Clostridium scindens metabolites trigger prostate cancer progression through androgen receptor signaling

Bui, Ngoc-Niem; Li, Chen-Yi; Ly, Wang; Chen, Yuan; Kao, Wei-Hsiang; Chou, Li‐Fang; Hsieh, Jer‐Tsong; H, Lin; Lai, Chih‐Ho

doi:10.1016/j.jmii.2022.12.009

Cited by 10 publications

(1 citation statement)

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“…Clostridium scindens is a member of the gut microbiota that converts cortisol into 11β-hydroxyl androstenedione, a potent androgen precursor. Cortisol metabolites derived from Clostridium s cindens -conditioned medium promote the proliferation and migration of androgen-dependent PCa cells, which indicate that Clostridium scindens promotes PCa progression by activating androgen receptor signaling [ 84 ].…”

Section: Gut Microbiota Play a Role In The Development And Progressio...mentioning

confidence: 99%

Potential effects of gut microbiota on host cancers: focus on immunity, DNA damage, cellular pathways, and anticancer therapy

Sun

Feng

2023

The ISME Journal

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The symbiotic bacteria that live in the human gut and the metabolites they produce have long influenced local and systemic physiological and pathological processes of the host. The gut microbiota are increasingly being recognized for its impact on a range of human diseases, including cancer, it may play a key role in the occurrence, progression, treatment, and prognosis of many types of cancer. Understanding the functional role of the gut microbiota in cancer is crucial for the development of the era of personalized medicine. Here, we review recent advances in research and summarize the important associations and clear experimental evidence for the role of the gut microbiota in a variety of human cancers, focus on the application and possible challenges associated with the gut microbiota in antitumor therapy. In conclusion, our research demonstrated the multifaceted mechanisms of gut microbiota affecting human cancer and provides directions and ideas for future clinical research.

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Section: Gut Microbiota Play a Role In The Development And Progressio...mentioning

confidence: 99%