Closomers

Jalisatgi, Satish S.

doi:10.1002/9781119275602.ch2.1

Cited by 2 publications

(1 citation statement)

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“…621 Closomer structures, which consist of a [B 12 ] 2− icosahedral borane core from which up to 12 radial arms carrying the desired functionalities radiate outward, were investigated with the objective of developing platforms for drug delivery that would combine targeting vectors (antibodies or peptides) with diagnostic and therapeutic agents. 622 To improve the delivery of boron, multifunctional dendrimers that could allow diagnosis via fluorescence and therapy by combining BNCT and photodynamics were synthesized for potential application to BNCT. These boronenriched dendrimers are constructed with a fluorescent core (aryl-ether or meso-porphyrin) with branches that end with 8, 9, 16, or 32 neutral carboranyl clusters (Figure 58) 623 or 6, 8, 9, or 12 anionic cobaltabisdicarbollide units (Figure 59).…”

Section: Boron Neutron Capture Therapy (Bnct)mentioning

confidence: 99%

The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

Grams,

Santos,

Scorei

et al. 2024

Chem. Rev.

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Boron-containing compounds (BCC) have emerged as important pharmacophores. To date, five BCC drugs (including boronic acids and boroles) have been approved by the FDA for the treatment of cancer, infections, and atopic dermatitis, while some natural BCC are included in dietary supplements. Boron's Lewis acidity facilitates a mechanism of action via formation of reversible covalent bonds within the active site of target proteins. Boron has also been employed in the development of fluorophores, such as BODIPY for imaging, and in carboranes that are potential neutron capture therapy agents as well as novel agents in diagnostics and therapy. The utility of natural and synthetic BCC has become multifaceted, and the breadth of their applications continues to expand. This review covers the many uses and targets of boron in medicinal chemistry.

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Section: Boron Neutron Capture Therapy (Bnct)mentioning

confidence: 99%