Clostridium butyricum Ameliorates the Effect of Coprophagy Prevention on Hepatic Lipid Synthesis in Rabbits via the Gut–Liver Axis

Li, Zhichao; Chen, Mengjuan; Zhang, Ran; Wang, Zhitong; He, Hui; Wan, Zhiyi; Li, Hengjian; Cai, Hanfang; Chen, Zhi; Li, Ming; Xu, Huifen

doi:10.3390/ijms242417554

IJMS

2023

DOI: 10.3390/ijms242417554

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Clostridium butyricum Ameliorates the Effect of Coprophagy Prevention on Hepatic Lipid Synthesis in Rabbits via the Gut–Liver Axis

Zhichao Li,

Mengjuan Chen,

Ran Zhang

et al.

Abstract: Coprophagy prevention (CP) affects the growth performance, hepatic lipid synthesis, and gut microbiota in rabbits. Supplementation with Clostridium butyricum (C. butyricum, Strain number: CCTCC M 2019962) has been found to improve growth performance in rabbits. However, it remains unknown whether C. butyricum can ameliorate the effects of CP on hepatic lipid synthesis and the underlying mechanisms are yet to be elucidated. Therefore, this study aimed to investigate the impact of CP on hepatic lipid synthesis a… Show more

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Cited by 3 publications

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Clostridium butyricum, a future star in sepsis treatment

Zhao,

Jiang,

et al. 2024

Front. Cell. Infect. Microbiol.

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Sepsis is a systemic inflammatory response syndrome of multiorgan failure caused by dysregulation of the host response to infection and is a major cause of death in critically ill patients. In recent years, with the continuous development of sequencing technology, the intestinal microecology of this disease has been increasingly studied. The gut microbiota plays a host-protective role mainly through the maintenance of normal immune function and the intestinal barrier. Recent evidence suggests that intestinal flora dysbiosis plays a crucial role in sepsis. Clostridium butyricum (C. butyricum), which has been used as a probiotic in poultry feed since its discovery, has been found to play a potential protective role in intestinal infections, inflammatory bowel disease (IBD), colorectal cancer, and other diseases in recent studies. In this review, we continue to focus on the important role and mechanism of C. butyricum as a probiotic in human diseases, especially intestinal diseases. Additionally, we evaluate the research progress of C. butyricum in treatment of sepsis to identify more therapeutic targets for the clinical treatment of sepsis.

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Clostridium butyricum, a future star in sepsis treatment

Zhao,

Jiang,

et al. 2024

Front. Cell. Infect. Microbiol.

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Interplay between Bile Acids and Intestinal Microbiota: Regulatory Mechanisms and Therapeutic Potential for Infections

Li,

Chen,

Tang

2024

Pathogens

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Bile acids (BAs) play a crucial role in the human body’s defense against infections caused by bacteria, fungi, and viruses. BAs counteract infections not only through interactions with intestinal bacteria exhibiting bile salt hydrolase (BSH) activity but they also directly combat infections. Building upon our research group’s previous discoveries highlighting the role of BAs in combating infections, we have initiated an in-depth investigation into the interactions between BAs and intestinal microbiota. Leveraging the existing literature, we offer a comprehensive analysis of the relationships between BAs and 16 key microbiota. This investigation encompasses bacteria (e.g., Clostridioides difficile (C. difficile), Staphylococcus aureus (S. aureus), Escherichia coli, Enterococcus, Pseudomonas aeruginosa, Mycobacterium tuberculosis (M. tuberculosis), Bacteroides, Clostridium scindens (C. scindens), Streptococcus thermophilus, Clostridium butyricum (C. butyricum), and lactic acid bacteria), fungi (e.g., Candida albicans (C. albicans) and Saccharomyces boulardii), and viruses (e.g., coronavirus SARS-CoV-2, influenza virus, and norovirus). Our research found that Bacteroides, C. scindens, Streptococcus thermophilus, Saccharomyces boulardii, C. butyricum, and lactic acid bacteria can regulate the metabolism and function of BSHs and 7α-dehydroxylase. BSHs and 7α-dehydroxylase play crucial roles in the conversion of primary bile acid (PBA) to secondary bile acid (SBA). It is important to note that PBAs generally promote infections, while SBAs often exhibit distinct anti-infection roles. In the antimicrobial action of BAs, SBAs demonstrate antagonistic properties against a wide range of microbiota, with the exception of norovirus. Given the intricate interplay between BAs and intestinal microbiota, and their regulatory effects on infections, we assert that BAs hold significant potential as a novel approach for preventing and treating microbial infections.

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Determination of the effect of the enzyme and probiotic complex on animal productivity

Shkromada,

Suprun,

Fotin

et al. 2024

Scientific Horizons

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During weaning, rabbits experience production and feed stress, which results in a decrease in body resistance. Young animals in the transition period often have gastrointestinal disorders and significant weight loss. Probiotic strains of microorganisms and enzymes are a safe alternative for stimulating growth and supporting rabbit immunity. The purpose of the study was to determine the effect of additives to the basic diet on the haematological status, biochemical and productive parameters of rabbits. Methods used: zootechnical, haematological, biochemical, statistical. In the experimental groups where enzymes with probiotics were used, an increase in live weight was observed on the 30th day of the experiment: in the first experimental group by 4.18%, in the second – by 9.69%, in the third – by 18.72%. At the time of reaching the slaughter age, the live weight of rabbits increased by 5.47%, in the second by 11.0%, and in the third by 12.6%. The average daily increase in the groups where the complex supplement was used was higher, respectively, by: 6.64%; 12.58%, 32.86%. During the entire period of the experiment, gastrointestinal diseases were observed in three control rabbits that received treatment. Feed conversion was better in the first experimental group by 90.73 %, in the second – by 76.58 %, in the third – by 82.92%, compared to the control. In the group where three probiotic strains were used, an increase in red blood cells by 68.19% (P<0.05), haemoglobin by 28.44%, and white blood cells by 72.17% was recorded. In rabbits of the experimental groups, lipid metabolism improved against the background of cholesterol reduction in the first by 25.3%, the second – by 36.6%, and the third – by 39.4%. Protein and albumin absorption increased in the experimental groups: in the first by 15.33%, in the second – by 24.04%, in the third – by 28.57%. Mineral metabolism improved in animals of the experimental groups due to an increase in the calcium content in the first by 10.1%, the second – by 8.7%, and the third – by 17.9%. The practical significance of this study is to increase productivity and reduce gastrointestinal disorders by applying enzymes and probiotic strains of bacteria to the main diet

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Clostridium butyricum Ameliorates the Effect of Coprophagy Prevention on Hepatic Lipid Synthesis in Rabbits via the Gut–Liver Axis

Cited by 3 publications

References 34 publications

Clostridium butyricum, a future star in sepsis treatment

Clostridium butyricum, a future star in sepsis treatment

Interplay between Bile Acids and Intestinal Microbiota: Regulatory Mechanisms and Therapeutic Potential for Infections

Determination of the effect of the enzyme and probiotic complex on animal productivity

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