Clostridium Sordelli Infection

Browdie, David A.; Davis, John H.; Koplewitz, Martin J.; Corday, Lucien; Leadbetter, Allen W.

doi:10.1097/00005373-197506000-00011

Cited by 20 publications

(15 citation statements)

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“…sordellii usually associated with other Clostridium spp. has been shown to be an unusual causative micro-organism of gas gangrene in man; it has rarely been found as the unique pathogen in that disease: in such cases, muscular lesions with gelatinous oedema without obvious necrosis have been described previously (MacLennan, 1962;Browdie et al, 1975).…”

Section: Discussionmentioning

confidence: 99%

Non-traumatic clostridial myositis: an unusual feature of brain death

Thys

Ectors

Noël

1980

Postgraduate Medical Journal

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Section: Discussionmentioning

confidence: 99%

Non-traumatic clostridial myositis: an unusual feature of brain death

Thys

Ectors

Noël

1980

Postgraduate Medical Journal

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“…Intra-muscular injection of a sublethal dose of TcsL into mice causes pronounced localized symptoms such as edema, inflammation, myofibril disassembly, and degeneration of skeletal muscle fibres within 24 h. The damage persists for 6 to 9 days and (slowly) regenerates over a period of 60 days [10]. Intradermal injection of TcsL into animals results in local necrosis, progressive edema due to local and systemic vascular permeability, and death [11,12]. The symptoms observed upon TcsL injection in mice resemble those occurring in C. sordellii infections in humans [3].…”

Section: The Biological Activity Of C Sordellii Toxins In Animal Modelsmentioning

confidence: 99%

Glucosylation of Rho/Ras Proteins by Lethal Toxin – Implications of Actin Re-Organization and Apoptosis in C. Sordellii-Associated Disease

Genth

Schulz²,

Just³

2013

TOTNJ

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Clostridium sordellii causes disease in livestock and life-threatening illnesses in humans. Pathogenic C. sordellii strains produce up to seven virulence factors, including lethal toxin (TcsL), hemorrhagic toxin, a hemolysin, a DNAse, a collagenase, and a lysolecithinase cell. TcsL exhibits an A-B toxin-like structure and enters its target cells by receptor-mediated endocytosis. Inside the, TcsL mono-glucosylates low molecular weight GTP-binding proteins of the Ras and Rho families. This article reviews recent progress for (i) re-enforcing (H/K/N)Ras glucosylation and subsequent inhibition of the phosphoinositide 3-kinase (PI3K) / Akt survival signalling pathway as the cause of TcsL-induced apoptotic cell death, and (ii) showing the critical nature of Rac1 glucosylation in the loss of epithelial and endothelial barrier function. Finally, the detection of TcsL-induced glucosylation of Rac1 and (H/K/N)Ras using glucosylationsensitive antibodies is presented as a new method to track TcsL activity.

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“…Recently, fatal human cases have been reported due to episiotomy, spontaneous endometritis with maternal death, and deep laceration of a thigh infection (13,31,44,78). …”

Section: Clostridium Chauvoei and Clostridium Septicummentioning

confidence: 99%

Clostridial toxins: potent poisons, potent medicines

Baldassi¹

2005

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:Clostridium is an anaerobic bacterial genus. The clostridia produce more protein toxins than any other bacterial genus and are a rich reservoir of toxins for research and medicinal uses. Clostridia are widely spread in the environment:soil, dust and water, presenting more than 120 described species, although few can cause diseases. Diseases can grossly be divided into neurotropic disorders (nervous system is primarily affected), enterotoxemias (affecting intestinal tract and parenchymatous organs), and gas gangrene (myonecrosis with toxemia).Undoubtedly the most widely recognized infection due to anaerobes was clostridial myonecrosis, but recently interest has arisen for the role of clostridia in intestinal diseases. This report describes the most important species, the diseases caused by them, and their occurrence in Brazil, focusing on cattle raising.

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Clostridium Sordelli Infection

Cited by 20 publications

References 0 publications

Non-traumatic clostridial myositis: an unusual feature of brain death

Non-traumatic clostridial myositis: an unusual feature of brain death

Glucosylation of Rho/Ras Proteins by Lethal Toxin – Implications of Actin Re-Organization and Apoptosis in C. Sordellii-Associated Disease

Clostridial toxins: potent poisons, potent medicines

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