Closure of Abdominal Wall Defects Using Acellular Dermal Matrix

An, Gary; Walter, Robert; Nagy, Kimberly

doi:10.1097/01.ta.0000068241.66186.00

Cited by 46 publications

(25 citation statements)

References 53 publications

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“…The peritoneal cavity was lavaged with sterile saline, and injected with rat stool slurry (0.25 mL). 18 The slurry was previously prepared by homogenizing 1 g of rat stool in 20 mL of normal saline. Using 7-0 polypropylene with over-and-over sutures, a 2.5 × 0.5 cm piece of either PEUU or PEUU/ PLGA-tet20 sheet was interposed within the incision space (PEUU n = 5, PEUU/PLGAtet20 n = 5).…”

Section: In Vivo Assessmentmentioning

confidence: 99%

Generating Elastic, Biodegradable Polyurethane/Poly(lactide-co-glycolide) Fibrous Sheets with Controlled Antibiotic Release via Two-Stream Electrospinning

et al. 2008

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Damage control laparotomy is commonly applied to prevent compartment syndrome following trauma but is associated with new risks to the tissue, including infection. To address the need for biomaterials to improve abdominal laparotomy management, we fabricated an elastic, fibrous composite sheet with two distinct submicrometer fiber populations: biodegradable poly(ester urethane) urea (PEUU) and poly(lactide-co-glycolide) (PLGA), where the PLGA was loaded with the antibiotic tetracycline hydrochloride (PLGA-tet). A two-stream electrospinning setup was developed to create a uniform blend of PEUU and PLGA-tet fibers. Composite sheets were flexible with breaking strains exceeding 200%, tensile strengths of 5-7 MPa, and high suture retention capacity. The blending of PEUU fibers markedly reduced the shrinkage ratio observed for PLGA-tet sheets in buffer from 50% to 15%, while imparting elastomeric properties to the composites. Antibacterial activity was maintained for composite sheets following incubation in buffer for 7 days at 37 °C. In vivo studies demonstrated prevention of abscess formation in a contaminated rat abdominal wall model with the implanted material. These results demonstrate the benefits derivable from a two-stream electrospinning approach wherein mechanical and controlled-release properties are contributed by independent fiber populations and the applicability of this composite material to abdominal wall closure.

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Section: In Vivo Assessmentmentioning

confidence: 99%

Generating Elastic, Biodegradable Polyurethane/Poly(lactide-co-glycolide) Fibrous Sheets with Controlled Antibiotic Release via Two-Stream Electrospinning

et al. 2008

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“…34 There are numerous, mostly experimental, reports on the application of ECM bioscaffolds in the repair and reconstitution of many soft tissue structures with variable success. Tissues include the lower urinary tract, [35][36][37] laryngeal cartilage, 38 esophagus, 39 abdominal wall, [40][41][42][43][44][45] diaphragm, 46,47 dura mater, 48 blood vessels, [49][50][51] tendons, [52][53][54][55][56] ligaments, 57,58 fascia, 59 menisci, [60][61][62][63] and bone. 64 Both commercially available ECM matrices on the veterinary market are promoted as implantable products to accelerate wound healing in dogs and cats.…”

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confidence: 99%

Effect of Porcine Small Intestinal Submucosa on Acute Full‐Thickness Wounds in Dogs

et al. 2008

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Objective-To evaluate the effects of porcine small intestinal submucosa (PSIS) on the healing of full-thickness wounds in dogs, specifically the appearance of granulation tissue, percent epithelialization and contraction, histologic variables of inflammation and repair, and aerobic culture results. Study Design-Prospective, controlled, experimental study. Animals-Purpose-bred, female dogs (n ¼ 10). Methods-Wounds were created bilaterally on the trunk; 1 side as a control and 1 treated with PSIS. First appearance of granulation tissue was recorded. Total wound area, open wound area, and epithelialized area were measured at 21 time points-wound contraction and percent epithelialization were calculated. Aerobic cultures were taken at 4 time points and wound biopsies at 8. Histologic features were graded into an Acute Inflammation Score and Repair Score. Results-There was no difference in first appearance of granulation tissue between PSIS-treated and control wounds. Wound contraction was significantly faster in control wounds as was percent epithelialization after day 21. Histologic Acute Inflammation Scores were significantly higher in PSIS-treated wounds compared with control wounds on days 2 and 6. There were no differences in Histologic Repair Scores between PSIS-treated and control wounds or in aerobic culture results. Conclusion-Wounds treated with PSIS contract more slowly, epithelialize less, and have more pronounced acute inflammation after implantation than control wounds. Clinical Relevance-Acute, full-thickness wounds in dogs do not benefit from treatment with PSIS. r

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“…The source of this material is dermis from human cadavers, processed to eliminate all cellular components in the dermal layer while retaining the extracellular matrix and basement membrane. The extracellular matrix frame formation promotes growth of fibroblasts and collagen deposits and maturation, and these changes occur when the material is implanted in the human body (Sclafani et al, 2002;An et al, 2004;Silverman et al, 2004). Complete preservation of the extracellular matrix and progressive blood supply reconstruction allow the material to keep its own structure and differentiate into autologous tissue at the same time.…”

Section: Discussionmentioning

confidence: 99%

A retrospective analysis of surgical treatment of mesh infection after repair of ventral hernia or defect

Fd¹,

Jy²,

Yao³

et al. 2015

Genet. Mol. Res.

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Closure of Abdominal Wall Defects Using Acellular Dermal Matrix

Abstract: Acellular dermal matrix exhibits a number of favorable features relative to PTFE for closing sterile or contaminated full-thickness abdominal wall defects.

Cited by 46 publications

References 53 publications

Generating Elastic, Biodegradable Polyurethane/Poly(lactide-co-glycolide) Fibrous Sheets with Controlled Antibiotic Release via Two-Stream Electrospinning

Generating Elastic, Biodegradable Polyurethane/Poly(lactide-co-glycolide) Fibrous Sheets with Controlled Antibiotic Release via Two-Stream Electrospinning

Effect of Porcine Small Intestinal Submucosa on Acute Full‐Thickness Wounds in Dogs

A retrospective analysis of surgical treatment of mesh infection after repair of ventral hernia or defect

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