Clostridioides difficile infection: An emerging zoonotic disease

Abstract

Clostridioides difficile is a spore-forming enteric pathogen of public health concern causing a toxin-mediated diarrhea in humans. In several countries, the bacterium has evolved as a hypervirulent, antibiotic-resistant pathogen with concerns for its nosomial and communityassocaited routes for disease transmission. Although the exact routes for community-associated infection have not been substantially elucidated, recent surveillance and genetic diversity analysis of community-borne isolates indicate for the potential spillover of the pathogen amongst the human, animal and environment interfaces. This review article highlights the importance of One Health approach for the control of C. difficile infection.