Closing-in behaviour in fronto-temporal dementia

Ambron, Elisabetta; Allaria, Francesca; McIntosh, Robert D.; Sala, Sergio Della

doi:10.1007/s00415-009-5027-4

Cited by 20 publications

(32 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As additional evidence, Conson et al 24 reported that the degree of the closing-in phenomenon is independent of the visuospatial function in patients with corticobasal ganglia degeneration or focal frontal lobe lesions. 22,24 In our study, the closing-in phenomenon was correlated relationship with atrophy of bilateral orbito-frontal areas, which supports the attraction hypothesis that the closing-in phenomenon occurs due to frontal lobe dysfunction as a part of a primitive reflex rather than the compensation hypothesis, which states that it occurs due to visuo-spatial dysfunction associated with the parietal lobe.…”

Section: Discussionsupporting

confidence: 84%

“…They reported that the closing-in phenomenon is correlated with the visuo-spatial functions rather than frontal lobe functions; thus, supporting the compensation hypothesis. 21 In contrast, Ambron et al 22 reported that the closing-in phenomenon occurs increasingly when patients with AD attempt to draw a complex figure. These authors also found no correlation between the degree of complexity and closing-in in patients with fronto-temporal dementia (FTD).…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Anatomical Correlates of the "Closing-In" Phenomenon

Kwon¹,

Lee

Hong

et al. 2015

Dement Neurocognitive Disord

View full text Add to dashboard Cite

Background and Purpose The "closing-in" phenomenon refers to the tendency to copy near or overlap a model while performing figurecopying tasks. The mechanisms underlying the closing-in phenomenon have not been fully elucidated, and previous studies only investigated the mechanisms through neuropsychological tests. We investigated the neuroanatomical correlates of the closing-in phenomenon using voxelbased morphometry (VBM). Methods Thirty-eight patients diagnosed with probable Alzheimer's disease (AD) and 21 normal controls were included. All subjects underwent neuropsychological testing to diagnose dementia and magnetization prepared rapid acquisition gradient echo brain magnetic resonance imaging for the voxel-based statistical analysis. The subjects were asked to copy the modified Luria' s alternating squares and triangles to quantify the closing-in phenomenon. We applied SPM8 for the VBM analysis to detect gray matter loss associated with the closing-in phenomenon. Results The patients with probable AD showed a higher closing-in score than that of the normal control subjects (p<0.0001). The VBM analysis revealed more parietal and temporal atrophy in the patients with AD than that in the normal control group. Moreover, atrophy of the orbito-frontal area was associated with the closing-in phenomenon. Conclusions The closing-in phenomenon is dysfunction while performing figure-copying tasks and is more common in patients with AD. The analysis of the orbito-frontal area, which is associated with inhibiting primitive reflexes, revealed that the closing-in phenomenon is an imitation behavior commonly observed in patients with frontal lobe damage.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 96%

Anatomical Correlates of the "Closing-In" Phenomenon

Kwon¹,

Lee

Hong

et al. 2015

Dement Neurocognitive Disord

View full text Add to dashboard Cite

show abstract

“…One more recent study [25] confirmed that CI is more frequent in AD with respect to VaD patients, and that the two patient groups also tended to show qualitatively different CI phenomena, as AD patients more often overlapped at least one element of the copy onto the model (adherent-CI), whereas VaD patients more often drew close to the model without overlapping onto it (near-CI). On the other hand, one retrospective study showed that CI is as frequent in AD as in FTD patients, but did not provide qualitative observations [187]. Indeed, in a sample of patients with the behavioral variant of FTD, near-CI has been observed more frequently than adherent-CI, and was often (but not obligatorily) associated with other imitation and utilization behaviors [188].…”

Section: Closing-inmentioning

confidence: 96%

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Trojano

Gainotti

2016

JAD

View full text Add to dashboard Cite

Abstract. Drawing is a multicomponential process that can be impaired by many kinds of brain lesions. Drawing disorders are very common in Alzheimer's disease and other forms of dementia, and can provide clinical information for the distinction of the different dementing diseases. In our review we started from an overview of the neural and cognitive bases of drawing, and from a recollection of the drawing tasks more frequently used for assessing individuals with dementia. Then, we analyzed drawing disorders in dementia, paying special attention to those observed in Alzheimer's disease, from the prodromal stages of the amnesic mild cognitive impairment to the stages of full-blown dementia, both in the sporadic forms with late onset in the entorhino-hippocampal structures and in those with early onset in the posterior neocortical structures. We reviewed the drawing features that could differentiate Alzheimer's disease from vascular dementia and from the most frequent forms of degenerative dementia, namely frontotemporal dementia and Lewy body disease. Finally, we examined some peculiar aspects of drawing disorders in dementia, such as perseverations, rotations, and closing-in. We argue that a careful analysis of drawing errors helps to differentiate the different forms of dementia more than overall accuracy in drawing.

show abstract

“…In addition, Ambron et al (2009a;2009b) proposed the assessment of CI independently from CA in order to investigate possible dissociation between these symptoms. Thanks to this method, they were able to classify CI within a more general disturbance of action and to demonstrate that CI can be associated with good constructional skills in some patients with Mild Cognitive Impairment (MCI)(n=13/33 MCI patients with CI (Ambron, McIntosh, Finotto, Clerici, Mariani, & Della Sala 2012a).…”

Section: Section 3)mentioning

confidence: 99%

A critical review of closing-in.

Ambron¹,

Sala²

2017

Neuropsychology

Self Cite

View full text Add to dashboard Cite

When performing complex actions, like graphic copying or imitation of gestures, some patients may perform these actions very close to, or directly on the top of the model. This peculiar behavior, known as closing-in, is the focus of the present literature review, which will provide a critical picture of the research in this field, highlighting the difficulties in defining and assessing closing-in and the contrasting results about the nature and the characteristics of this phenomenon. Most importantly, we will discuss the 2 hypotheses proposed to explain closing-in, namely the compensation and the attraction account, in light of the most recent work. This critical review will provide substantial evidence that closing-in represent a primitive default tendency in which movements are attracted toward the focus of attention. On the other hand, the possibility that this interpretation might not be fully exhaustive and that different components of closing-in might exist will also be discussed. (PsycINFO Database Record

show abstract

Closing-in behaviour in fronto-temporal dementia

Cited by 20 publications

References 13 publications

Anatomical Correlates of the "Closing-In" Phenomenon

Anatomical Correlates of the "Closing-In" Phenomenon

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

A critical review of closing-in.

Contact Info

Product

Resources

About