Clostridium difficile Infection Rates During the Pandemic in New York Capital Area: A Single-Center Study

Zouridis, Spyridon; Sangha, Maheep; Feustel, Paul J.; Richter, Seth

doi:10.7759/cureus.37576

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…If in 2016 the number of cases was 1.73‰, it progressively increased to 9.81‰ in 2017, 14.36‰ in 2019, 16‰ in 2020, reaching the highest incidence of 22.02‰ in 2021, followed by a slight decline to 17.21‰ in 2022, and then 16.7‰. An increase in CDI incidence is reported in other studies, explaining that this rise is because of increased use of antibiotics and/or steroids, or even the modification of the patient population profile admitted during the pandemic [18,[27][28][29]. In another study, Markovic-Denic L reported that the incidence density rate was three times higher when the hospital was a dedicated COVID-19 hospital, meaning only COVID-19-positive patients were admitted, compared to the period when it was a non-COVID-19 hospital, before and during the COVID-19 pandemic [30].…”

Section: Discussionmentioning

confidence: 69%

COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit

Stoian,

Andone,

Boeriu

et al. 2024

Antibiotics

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Since the emergence of SARS-CoV-2 in late 2019, the global mortality attributable to COVID-19 has reached 6,972,152 deaths according to the World Health Organization (WHO). The association between coinfection with Clostridioides difficile (CDI) and SARS-CoV-2 has limited data in the literature. This retrospective study, conducted at Mureș County Clinical Hospital in Romania, involved 3002 ICU patients. Following stringent inclusion and exclusion criteria, 63 patients were enrolled, with a division into two subgroups—SARS-CoV-2 + CDI patients and CDI patients. Throughout their hospitalization, the patients were closely monitored. Analysis revealed no significant correlation between comorbidities and invasive mechanical ventilation (IMV) or non-invasive mechanical ventilation (NIMV). However, statistically significant associations were noted between renal and hepatic comorbidties (p = 0.009), death and CDI-SARS-CoV-2 coinfection (p = 0.09), flourochinolone treatment and CDI-SARS-CoV-2 infection (p = 0.03), and an association between diabetes mellitus and SARS-CoV-2-CDI infection (p = 0.04), as well as the need for invasive mechanical ventilation (p = 0.04). The patients with CDI treatment were significantly younger and received immuno-modulator or corticotherapy treatment, which was a risk factor for opportunistic agents. Antibiotic and PPI (proton pump inhibitor) treatment were significant risk factors for CDI coinfection, as well as for death, with PPI treatment in combination with antibiotic treatment being a more significant risk factor.

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Section: Discussionmentioning

confidence: 69%

COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit

Stoian,

Andone,

Boeriu

et al. 2024

Antibiotics

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“…In line with our findings, a recently published paper indicated a trend similar to that of Clostridium difficile infections over a 5-year period (2018-2021). It revealed that the infection incidence rate increased from 5.67 +/− 0.35 before the onset of the pandemic to 8.06 +/− 0.41 in the 2020-2021 period (95% confidence interval) [18].…”

Section: Discussionmentioning

confidence: 99%

Evaluating Healthcare-Associated Infections in Public Hospitals: A Cross-Sectional Study

Iancu,

Moldovan,

Țilea

et al. 2023

Antibiotics

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Background: Hospital-acquired infections (HAIs) pose a significant danger to global public health, mainly because their numbers are growing exponentially each year. Additionally, the rise of bacterial strains resistant to current treatment options further exacerbates this threat. This study aimed to examine the occurrences of HAIs identified in public hospitals at the county level. Methods: We conducted a cross-sectional study utilizing data provided to the Mures Public Health Directorate from all the public hospitals within the studied county. We examined HAIs reported during the period spanning from 2017 to 2021, which amounted to a total of 4603 cases. Results: The medical departments reported the highest prevalence of HAIs at 48.25%. The most common infections included enterocolitis with Clostridioides difficile (32.61%), COVID-19 (19.83%), bronchopneumonia (16.90%), sepsis, surgical wound infections, and urinary tract infections. The five most frequently identified pathogens were Clostridioides difficile (32.61%), SARS-CoV-2 (19.83%), Acinetobacter baumannii (11.82%), Klebsiella pneumoniae (9.58%), and Pseudomonas aeruginosa (7.95%). Acinetobacter baumannii was the predominant agent causing bronchopneumonia, while Klebsiella pneumoniae was the leading cause of sepsis cases. Escherichia coli was the primary agent behind the urinary tract infections, and Staphylococcus aureus MRSA was identified as the main etiology for wound infections and central catheter infections. Throughout the study period, there was a significant rise in Clostridioides difficile and Gram-negative bacteria prevalence rates. Conclusions: This study identified increased Clostridioides difficile in HAI cases during COVID-19, highlighting the need for careful antibiotic use and emphasizing the growing challenge of multi-resistant strains in post-pandemic state hospitals.

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Clostridioides difficile infections caused by hypervirulent strains: a single-centre real-life study

Tiecco,

De Francesco,

Lenzi

et al. 2024

Eur J Clin Microbiol Infect Dis

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Clostridium difficile Infection Rates During the Pandemic in New York Capital Area: A Single-Center Study

Cited by 4 publications

References 22 publications

COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit

COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit

Evaluating Healthcare-Associated Infections in Public Hospitals: A Cross-Sectional Study

Clostridioides difficile infections caused by hypervirulent strains: a single-centre real-life study

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