Clostridium sporogenes bacteremia in an immunocompetent patient

Abstract

Of the 200 Clostridium spp. known to exist, approximately 30 have been associated with human disease. Commonly found in soil, marine sediment and mammalian intestinal tracts, these gram-positive bacilli are known to cause infections ranging from cellulitis to septicemia. Isolates that are identified by clinical microbiology laboratories include Clostridium perfrigens species in 20–40% of cases. However, when Clostridium sporogenes is identified, is rarely considered to be pathogenic. We present a case of Clostridium sporogenes bacteremia secondary to lower limb cellulitis and osteomyelitis in an immunocompetent patient.

Clostridium botulinum – like organism bacteremia in a user of black tar heroin

“…Similarly, non-toxigenic strains of C. botulinum have previously been described, though these are often classified as “ C. botulinum- like” as they do not produce neurotoxin [ 4 ]. Nontoxigenic C. botulinum- like organisms, such as Clostridium sporogenes , are rarely considered pathogenic, though a few cases of bacteremia, septicemia and soft-tissue infections have been described by these organisms in the past [ 5 ].…”

Anaerobic bacteria as a challenge for modern medical microbiological diagnostics

“…Bezwzględnych warunków beztlenowych (< 0,5% O 2 ) wymaga Fusobacterium nucleatum subsp. nucleatum oraz C. sporogenes [12]. Hodowla bakterii beztlenowych w warunkach laboratoryjnych prowadzona jest w temperaturze 37°C.…”

Clostridium cadaveris Osteomyelitis: an Unusual Pathogen which Highlights the Importance of Deep Tissue Sampling in Chronic Osteomyelitis

“…There are approximately 30 cases of Clostridial osteomyelitis published to date (Table 1 [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]). Of note, since 2016, Clostridioides difficile (previously Clostridium difficile) is considered a different genus based on phenotypic, chemotaxonomic and phylogenetic analysis [26] and so is not considered further here.…”

“…Osteomyelitis due to clostridial species usually follows trauma [14] or open fractures [7,8,11,12,[15][16][17][18], some obviously contaminated with soil [12,15,17] or sewerage [8,11]. In non-traumatic cases hosts may be immunocompromised by lymphoma [13,22] or diabetes [10], though sometimes there is neither a clearly identifiable source nor host risk factor [9]. Nine of these cases have been reported in the last five years which likely reflects laboratory advances in diagnostic capabilities including improved anaerobic culture techniques and the increasing availability of MALDI-TOF mass spectrometry and genetic sequencing for exact species determination.…”