Clothianidin alters leukocyte profiles and elevates measures of oxidative stress in tadpoles of the amphibian, Rana pipiens

Robinson, Stacey A.; Chlebak, Ryan J.; Young, Sarah D.; Dalton, Rebecca L.; Gavel, Melody J.; Prosser, Ryan S.; Bartlett, Adrienne J.; Solla, Shane R. de

doi:10.1016/j.envpol.2021.117149

Cited by 20 publications

(7 citation statements)

References 52 publications

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“…With respect to anuran metamorphosis, delays in completion have been reported for Xenopus laevis exposed to 20 and 100 mg/L of TIA and clothianidin (Jenkins et al, 2021), Lithobates pipiens tadpoles exposed to 8.5 mg/L and 250 ng/L of IMI (Moe et al, 2007), and Lithobates sylvaticus tadpoles exposed to 1 µg/L, 10 µg/L and 100 µg/L of IMI, although, in this case, the same concentrations of TIA had no effect on development time (Robinson et al, 2017). A lack of effect on development time was also reported for tadpoles of Acris blanchardi, Lithobates clamitans and Hyla chrysosceli exposed to 1 mg/L of IMI (Boone, 2018), Rana pipiens exposed to 2.5 and 250 ug/L of clothianidin and TIA (Robinson et al, 2019), and to 0,23, 1, 10 and 100 µg/L of clothianidin (Robinson et al, 2021). Finally, larvae of the Northwestern salamander (Ambystoma gracile) presented, in contrast, accelerated development, when exposed to 100 μg/L of IMI (Danis and Marlatt, 2021).…”

Section: Introductionsupporting

confidence: 61%

“…Sublethal exposures of frogs and sh to TIA and IMI have been shown to affect red and white blood cell counts (Gavel et al, 2019;Paunescu et al, 2022), endocrine systems (Lifei et al, 2019;Gavel et al 2019;Crayton et al, 2020), glycogenesis and blood glucose levels (Stoyanova et al, 2015;Vieira et al, 2018;Paunescu et al, 2022), oxidative stress and antioxidant response (Yan et al, 2015;Vieira et al, 2018), the escape response to predators (Lee-Jenkins y Robinson, 2018;Sweeney et al, 2020), as well as DNA damage and genotoxicity (Feng et al, 2004;Perez-Iglesias et al, 2014Yan et al, 2015;Iturburu et al, 2017;Moe, 2017;Vieira et al, 2018). For its part, clothianidin was found to induce oxidative stress and alter the leukocyte pro le in tadpoles of the frog Rana pipiens (Gavel et al, 2019;Robinson et al 2021); although it did not affect the susceptibility of larval leopard frogs to infection by trematode parasites (Robinson et al, 2019).…”

Section: Introductionmentioning

confidence: 98%

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Toxicity of the neonicotinoid insecticides thiamethoxam and imidacloprid on tadpoles of four species of South American amphibians and effects of thiamethoxam on the metamorphosis of Rhinella arenarum

Peña

Natale

Brodeur

2022

Preprint

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The present study examined the acute and chronic toxicity of the neonicotinoid insecticides imidacloprid and thiamethoxam in neotropical amphibian species from the Pampa region of Argentina. The median lethal concentration after 96h of exposure (96h-LC50) ranged between 11.28 and > 71.2 mg/L amongst all species and development stages tested; indicating that these pesticides are unlikely to cause acute toxicity in the wild. The subchronic toxicity was also low, with 21d-LC50 values ranging between 27.15 and > 71.2 mg/L. However, exposure of developing tadpoles of Rhinella arenarum to thiamethoxam from stage 27 until the completion of metamorphosis showed that treated animals present a significant reduction in metamorphic success together with a smaller size at metamorphosis and an asymmetry in the length of the left and right front arms. These effects, which are observed starting from the lowest concentration tested (9 mg/L), suggest an effect of thiamethoxam on the hypothalamic-pituitary-thyroid (HPT) axis. Given that the observed effects can clearly impair amphibian performance and survival in the wild, further studies employing the same experimental approach but looking at lower environmentally-relevant concentrations are needed.

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Section: Introductionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 98%

Toxicity of the neonicotinoid insecticides thiamethoxam and imidacloprid on tadpoles of four species of South American amphibians and effects of thiamethoxam on the metamorphosis of Rhinella arenarum

Peña

Natale

Brodeur

2022

Preprint

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“…No differences in development, survival, growth time or hepatosomatic index in model organisms were observed. The research workers here concluded that Rana pipiens revealed increased stress response however unclear concentration-response relation is unable to mention the effect on the overall health of these organisms [106].…”

Section: The Potential Adverse Effects Of Neonicotinoid Insecticides On Aquatic Vertebratesmentioning

confidence: 64%

Physiological Effects of Neonicotinoid Insecticides on Non-Target Aquatic Animals—An Updated Review

Malhotra

Chen

Huang

et al. 2021

IJMS

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In this paper, we review the effects of large-scale neonicotinoid contaminations in the aquatic environment on non-target aquatic invertebrate and vertebrate species. These aquatic species are the fauna widely exposed to environmental changes and chemical accumulation in bodies of water. Neonicotinoids are insecticides that target the nicotinic type acetylcholine receptors (nAChRs) in the central nervous systems (CNS) and are considered selective neurotoxins for insects. However, studies on their physiologic impacts and interactions with non-target species are limited. In researches dedicated to exploring physiologic and toxic outcomes of neonicotinoids, studies relating to the effects on vertebrate species represent a minority case compared to invertebrate species. For aquatic species, the known effects of neonicotinoids are described in the level of organismal, behavioral, genetic and physiologic toxicities. Toxicological studies were reported based on the environment of bodies of water, temperature, salinity and several other factors. There exists a knowledge gap on the relationship between toxicity outcomes to regulatory risk valuation. It has been a general observation among studies that neonicotinoid insecticides demonstrate significant toxicity to an extensive variety of invertebrates. Comprehensive analysis of data points to a generalization that field-realistic and laboratory exposures could result in different or non-comparable results in some cases. Aquatic invertebrates perform important roles in balancing a healthy ecosystem, thus rapid screening strategies are necessary to verify physiologic and toxicological impacts. So far, much of the studies describing field tests on non-target species are inadequate and in many cases, obsolete. Considering the current literature, this review addresses important information gaps relating to the impacts of neonicotinoids on the environment and spring forward policies, avoiding adverse biological and ecological effects on a range of non-target aquatic species which might further impair the whole of the aquatic ecological web.

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“…Results of this study indicated that inhalation imidacloprid for 60 days causes pathophysiological changes in the liver, These changes are likely caused by damage to the hepatocytes' membrane permeability, which allows this enzyme and pesticide to leak out and disrupt the normal structure of the hepatocellular membrane. Exposure to pesticides lead to liver damage and leakage of cytosolic enzymes from hepatocytes and other body organs into blood [17]. These enzymes are important and critical enzymes in the biological processes as the breakdown of amino acids into α keto-acids and are responsible for the detoxification process, metabolism, and biosynthesis of energetic macromolecules for different essential functions [18].…”

Section: Liver Function Parametersmentioning

confidence: 99%

Effect of Inhalation Exposure to Nano-Imidacloprid on Liver and Kidney Functions In Male Rats

Ahmood Al-Janabi,

Abdulhay

2024

IOP Conf. Ser.: Earth Environ. Sci.

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Pesticide poisoning is a serious global public health issue and is responsible for a sizable number of annual fatalities. This study was designed to examine the potentially harmful effects of adult rats being exposed to imidacloprid (IMD) as a nanoparticle by determining the chronic effect of inhalation of (5,10 and 20) mg/kg/b.w. of nano-imidacloprid for a duration of 60 days. The most important biochemical parameters of the serum liver function parameters were aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase ALP, kidney function [blood urea, creatinine, and urea], and oxidative stress parameters (MDA, GSH, and CAT) in all treated groups when compared to the control group. The exposure caused a highly significant decrease (P≤0.05) for (AST) and (ALT). No significant changes were observed, while a highly significant decrease was recorded for (ALP) in all treatments with nano-imidacloprid compared with the control. On the other hand, a highly significant decrease in blood urea, creatinine, and uric acid was recorded in all groups treated with nano-imidacloprid compared with the control. Oxidative stress parameters revealed a highly significant (P≤0.05) increase in malondialdehyde (MDA) after 60 days of exposure and a decline in reduced glutathione (GSH) and catalase activity CAT.

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Clothianidin alters leukocyte profiles and elevates measures of oxidative stress in tadpoles of the amphibian, Rana pipiens

Cited by 20 publications

References 52 publications

Toxicity of the neonicotinoid insecticides thiamethoxam and imidacloprid on tadpoles of four species of South American amphibians and effects of thiamethoxam on the metamorphosis of Rhinella arenarum

Toxicity of the neonicotinoid insecticides thiamethoxam and imidacloprid on tadpoles of four species of South American amphibians and effects of thiamethoxam on the metamorphosis of Rhinella arenarum

Physiological Effects of Neonicotinoid Insecticides on Non-Target Aquatic Animals—An Updated Review

Effect of Inhalation Exposure to Nano-Imidacloprid on Liver and Kidney Functions In Male Rats

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