Clostridium perfringens strains proliferate to high counts in the broiler small intestinal tract, in accordance with necrotic lesion severity, and sporulate in the distal intestine

Hustá, Martina; Tretiak, Svitlana; Ducatelle, Richard; Immerseel, Filip Van; Goossens, Evy

doi:10.1016/j.vetmic.2023.109705

Cited by 2 publications

(4 citation statements)

References 19 publications

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“…Normal intestinal permeability prevents water and electrolyte loss, promotes the absorption of dietary nutrients, and prevents the entry of antigens and micro-organisms into the body, which are dependent on the integrity of the intestinal villi [31]. In a previous study, necrotic enteritis caused by C. perfringens was mostly observed in the jejunum, manifesting as intestinal morphological damage and inflammation [9]. In addition, SCFA can improve the proliferation of gut epithelial cells and increase their villi height, which subsequently helps to improve the capacity of the intestine for nutrient absorption [32].…”

Section: Discussionmentioning

confidence: 97%

“…As one of the most economically important diseases affecting poultry worldwide, necrotic enteritis causes $6 billion in annual losses globally [8]. In animals, associated lesions caused by C. perfringens have been found in the whole intestine, and were significantly more severe in the jejunum compared to the duodenum and ileum [9]. In healthy chickens, it is hard to find C. perfringens spores in the gastrointestinal tract, but the total number of vegetative C. perfringens cells increased when necrotic enteritis occurred, presenting a positive correlation between presence in the duodenum, jejunum, and ileum and disease severity [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…In animals, associated lesions caused by C. perfringens have been found in the whole intestine, and were significantly more severe in the jejunum compared to the duodenum and ileum [9]. In healthy chickens, it is hard to find C. perfringens spores in the gastrointestinal tract, but the total number of vegetative C. perfringens cells increased when necrotic enteritis occurred, presenting a positive correlation between presence in the duodenum, jejunum, and ileum and disease severity [9,10]. In a retrospective study, C. perfringens was also found to cause liver morphological lesions, necrotizing hepatitis, congested lungs, and neurological diseases, manifesting as tremors, stargazing, and incoordination [11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Microencapsulated Sodium Butyrate Alleviates Immune Injury and Intestinal Problems Caused by Clostridium Perfringens through Gut Microbiota

Yang,

Sun,

Dai

et al. 2023

Animals

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Microencapsulated sodium butyrate (MS-SB) is an effective sodium butyrate additive which can reduce the release of sodium butyrate (SB) in the fore gastrointestinal tract. In this study, we assess the protective effects and mechanisms of MS-SB in Clostridium perfringens (C. perfringens)-challenged broilers. Broiler chickens were pre-treated with SB or MS-SB for 56 days and then challenged with C. perfringens three times. Our results indicate that the addition of MS-SB or SB before C. perfringens infection significantly decreased the thymus index (p < 0.05). Serum IgA, IgY, and IgM concentrations were significantly increased (p < 0.05), while pro-inflammatory IL-1β, IL-6, and TNF-α were significantly decreased (p < 0.05) under MS-SB or SB supplementation. Compared with SB, MS-SB presented a stronger performance, with higher IgA content, as well as a lower IL-1β level when normal or C. perfringens-challenged. While C. perfringens challenge significantly decreased the villus height (p < 0.05), MS-SB or SB administration significantly increased the villus height and villus height/crypt depth (V/C ratio) (p < 0.05). Varying degrees of SB or MS-SB increased the concentrations of volatile fatty acids (VFAs) during C. perfringens challenge, where MS-SB presented a stronger performance, as evidenced by the higher content of isovaleric acid and valeric acid. Microbial analysis demonstrated that both SB or MS-SB addition and C. perfringens infection increase variation in the microbiota community. The results also indicate that the proportions of Bacteroides, Faecalibacterium, Clostridia, Ruminococcaceae, Alistipes, and Clostridia were significantly higher in the MS-SB addition group while, at same time, C. perfringens infection increased the abundance of Bacteroides and Alistipes. In summary, dietary supplementation with SB or MS-SB improves the immune status and morphology of intestinal villi, increases the production of VFAs, and modulates cecal microbiota in chickens challenged with C. perfringens. Moreover, MS-SB was more effective than SB with the same supplemental amount.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Microencapsulated Sodium Butyrate Alleviates Immune Injury and Intestinal Problems Caused by Clostridium Perfringens through Gut Microbiota

Yang,

Sun,

Dai

et al. 2023

Animals

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“…Acute enteritis is a prevalent intestinal disease in the broiler chicken sector of the poultry farming industry [5,6]. This disease damages the intestines of chickens, affecting food digestion, absorption, and the normal functioning of the immune system [7]. The prolonged growth period of Wenchang chickens exposes them to an increased susceptibility to acute enteritis [8].…”

Section: Introductionmentioning

confidence: 99%

Lactiplantibacillus plantarum and Saccharomyces cerevisiae—Fermented Coconut Water Alleviates Dextran Sodium Sulfate-Induced Enteritis in Wenchang Chicken: A Gut Microbiota and Metabolomic Approach

Zheng,

Han,

Zhang

et al. 2024

Animals

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In order to investigate the potential mechanisms of probiotic-fermented coconut water in treating enteritis, this study conducted a comprehensive analysis of the effects of probiotic intervention on the recovery from Dextran Sodium Sulfate-induced acute enteritis in Wenchang chicks. The analysis encompassed the assessment of growth performance, serum indicators, intestinal tissue structure, and metagenomic and metabolomic profiles of cecal contents in 60 Wenchang chicks subjected to intervention. This approach aimed to elucidate the impact of probiotic intervention on the recovery process from acute enteritis at both the genetic and metabolic levels in the avian model. The results revealed that intervention with Saccharomyces cerevisiae Y301 improved the growth rate of chicks. and intervention with Lactiplantibacillus plantarum MS2c regulated the glycerophospholipid metabolism pathway and reshaped the gut microbiota structure in modeling chicks with acute enteritis, reducing the abundance of potentially pathogenic bacteria from the Alistipes and increasing the abundance of potentially beneficial species from the Christensenellaceae. This intervention resulted in the production of specific gut metabolites, including Gentamicin C and polymyxin B2, recognized for their therapeutic effects on acute enteritis. The combined intervention of S. cerevisiae Y301 and L. plantarum MS2c not only enhanced growth performance but also mitigated intestinal wall damage and increased the abundance of gut metabolites such as gentamicin C and polymyxin B2, thereby mitigating symptoms of enteritis. Furthermore, this combined intervention reduced the levels of serum immune markers, including IL-10, IL-6, TNF-α, IFN-γ, and D-lactic acid, thus mitigating intestinal epithelial cell damage and promoting acute enteritis recovery. This study provides crucial insights into the mechanisms of action of probiotics and probiotic-fermented coconut water in acute enteritis recovery, offering new perspectives for sustainable farming practices for Wenchang chicken.

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Clostridium perfringens strains proliferate to high counts in the broiler small intestinal tract, in accordance with necrotic lesion severity, and sporulate in the distal intestine

Cited by 2 publications

References 19 publications

Microencapsulated Sodium Butyrate Alleviates Immune Injury and Intestinal Problems Caused by Clostridium Perfringens through Gut Microbiota

Microencapsulated Sodium Butyrate Alleviates Immune Injury and Intestinal Problems Caused by Clostridium Perfringens through Gut Microbiota

Lactiplantibacillus plantarum and Saccharomyces cerevisiae—Fermented Coconut Water Alleviates Dextran Sodium Sulfate-Induced Enteritis in Wenchang Chicken: A Gut Microbiota and Metabolomic Approach

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