Cloud Point and Dye Solubilization Studies of Amphiphilic Drug Solutions: The Effect of Electrolytes and Nonelectrolytes

Kim, Eui Jung; Kim, Sunwook; Yoo, Ik‐Keun; Chung, Jin Suk; Kim, Jae Seong; Shah, Dinesh O.

doi:10.1080/00986440500352014

Cited by 14 publications

(11 citation statements)

References 30 publications

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“…In the presence of glucose/fructose, the solubility, as well as the micellar size of TX-100, was reduced. 25,26 Maclay found the variation of the CP of TX-100 as a function of polyols concentration to be reduced with the upsurge of polyols concentration. 27 In our current study, we also observed a similar result; that is, the CP values of TX-100 were found to decrease with the augmentation of the glucose/fructose concentration (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

Clouding and Thermodynamic Characteristics of Triton X-100 in the Presence of Ciprofloxacin Hydrochloride: Influence of Polyols

2019

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Herein, the cloud point (CP) measurement of Triton X-100 (TX-100) in aqueous/polyols medium has been performed in the absence/presence of ciprofloxacin hydrochloride (CFH) antibiotic drug and demonstrated in detail. The executed CP values of TX-100 in H2O/polyols were obtained to be decreased with an increase of concentration of TX-100 up to a certain value, and then increased with the further increase of the concentration of TX-100. The CP values were reduced in the presence of CFH in all cases. The obtained CP values of TX-100 were lower in the presence of polyols as compared to that in an aqueous medium and reduced further with the subsequent rise of the polyols concentration. The Gibbs free energy of clouding (ΔG c 0) was positive in all cases. The enthalpy of clouding (ΔH c 0) and entropy of clouding (ΔS c 0) as well as transfer properties of the clouding of TX-100 were evaluated in aqueous/polyols media in the absence/attendance of CFH and discussed thoroughly. The more spontaneous clouding phenomenon in the presence of polyols is indicated by the negative value of free energy of transfer (ΔG c,tr 0). The entropy–enthalpy compensation was observed in all cases studied.

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Section: Resultsmentioning

confidence: 99%

Clouding and Thermodynamic Characteristics of Triton X-100 in the Presence of Ciprofloxacin Hydrochloride: Influence of Polyols

2019

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“…Polyols may reduce the solubility of TX-100 and reduce the micelle size. 31,32 Lowering of CP values of the TX-100 + PEG-400 mixture by polyols is a linear function of the polyol concentration reported by Maclay. 33 From Table 3 and Figure S1 (Supporting Information), it is found that the addition of polyols to the PEG-400 + TX-100 mixture reduces the CP of the mixture to a small extent with the exception.…”

Section: Resultsmentioning

confidence: 83%

Physicochemical Observation of the Impact of Various Additives on the Clouding Nature of Triton X-100 Solution

et al. 2020

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Herein, measurements of the cloud point (CP) of Triton X-100 (TX-100)/ TX-100 + polyethylene glycol-400 (PEG-400) systems were carried out in aqueous/additive solutions. For the clouding process of TX-100 in H 2 O, the CP values were observed to be reduced first by means of enhancing the TX-100 content up to a fixed level and then increased with increasing content. The CP values of TX-100 were observed to be increased in the presence of PEG-400 and the CP values were further enhanced with enhancing content of PEG-400 in the aqueous medium. In the case of the aqueous solution of alcohol, the CP values of TX-100 solution in the presence and absence of PEG-400 were almost reduced with increasing chain length of alcohols used. For TX-100 + PEG-400 mixed systems, the observed CP values were found to be reduced to a small extent with increasing content of polyols (glucose, galactose, and maltose) and follow the following order: glucose ≈ galactose > maltose. The CP values of TX-100 + PEG-400 mixed systems were observed to be reduced with enhancing contents of diols used. The impact of various diols on increasing CP values of the TX-100 + PEG-400 system was observed in the subsequent trend: 1,2-propanediol > 1,2ethanediol. The clouding phenomena of the TX-100 + PEG-400 system were observed to be delayed with enhancing the extent of urea.

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“…A great deal of research has been conducted on CP determination by visual methods in the past decade. ,,,,, Recent work on the clouding phenomenon and other related parameters of drugs ceftriaxone sodium trihydrate and the phenothiazine family reported in the literature have also used the same method for CP determination. − It is known that the clouding behavior of drugs depends on the solvation or desolvation equilibrium existence. The presence of additives in water and in EtOH–WR mixed media can change such an equilibrium, and as a result, the CP of the drug solutions may vary significantly.…”

Section: Resultsmentioning

confidence: 99%

“…Amphiphilic molecules consist of hydrophobic tails and hydrophilic headgroups. They self-assemble to form well-defined aggregates by way of hydrophobic interaction within the nonpolar hydrocarbon part, and the electrostatic interaction of the polar or ionic headgroups and the aggregates thereby formed are called micelles. , The self-assembly in these associated colloids is a natural and spontaneous process which comes into play as a result of noncovalent interactions such as van der Waals, electrostatic, hydrogen bonding, and hydrophilic/hydrophobic interactions …”

Section: Introductionmentioning

confidence: 99%

“…The clouding of such system is a reversible process, and the phenomenon occurs due to the subtle balance in the interactions between hydrophobic and hydrophilic groups . During clouding, the physical change of phase separation from the aqueous phase as a result of the weakening of hydrogen bonds between the amphiphile and water molecules occurs, resulting in the formation of dilute surfactant and coacervate phases. ,, The CP is considered to be a critical parameter in several applications such as wetting, cleaning, and foaming, and this technique is utilized in surfactant-based extraction processes of organic compounds and proteins . The worth of the clouding system lies in the fact that it generates a safe environment for the extraction of cells or protein where it will not be damaged and can be used as a new nonaqueous medium for the biocatalysis and biotransformation processes.…”

Section: Introductionmentioning

confidence: 99%

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Phase Separation of Amphiphilic Drug Amitriptyline Hydrochloride in the Presence of Additives: Role of Ethanol

Gurung

Pulikkal

2018

J. Chem. Eng. Data

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In this work, the effect of ethanol (EtOH) at different weight percentages (wt %) (0, 5, 10, and 15% w/w) is accounted for in the clouding phenomena of the AMT drug with/without additives (inorganic salts and conventional and gemini surfactants). The critical micelle concentration (cmc) and degree of counterions dissociation (α) of AMT solution at 30 °C in SP buffer (pH 6.7), studied through conductometric studies, are found to be enhanced with the increase in ethanol content due to the reduction in the dielectric constant of mixed media. A dye solubilization study performed under identical physicochemical conditions exhibited supporting results. Clouding could not be observed in 20 wt % EtOH−WR mixed media at pH 6.7. The effects of additives on the CP in 15 wt % EtOH−WR at a pH of 6.95 were also studied. Furthermore, the effect of pH (range 6.7 to 7.15) on the CP in the presence of KCl at the same composition of the mixed media reduce the clouding temperature due to the deprotonation of AMT headgroups. For up to 10 wt % EtOH−WR mixed media, the effect of anionic and cationic co-ions on the CP is found to follow the order Br − > Cl − > F − and NH 4 + > Li + > Na + > K + , respectively. When surfactants were used as additives, the hydrophobicity was found to be responsible for higher CP values and follow the order TTAB < CTAB < 14-m-14, where m is the length of the spacer.

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Cloud Point and Dye Solubilization Studies of Amphiphilic Drug Solutions: The Effect of Electrolytes and Nonelectrolytes

Cited by 14 publications

References 30 publications

Clouding and Thermodynamic Characteristics of Triton X-100 in the Presence of Ciprofloxacin Hydrochloride: Influence of Polyols

Clouding and Thermodynamic Characteristics of Triton X-100 in the Presence of Ciprofloxacin Hydrochloride: Influence of Polyols

Physicochemical Observation of the Impact of Various Additives on the Clouding Nature of Triton X-100 Solution

Phase Separation of Amphiphilic Drug Amitriptyline Hydrochloride in the Presence of Additives: Role of Ethanol

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