Clostridium difficile infection in a patient with Crohn disease

Abstract

Crohn disease is a chronic inflammatory disorder, which is rare in pediatric patients. The definite etiology and mechanism to induce an acute exacerbation of Crohn disease remains mostly unknown. The authors report on a 14-year-old girl with Crohn disease who has acute gastrointestinal symptoms caused by toxin A-producing Clostridium difficile, which mimicked a flare-up of Crohn disease. There was no preceding antibiotic prescription before the episode. The disease activity did not improve after steroid treatment, which is unusual for Crohn disease. However, all symptoms were dramatically relieved after eradication of C difficile, and led to a symptom-free period for more than 3 years. This case report aims to address the unusual presentation of a usual pathogen, C difficile, in a pediatric patient with Crohn disease.

The impact of Clostridum difficile on surgical rate among ulcerative colitis patients: A systemic review and meta-analysis

“…Subsequently, 19 articles[ 5 8 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 ] did not meet the inclusion criteria. The reasons for exclusion included the following: five articles[ 16 20 24 25 26 ] were review, four studies[ 17 22 29 31 ] focused on children, six studies[ 18 21 23 27 28 30 ] did not report the outcome of interest, one article[ 19 ] was case report, and three studies[ 5 32 33 ] did not give complete data. Therefore, five studies[ 9 10 11 12 36 ] with 2380 patients fulfilled the inclusion criteria [ Figure 1 ].…”

Pseudomembranous colitis complicating the natural course of Crohn´s disease in a pediatric patient

“…The differential diagnosis between the two diseases is often difficult, as the symptoms are similar and C.difficile may precipitate a flare up of the inflammatory pathology [29]. In the case of children very little is known about the association between the two pathologies, as it is rarely described in the academic literature [29].…”

“…The differential diagnosis between the two diseases is often difficult, as the symptoms are similar and C.difficile may precipitate a flare up of the inflammatory pathology [29]. In the case of children very little is known about the association between the two pathologies, as it is rarely described in the academic literature [29]. Nonetheless, it seems that the acute aspect of Crohn's disease can not controlled in the absence of an appropriate treatment for the C.difficile infection, and the specific treatment for Crohn's disease (corticotherapy) should be continued with much lower doses in order to decrease the necessity of performing surgery [29].…”

Impact of Mycobacterium Avium subspecies Paratuberculosis (MAP) on Crhon’s disease and Effective Nursing Care

“…However, given the possibility that MAP bacteria can be infected through cattle and pig feces, it can be inferred from previous studies that if the chickens is close to beef or pork livestock and if the chicken that eats insects that live on the land where cow and pig feces exist, it is also likely to be exposed to MAP bacteria (University of Wisconsin -Madison/ School of Veterinary Medicine; Crohn's MAP Vaccine). The exacerbation of Crohn's disease symptoms due to C. difficile infection, commonly known as the most common cause of food poisoning, has been found in many studies (Binion, (Binion, 2012;Hsu et al, 2012;Nitzan et al, 2013;Zhang et al, 2016). Therefore, it is best to avoid spoiled food in terms of food intake (Nitzan et al, 2013;Zhang et al, 2016).…”