Clostridium perfringens - A bacterial pathogen gaining recognition in necrotizing pancreatitis

Biswas, Rakhi; Deepika, Keerti; Sistla, Sujatha; Sistla, Sarath Chandra; Anandhi, Amaranathan

doi:10.1016/j.anaerobe.2017.05.006

Cited by 9 publications

(8 citation statements)

References 11 publications

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“…The way in which C. perfringens infects pancreatic tissue is not well known. It is supposed that it reaches the gland either by retrograde duodenal infection, migration through the biliary tree, or by bacterial mural translocation from the colon due to increasing permeability of the colonic serosa in the context of inflamed pancreas tissue [8,[11][12][13][14]. However, spontaneous clostridial necrotic infection of the pancreas in the absence of enteric fistula or history of endoscopic or surgical procedures is extremely rare [8].…”

Section: Discussionmentioning

confidence: 99%

Clostridium perfringens necrotizing pancreatitis: an unusual pathogen in pancreatic necrosis infection

Sánchez-Gollarte

Jiménez‐Alvárez

Pérez-González

et al. 2021

Access Microbiology

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Pancreatic necrosis infection (PNI) accounts for about 20–40 % of severe acute pancreatitis. PNI caused by anaerobic bacteria is unusual but when they present, Clostridium perfringens is the microorganism most commonly involved. We present a 60-year-old patient with a previous history of SARS-CoV-2, diagnosed with acute pancreatitis. During the hospitalisation he developed Clostridium perfringens bacteraemia. A CT-scan showed pancreatic gas gangrene and a surgical necrosectomy was performed. Clostridium perfringens was isolated in cultures of the pancreatic tissue and collections. The patient’s clinical status improved after surgery and the appropriate medical therapy. He was discharged 76 days after admission. Nowadays, the ‘step-up approach’ is an accepted therapeutic tool in treatment of pancreatic necrosis and peripancreatic fluid collections. However, most authors suggest that Clostridum perfringens infection requires a more aggressive approach due to the high mortality associated to clostridial infection.

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Section: Discussionmentioning

confidence: 99%

Clostridium perfringens necrotizing pancreatitis: an unusual pathogen in pancreatic necrosis infection

Sánchez-Gollarte

Jiménez‐Alvárez

Pérez-González

et al. 2021

Access Microbiology

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“…In previous publications describing acute pancreatitis in horses, an aetiologic agent was not identified. Clostridium perfringens has recently been associated with acute necrotising pancreatitis in humans and is now considered an important pathogen in this disease (Castro et al 2017;Biswas et al 2017). In humans, the most common type of C. perfringens identified is Type A (Holdsworth and Parratt 1996).…”

Section: Discussionmentioning

confidence: 99%

“…2017; Biswas et al . 2017). In humans, the most common type of C. perfringens identified is Type A (Holdsworth and Parratt 1996).…”

Section: Discussionmentioning

confidence: 99%

“…This alpha toxin, Phospholipase C produced by Type A, is considered especially important in disease progression due to its ability to cause massive haemolysis and necrosis (Holdsworth and Parratt 1996; Biswas et al . 2017). The culture of C. perfringens in this case suggests that this is the aetiologic agent; however, this should be interpreted with caution, as causation cannot be determined post‐mortem.…”

Section: Discussionmentioning

confidence: 99%

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Clinical pathology and ultrasonographic findings from a Warmblood gelding with primary, severe, acute pancreatitis

Lack

Crabtree

Won

et al. 2020

Equine Veterinary Education

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A 24-year-old Warmblood gelding presented with a 6-hour history of recurrent colic signs of increasing severity. Upon presentation, he was mildly painful, tachycardic and tachypnoeic and had decreased borborygmi. Nasogastric intubation resulted in no net reflux and rectal palpation revealed an ascending colon impaction. Percutaneous abdominal ultrasonography revealed dilated, thickened and hypomotile loops of small intestine. Complete blood count revealed leucopenia with neutropenia and an increased packed cell volume. Serum biochemistry revealed hyperproteinaemia, hyperglycaemia, hypocalcaemia, hyperbilirubinaemia, hypercholesterolaemia and elevated liver enzymes. Despite sedation and fluid resuscitation, the gelding became severely colicky. A repeat ultrasound was performed, revealing a moderate amount of free fluid and a mass effect between the liver and right dorsal colon. Abdominocentesis yielded a yellow, turbid fluid containing free-floating white debris with an increased total protein and lactate concentration. Cytology of the fluid revealed necrotic mesothelial cells. The gelding was humanely euthanised due to poor prognosis. Necropsy revealed acute, severe pancreatitis and duodenitis. The mass effect on ultrasonography was retrospectively identified as the pancreas exhibiting a similar architecture to that seen in cases of acute pancreatitis in small animals.

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“…C. perfringens type 'A' causes food poisoning and gas gangrene in humans. In a recent report, C. perfringens is found with the necrotic pancreatitis in the human beings [8] . Type 'D' is associated with 'pulpy kidney disease' and dysentery in sheep, while, type 'C' causes necrotic enteritis in animals and a condition named as struck [3,4] .…”

Section: Introductionmentioning

confidence: 92%

Pakistan’da İshalli Keçilerde Clostridium perfringens Toksinlerinin (α, β, ε, ι) Moleküler Tiplendirilmesi ve Tip ‘A’ Çoklu İlaç Direnç Profili

Hussain¹,

Ijaz²,

Durrani³

et al. 2017

Kafkas Univ Vet Fak Derg

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Clostridium perfringens - A bacterial pathogen gaining recognition in necrotizing pancreatitis

Cited by 9 publications

References 11 publications

Clostridium perfringens necrotizing pancreatitis: an unusual pathogen in pancreatic necrosis infection

Clostridium perfringens necrotizing pancreatitis: an unusual pathogen in pancreatic necrosis infection

Clinical pathology and ultrasonographic findings from a Warmblood gelding with primary, severe, acute pancreatitis

Pakistan’da İshalli Keçilerde Clostridium perfringens Toksinlerinin (α, β, ε, ι) Moleküler Tiplendirilmesi ve Tip ‘A’ Çoklu İlaç Direnç Profili

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