Clostridium paraputrificum: An atypical and rare case of septic arthritis mimicking an acute sickle cell crisis

Ciuro, Jordan; Little, Tania; Hiner, Evan; Vakhariya, Cynthia

doi:10.1016/j.idcr.2020.e01031

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…When evidence of a septic or osteomyelytic joint is evident, empiric treatment with broad-spectrum antibiotics can result in a reduction in the overall incidence of infected joints [ 5 ]. However, empiric treatment of patients with vaso-occlusive symptoms also suggestive of an infected joint can lead to antibiotic resistance and increased costs for the patients [ 6 ]. Due to the dearth of unambiguous clinical evidence available to a hospitalist physician to distinguish between a VOC and an intraarticular infection at initial presentation, the subjective descriptions of patients with sickle cell disease are important pieces of diagnostic information.…”

Section: Discussionmentioning

confidence: 99%

Probing Beyond the Pain Scale: A Rare Case of Cutibacterium Acnes Septic Arthritis

Keys¹,

Ishac²,

Cuellar³

et al. 2022

Cureus

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Patients with sickle cell disease frequently present to the hospital for pain control secondary to vasoocclusive crises (VOCs). Diagnostic challenges exist for healthcare providers in distinguishing joint pain secondary to a VOC from an intraarticular infection at initial presentation due to the lack of established clinical markers exclusive to one or the other. We present a 35-year-old female with sickle cell disease and avascular necrosis of bilateral hips and the right shoulder with several previous admissions for VOC pain control complaining of a "different" kind of pain in her shoulder. Treated initially for pain control, our patient was found to be suffering from culture-positive septic arthritis of the shoulder with Cutibacterium acnes, a rare source of de novo intraarticular infection. This case highlights the importance of incorporating patients' subjective descriptions of illness into differential diagnosis considerations, notably for those caring for patients with sickle cell disease. This case also establishes C. acnes as a rare organism responsible for de novo septic arthritis in the setting of sickle cell disease.

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Section: Discussionmentioning

confidence: 99%

Probing Beyond the Pain Scale: A Rare Case of Cutibacterium Acnes Septic Arthritis

Keys¹,

Ishac²,

Cuellar³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…C. paraputrificum infections have manifest as bacteremia and sepsis [1] , [2] , [3] , septic arthritis [4] , [5] , osteomyelitis [5] , pyogenic liver abscess [6] , aspiration pneumonia [7] , acute necrotizing enterocolitis [8] , and colonic necrosis [9] . Identified risk factors are like those associated with Clostridium infections in the general population; these include sickle cell anemia [2] , [4] , gastrointestinal pathology [3] , human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) [3] , [9] , neutropenia [8] , malignancy [10] , and diabetes mellitus [11] . However, there have been cases in which C. paraputrificum manifest in a patient without any known risk factors aside from advanced age [7] , [9] .…”

Section: Introductionmentioning

confidence: 99%

Clostridium paraputrificum bacteremia in a patient with presumptive complicated appendicitis: A case report

Mostel

Hernandez

Tatem

2022

IDCases

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Here we present a rare case of Clostridium paraputrificum bacteremia in the setting of presumptive complicated appendicitis. The patient was an elderly male who presented in respiratory failure secondary to a suspected aspiration pneumonia. A blood culture result for C. paraputrificum guided the investigation toward an abdominal source of infection as this uncommon isolate has been reported as a gastrointestinal species. He was treated with ampicillin-sulbactam while in the hospital and discharged with metronidazole along with a planned appendectomy as an outpatient. There is no tissue histopathology to date to confirm the presumptive likely diagnosis of complicated appendicitis found on abdominal imaging.

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Clostridium paraputrificum Bacteremia in a Patient with Human Immunodeficiency Virus Infection: A Case Report and Literature Review

Hosin¹,

Abu-Ali²,

Rashed³

et al. 2023

IDR

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Clostridium paraputrificum (C. paraputrificum) is clinically important due to its association with underlying medical conditions. Infection with C. paraputrificum may worsen HIV prognosis, leading to acquired immunodeficiency syndrome. However, it is not frequently isolated and its susceptibility to antibiotics has not been well studied. Our report examines the case of a patient with human immunodeficiency virus (HIV) infection, who was diagnosed with Clostridium paraputrificum bacteremia. A 59-year-old male was admitted to hospital with a medical history of human immunodeficiency virus (HIV), hepatitis C virus (HCV), and neck pain. Following episodes of high fever, the patient received a full work up to test for sepsis. Blood culture revealed bacterial growth, and MALDI-TOF mass spectrometry confirmed the diagnosis of Clostridium paraputrificum bacteremia. The patient received treatment with meropenem and vancomycin antibiotics, which cleared the infection after 48 hours; however, inflammatory markers remained high. To date, a limited number of reported cases of C. paraputrificum exist; thus, this case report contributes valuable information to the literature to improve our understanding of its action and resistance profiles and aid future bacteremia management.

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Clostridium paraputrificum: An atypical and rare case of septic arthritis mimicking an acute sickle cell crisis

Cited by 3 publications

References 9 publications

Probing Beyond the Pain Scale: A Rare Case of Cutibacterium Acnes Septic Arthritis

Probing Beyond the Pain Scale: A Rare Case of Cutibacterium Acnes Septic Arthritis

Clostridium paraputrificum bacteremia in a patient with presumptive complicated appendicitis: A case report

Clostridium paraputrificum Bacteremia in a Patient with Human Immunodeficiency Virus Infection: A Case Report and Literature Review

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