related Ox-PL species can have considerably different biological effects. However, the molecular mechanism for this is not yet clear. In truncated Ox-PLs (tOx-PLs) the fatty acyl chain is shorter in length than the parent nonoxidized phospholipid molecules and contains a polar functional group(s). In a previous study we showed that two closely related tOx-PL species having a similar polar functional group and differing only in the length of the oxidized fatty acyl chain exerts significantly different effects on the physicochemical properties of the nonoxidized phospholipid particles containing these lipids (Kar et al., Chem Phys Lipids 164:54-61, 2011). In this study we have characterized the effect of polar functional groups of oxidized fatty acyl chain on the physicochemical properties of the nonoxidized phospholipid particles containing these lipids. Our results show that Ox-PL species differing only in the chemical nature of polar functional groups in their oxidized fatty acyl chain modify the properties of nonoxidized phospholipid particles containing them in a distinctive way. These results indicate that different species of Ox-PLs induce unique changes in the physicochemical properties of lipid particles/membranes containing them and that this may lead to their different biological effects.

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Oxidized phospholipid content destabilizes the structure of reconstituted high density lipoprotein particles and changes their function

Kar

Patel

Tripathy

et al. 2012

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Closely related oxidized phospholipids differentially modulate the physicochemical properties of lipid particles

Cited by 7 publications

References 30 publications

Role of Oxidized Lipids in Permeation of H2O2 Through a Lipid Membrane: Molecular Mechanism of an Inhibitor to Promoter Switch

Role of Oxidized Lipids in Permeation of H2O2 Through a Lipid Membrane: Molecular Mechanism of an Inhibitor to Promoter Switch

The Chemical Nature of the Polar Functional Group of Oxidized Acyl Chain Uniquely Modifies the Physicochemical Properties of Oxidized Phospholipid-Containing Lipid Particles

Oxidized phospholipid content destabilizes the structure of reconstituted high density lipoprotein particles and changes their function

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