Closure of a Tracheoesophageal Fistula by Bronchoscopic Application of Fibrin Glue and Decontamination of the Oral Cavity

Antonelli, Massimo; Cicconetti, F; Vivino, Gabriella; Gasparetto, A

doi:10.1378/chest.100.2.578

Cited by 35 publications

(7 citation statements)

References 6 publications

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“…Several beneficial effects have been described in clinics with the application of fibrin sealant preparations: reduction in air or fluid leakage from pulmonary parenchymal staple lines, reenforcement of esophageal anastomoses, closing of bronchopleural fistulas (especially those less than 4 mm in diameter), using a fiberoptic flexible bronchoscope, and treatment of pneumothorax using video-assisted surgical techniques. It has also been used for closure of trachoesophageal [46] and bronchopleural [47,48] fistulae by fiberoptic bronchoscopic application. The efficacy of fibrin sealant, in comparison with sutures alone, for avoiding bronchial and alveolar leakages after pulmonary resections was demonstrated in a prospective and randomized clinical trial [49].…”

Section: Thoracic Surgerymentioning

confidence: 99%

Fibrin Sealant: Scientific Rationale, Production Methods, Properties, and Current Clinical Use

Radosevich¹,

Goubran²,

Burnouf³

1997

Vox Sanguinis

191

127

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Fibrin sealant is a complex plasma-derived product which is increasingly used as a biodegradable tissue adhesive or sealant to stop or control bleeding or provide air and fluid tightness in many surgical situations. This review describes the historical development of current fibrin sealant preparations and the scientific rationale behind the alleged physiological benefits of its major plasma-derived components. A comparison in the extraction methods and viral reduction treatments applied to current commercial products and autologous preparations, and their respective advantages and limits, are discussed. Application devices used for surgical applications are described. A survey of the major clinical applications in various surgical areas is presented. Current issues in terms of viral safety, definition of optimal fibrin sealant composition, and regulatory concerns, especially to demonstrate clinical efficacy, are also included.

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Section: Thoracic Surgerymentioning

confidence: 99%

Fibrin Sealant: Scientific Rationale, Production Methods, Properties, and Current Clinical Use

Radosevich¹,

Goubran²,

Burnouf³

1997

Vox Sanguinis

191

127

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“…[1–6] More recently it has been investigated for cell delivery in tissue engineering applications where it is used to encapsulate cells. [7–12] Due to fibrin glue’s current clinical use and acceptance, the material has also gained attention as a possible means to deliver drug therapies.…”

Section: Introductionmentioning

confidence: 99%

Fibrin glue as a drug delivery system

Spicer

Mikos

2010

Journal of Controlled Release

163

107

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Fibrin glue has been used surgically for decades for hemostasis as well as a sealant. It has also been researched as both a gel for cell delivery and a vehicle for drug delivery. The drug delivery applications for fibrin glue span tissue engineering to chemotherapy and involve several mechanisms for drug matrix interactions and control of release kinetics. Additionally, drugs or factors can be loaded in the gel via impregnation and tethering to the gel through covalent linkages or affinity based systems. This review highlights recent research of fibrin glue as a drug delivery vehicle.

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“…[2][3][4] In the questionnaires, the parents of these children assessed that the sealing had been of lasting benefit. All 3 children also improved in terms of less mucus and coughing, and a decreased number of antibiotic courses for the lower airways infection.…”

Section: Resultsmentioning

confidence: 99%

“…The fistula tract was denuded, using a bead of silver nitrate on a steel rod in cases. [2][3][4][5] A biopsy forceps was used to abrade the tract in case 1, but the lack of success prompted a change to silver nitrate, which was expected to induce scarring more readily.…”

Section: Surgical Methodsmentioning

confidence: 99%

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Endoscopic Sealing of Tracheoesophageal Fistulae

Linder

2006

Journal of Bronchology

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Recurrent or persistent tracheoesophageal fistulae after repair of esophageal atresia are infrequent but troublesome to the patients. Endoscopic sealing is an attractive, minimally invasive solution to this challenge. The best access for endoscopic treatment is via the trachea under general anesthesia. A drawback of this approach is that the fistula is exposed to positive pressure ventilation during the procedure. The positive pressure can force the fistula open and may counteract the endoscopic closure. In the present series, an esophageal balloon was used to block the airflow through the fistula during the sealing of fistulae in 4 children. The fistula was successfully closed in 3 children. Four to 5 sessions of endoscopic sealing were found necessary to complete the closure. The fourth child had to abandon treatment while moving from the area. The results were compared with those of the last child treated before the esophageal balloon was introduced. Assessed from a questionnaire, the sealing had a lasting effect up to 4 years after the procedure.

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Closure of a Tracheoesophageal Fistula by Bronchoscopic Application of Fibrin Glue and Decontamination of the Oral Cavity

Cited by 35 publications

References 6 publications

Fibrin Sealant: Scientific Rationale, Production Methods, Properties, and Current Clinical Use

Fibrin Sealant: Scientific Rationale, Production Methods, Properties, and Current Clinical Use

Fibrin glue as a drug delivery system

Endoscopic Sealing of Tracheoesophageal Fistulae

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