Closure to “Refined Numerical Scheme for Advective Transport in Diffusion Simulation” by T. Komatsu, K. Ohgushi, and K. Asai

Komatsu, Toshimitsu; Ohgushi, Koichiro; Asai, Keisuke

doi:10.1061/(asce)0733-9429(1998)124:7(767)

Cited by 8 publications

(14 citation statements)

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“…A similar. sporadic complementation of cell killing without correction of RDS has been observed with DNA-mediated gene transfer into AT cells [36,38-401. or after cell fusion of AT cells with normal human cells [41], or in AT cells containing an extra copy of human chromosome 1 I [36,41]. Comparable results have been observed with DNA-mediated gene transfer into the AT-like V-E5 hamster cells [28].…”

Section: Discussionmentioning

confidence: 96%

The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes

Jongmans

Verhaegh²,

Jaspers

et al. 1996

Mutation Research/DNA Repair

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X-ray-sensitiveChinese hamster V79 cells mutants, V-C4, V-E5 and V-G8, show an abnormal response to X-ray-induced DNA damage. Like ataxia telangiectasia (AT) cells, they display increased cell killing, chromosomal instability and a diminished inhibition of DNA synthesis following ionizing radiation. To localize the defective hamster gene ( XrZCCS) on the human genome, human chromosomes were introduced into the AT-like hamster mutants, by microcell mediated chromosome transfer. Although, none of the human chromosomes corrected the defect in these mutants, the defect was corrected by a single mouse chromosome, derived from the A9 microcell donor cell line. In four independent X-ray-resistant microcell hybrid clones of V-E.5, the presence of the mouse chromosome was determined by fluorescent in situ hybridization, using a mouse cot-l probe. By PCR analysis with primers specific for different mouse chromosomes and Southern blot analysis with the mouse Mlr probe, the mouse chromosome 9, was identified in all four X-ray-resistant hybrid clones. Segregation of the mouse chromosome 9 from these hamster-mouse microcell hybrids led to the loss of the Research 364 (19961 91-102 regained X-ray-resistance, confirming that mouse chromosome 9 is responsible for complementation of the defect in V-E.5 cells. The assignment of the mouse homolog of the ATM gene to mouse chromosome 9. and the presence of this mouse chromosome only in the radioresistant hamster cell hybrids suggest that the hamster AT-like mutants are homologous to AT. although they are not complemented by human chromosome I I.

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Section: Discussionmentioning

confidence: 96%

The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes

Jongmans

Verhaegh²,

Jaspers

et al. 1996

Mutation Research/DNA Repair

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“…Ibuprofen synthesis was investigated by Komatsu andc oworkers [88] in the beginning of the 1990s as at arget for an itrilase-catalyzed reaction alternative to the conventionalc hemical methods. The retrosynthetic analysis for this well-known molecule shows the formation of the chiral carboxylic acid 159 comingf rom the selective hydrolysis of the corresponding nitrile 160,w hich could be formed by as equence of steps,s tarting from isobutyl benzene 161.F ollowing this strategy,t he authors have synthetized the desired nitrile derivative 162 and tested ap urified nitrilase obtained from ac ell extract of Acinetobacter sp.…”

Section: Baeyer-villiger Monooxygenasesmentioning

confidence: 99%

“…Ibuprofen retroanalysis followed by the use of an Acinetobacter species AK 226 nitrilase. [88] Scheme26. Nitrilase approach towards Atorvastatin synthesis.…”

Section: Aldolasesmentioning

confidence: 99%

A Retrosynthesis Approach for Biocatalysis in Organic Synthesis

Souza

Miranda

Bornscheuer

2017

Chemistry A European J

193

104

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For the planningo fa no rganic synthesis route, the disconnection approach guided by retrosynthetic analysis of possible intermediates and the chemical reactions involved, backt or eady available starting materials, is well established. In contrast, such concepts just get developed for biocatalytic routes. In this Review we highlightf unctional group interconversions catalyzed by enzymes. The article is organized rather by chemical bonds formed-exemplified for CÀN, CÀO-and CÀC-bonds-and not by enzyme classes, covering ab road range of reactions to incorporate the desired functionality in the target molecule. Furthermore, the successful use of biocatalysts, also in combination with chemicals teps, is exemplified for the synthesis of various drugs and advanced pharmaceutical intermediates such as Crispine A, Sitagliptina nd Atorvastatin. This Reviewa lso provides some basic guidelines to choose the most appropriate enzyme for at argeted reaction keepingi nm ind aspects like commercial availability,c ofactor-requirement, solventt olerance, use of isolated enzymes or whole cell recombinant microorganisms aiming to assist organic chemists in the use of enzymesf or synthetic applications.

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“…However, it is more difficult to devise numerical schemes of sufficient accuracy for solving the advection process (Li, 1990;Schohl and Holly, 1991). Among the procedures for solving the pure advection equation, several schemes were proposed, such as the Holly and Preissmann (1977) two-point fourth order scheme; the six-point scheme (Komatsu et al, 1985); the improved six-point scheme (Komatsu et al, 1989); the time-line interpolation scheme (Yang and Hsu, 1990); the spatial cubic spline scheme (Schohl and Holly, 1991); the SOWMAC scheme (Komatsu et al, 1992(Komatsu et al, , 1997 and the time line cubic spline scheme (Ahmad and Kothyari, 2001). The diffusion process can be accurately computed by several numerical schemes such as Crank-Nicholson central difference scheme; the Crank-Nicholson Galerkin finite-element method; or the alternate-direction implicit (ADI) scheme of Smith (1978).…”

Section: Introductionmentioning

confidence: 99%

Two-dimensional mixing of pollutants in streams with transverse line source

Singh

Ahmad

Kothyari

2009

Journal of Hydraulic Research

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A numerical scheme based on the split-operator approach was developed for the solution of two-dimensional mixing equation with a transverse line-slug source in open channels. An exact solution of the advection equation was developed by adopting the Courant number equal to unity for the computational nodes lying on the flow surface. For the other computational nodes, the cubic spline interpolation scheme was utilized. The computation of the diffusion rate involved the alternate-direction implicit method. The scheme was illustrated by hypothesizing the transverse line injection of tracer at the flow surface, at mid-depth and at the channel bed; it was found that the numerical model is mass conservative. The scheme was validated by comparing its results with Fischer's analytical solution for one-dimensional mixing, the analytical solution by Lipsett and Beltaos for a continuous injection of pollutant as a steady transverse line source, and the laboratory data for slug injection. RÉSUMÉUn schéma numérique basé sur une approche de fractionnement des opérateurs a été développé pour résoudre l'équation bidimensionnelle de mélange à partir d'une source transversale dans des canaux ouverts. Une solution exacte de l'équation d'advection a été développée en adoptant un nombre de Courant égal à l'unité pour les noeuds du maillage de calcul se trouvant sur la surface de l'écoulement. Pour les autres noeuds, on a utilisé le schéma d'interpolation par fonction spline cubique. Le calcul du taux de diffusion a été réalisé avec la méthode implicite des directions alternées. Pour illustrer le modèle, on a adopté trois positions de la ligne transversale d'injection du traceur: en surface de l'écoulement, à mi-profondeur, et en fond de canal; on peut constater que le modèle numérique est conservatif en masse. Une validation a été réalisée en comparant les résultats du modèle à la solution analytique de Fischer pour le mélange unidimensionnel, à la solution analytique de Lipsett et Beltaos pour une injection continue de polluant par une ligne source transversale permanente, et aux données de laboratoire pour une injection en ligne. longitudinal mixing occurs in the far-field region. Dumping of pollutants across the streams from a bridge, or the disposal of hot water from thermal power plants into a stream, or the bursting of a pipe carrying pollutants across a water body (Khan et al., 2007) resemble to the process of transverse line slug mixing in streams.Even though vertical mixing is limited to near the pollutant source, its understanding is essential for determining the concentration of the pollutant in the far-field region. The profiles of pollutant concentration at the end of the near-field region serve the purpose of boundary conditions to the models for a mixing simulation in the mid-or the far-field. The process of longitudinal dispersion, i.e., mixing in the far-field region has been studied in detail (Singh et al., 1992;Ahmad et al., 2004). In present study, therefore, the process of two-dimensional mixing, i.e., mixing in t...

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Closure to “Refined Numerical Scheme for Advective Transport in Diffusion Simulation” by T. Komatsu, K. Ohgushi, and K. Asai

Cited by 8 publications

References 1 publication

The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes

The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes

A Retrosynthesis Approach for Biocatalysis in Organic Synthesis

Two-dimensional mixing of pollutants in streams with transverse line source

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