Closest horizons of Hsp70 engagement to manage neurodegeneration

Venediktov, Artem A.; Bushueva, Olga Yu; Kudryavtseva, Varvara A.; Kuzmin, Egor A.; Moiseeva, Aleksandra V.; Baldycheva, Anna; Meglinski, Igor; Piavchenko, Gennadii A.

doi:10.3389/fnmol.2023.1230436

Cited by 20 publications

(5 citation statements)

References 188 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Белки теплового шока, являясь шаперонами, выполняют в первую очередь защитную функцию, и активация их экспрессии служит компенсаторным механизмом ответа при воспалении, отравлении, инфекциях, гипоксии, голоде, воздействии других стрессовых факторов [71] (рис., блок В). Выявлено участие этих белков в реакциях презентации антигенов [72].…”

Section: белки теплового шокаunclassified

Biomarkers of neuroinflammation in the diagnosis of traumatic brain injury and neurodegenerative diseases: a literature review

Kuzmin,

Shamitko,

Piavchenko

et al. 2024

jour

View full text Add to dashboard Cite

Inflammatory processes accompanied by damage to the cell bodies of neurons are combined into the group of neuroinflammation. At the molecular, cellular and tissue levels, neuroinflammation serves as a sanogenetic response to a variety of injuries, including post-traumatic conditions and neurodegeneration. However, inflammatory changes in long-lived cells such as neurons inevitably trigger a range of adverse effects. As a result, prognosis often depends on the severity of neuroinflammation. In this work, we review the spectrum of biomarkers involved in two key mechanisms of neuroinflammation: immune-mediated and mechanical injury, that have a potential clinical application: cytokines, neurospecific proteins and their proteolysis products, markers of oxidative stress, matrix metalloproteinases and endocrine parameters. Over the past decades, a significant pool of data on neuroinflammation biomarkers has been accumulated and continues to grow, but no consensus has been reached on the actual gradation of their clinical significance. Applied branches of medicine require further systematization of information on biomarkers of neuroinflammation for effective prognostic decisions.

show abstract

Section: белки теплового шокаunclassified

Biomarkers of neuroinflammation in the diagnosis of traumatic brain injury and neurodegenerative diseases: a literature review

Kuzmin,

Shamitko,

Piavchenko

et al. 2024

jour

View full text Add to dashboard Cite

show abstract

“…Some pHibAR-Hub genes increase or decrease their expression in a particular cell type according to metabolic state. Hspa8 is a member of the heat-shock protein 70 (HSP 70) family with roles in autophagy and protein-folding that breaks down functional amyloids in the brain ( 54 ), and has important roles in neuroprotective processes and effects on protein misfolding in neurodegenerative diseases ( 55–61 ). We found that Hspa8 expression is reduced in the 72hr FD condition in glia and GABA neurons, but not in glutamatergic or other neurons ( Fig.…”

Section: Cellular Genetic Programs For Hypothalamic Ffr Responses And...mentioning

confidence: 99%

Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus

Ferris,

Murcia,

Rodriguez

et al. 2024

Preprint

View full text Add to dashboard Cite

Elucidating the genetic basis of mammalian metabolism could help define mechanisms central to health and disease. Here, we define conservedcis-regulatory elements (CREs) and programs for mammalian metabolic control. We delineate gene expression and chromatin responses in the mouse hypothalamus for 7 steps of the Fed-to-Fasted-to-Refed (FFR) response process. Comparative genomics of hibernating versus non-hibernating lineages then illuminatescis-elements showing convergent changes in hibernators. Hibernators accumulated loss-of-function effects for specific CREs regulating hypothalamic FFR responses. Multi-omics approaches pinpoint key CREs, genes, regulatory programs, and cell types in the divergence of hibernating and homeothermic lineages. The refeeding period after extended fasting is revealed as one critical period of chromatin remodeling with convergent genomic changes. This genetic framework is a step toward harnessing hibernator adaptations in medicine.One sentence summaryConvergent signals definecis-regulatory mechanisms behind food scarcity responses and hibernator-homeotherm divergence.

show abstract

“…Hsp70 способствуют устойчивости нейронов к преждевременной деградации [3,4], снижению реакции нейроглии на провоспалительные цитокины [5,6]. Всплеск интереса к разработке фармакологических веществ, служащих индукторами или аллостерическими модификаторами для данного белка в нервной ткани [7], привел к росту числа исследований, посвященных изучению роли Hsp70 в механизме защиты нейронов от повреждения при различных нейродегенеративных заболеваниях, например болезни Альцгеймера или ишемии головного мозга [8]. Тем не менее большинство научных коллективов нацелены на исключительно прикладной результат для быстро реализуемых терапевтических опций, что ограничивает понимание фундаментальных последствий повышенной экспрессии или активности Hsp70 в нейронах и глии in vivo [9].…”

Section: список сокращенийunclassified

Morphofunctional features in mice treated by low and high Hsp70 doses

Piavchenko,

Venediktov,

Kuzmin

et al. 2023

jour

View full text Add to dashboard Cite

Aim. We sought to assess the effects of exogenous Hsp70 (single subcutaneous low- and high-dose injections) on organ structure and functions in adult mice.Materials and methods. We randomized CD1 90-day-old male mice (n = 30) to three groups (10 mice per group). We injected the animals with single subcutaneous saline solution for Group 1 (control), low dose (500 μg/kg) of recombinant human Hsp70 (HspA1A) for Group 2, and high dose (5000 μg/kg) of the Hsp70 for Group 3. We examined the behavior of the mice on Day 3 after the injections (distance traveled, velocity, and bowel movement number). We lethalized the mice on Day 5 with further histological study and morphometrics of cerebral cortex, thymus, spleen, and liver. The statistics included one-factor ANOVA test with post hoc Tukey test.Results. All study groups exhibited no significant difference of behavioral parameters. Some liver sinusoids were wider in control group and Hsp70 500 μg/kg group comparing to Hsp70 5000 μg/kg group. We obtained also data for morphometrics: no difference was found for the number of neurons in ganglionic cerebral cortex, the lymphocytic cellularity difference between thymic cortex and medulla, the number of lymphocytes in white splenic pulp, and the number of hepatocyte nuclei in the liver. Red splenic pulp exhibited 1774,5 ± 24,8, 1623,0 ± 26,7, 1553,6 ± 47,0 macrophages for control, low-dose and high-dose groups, respectively (р < 0,0001). Tukey test showed a significant difference between control group and each of Hsp70 groups 500 μg/kg (р = 0,012) and 5000 μg/kg (р < 0,0001).Conclusion. Our study revealed no negative impact of subcutaneous Hsp70 administration at low and high doses on organ structure and functions in mice.

show abstract

Closest horizons of Hsp70 engagement to manage neurodegeneration

Cited by 20 publications

References 188 publications

Biomarkers of neuroinflammation in the diagnosis of traumatic brain injury and neurodegenerative diseases: a literature review

Biomarkers of neuroinflammation in the diagnosis of traumatic brain injury and neurodegenerative diseases: a literature review

Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus

Morphofunctional features in mice treated by low and high Hsp70 doses

Contact Info

Product

Resources

About