Clostridium butyricum and Chitooligosaccharides in Synbiotic Combination Ameliorate Symptoms in a DSS-Induced Ulcerative Colitis Mouse Model by Modulating Gut Microbiota and Enhancing Intestinal Barrier Function

Abstract

Ulcerative colitis (UC), an idiopathic intestinal disease characterized by continuous remission/relapse inflammatory cycles in the colonic mucosal layer, has strong adverse effects on patients’ quality of life and considerable costs for health care systems. Probiotics, prebiotics, and synbiotics are regarded as potential therapeutic agents for UC, in terms of safety and efficacy.

Administering Lactiplantibacillus fermentum F6 decreases intestinal Akkermansia muciniphila in a dextran sulfate sodium-induced rat colitis model

“…For example, when analyzed using multivariate analysis methods like principal coordinate analysis, experimental colitis mice induced by 2.5% or 5% DSS showed a distinct difference in the gut microbiota structure from healthy mice, and a lower alpha diversity (assessed by Chao 1, Ace, Shannon, and Simpson indices) was noted in diseased mice compared with the healthy ones. 14,40 Similar outcomes were also observed in a rat model of UC induced by 4% DSS supplement. 41 The common features between these studies are that DSS induction resulted in significantly reduced microbial community richness and evenness and altered gut microbiota structure.…”

“…alpha diversity (assessed by Chao 1, Ace, Shannon, and Simpson indices) was noted in diseased mice compared with the healthy ones. 14,40 Similar outcomes were also observed in a rat model of UC induced by 4% DSS supplement. 41 The common features between these studies are that DSS induction resulted in significantly reduced microbial community richness and evenness and altered gut microbiota structure.…”

“…Akkermansia muciniphila (A. muciniphila) is a mucin-degrading bacterium that has often been detected in the gut of humans and animals with UC. 12 Some studies have reported a reduction in the abundance of A. muciniphila, [13][14][15][16] while others have observed the opposite trend, [17][18][19][20][21][22][23] suggesting a potential negative or positive correlation with UC. More importantly, these correlations have been further confirmed by some interventional studies showing that the consumption of A. muciniphila can alleviate 24,25 or aggravate [26][27][28] disease process, indicating that it has a dichotomous role in UC.…”

Effects of chitooligosaccharide on the in vitro antibacterial activity against avian Escherichia coli and the pharmacokinetics of florfenicol in healthy chickens

“…Specifically, COS has been reported to promote the growth of certain beneficial gut microbiota. We speculate that changes in gut microbiota may be one of the reasons for alterations in the metabolism of florfenicol ( Huang et al., 2023 ). Similar effects have also been reported in a previous study ( Elgeddawy et al., 2020 ).…”

Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment

“…The intricate relationship between gut microbiota and intestinal barrier function is pivotal, where probiotics can mitigate epithelial damage and regulate inflammatory responses. The combination of Faecalibacterium prausnitzii , a butyrate-producing bacterium, with chitosan oligosaccharides, can restore tight junction levels and enhance intestinal epithelial barrier function ( 82 ). Supplementation with prebiotics, probiotics, IgG, and amino acids collectively improves IBD intestinal barrier function ( 83 ).…”