Cloudy apple juice protects against chemical-induced oxidative stress in rat

Kujawska, Małgorzata; Ignatowicz, Ewa; Ewertowska, Małgorzata; Markowski, J.; Jodynis‐Liebert, Jadwiga

doi:10.1007/s00394-010-0114-y

Cited by 23 publications

(17 citation statements)

References 34 publications

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“…Apple and their derivatives have shown important antioxidant activity [33,34] due to the presence of flavonoids (catechins, flavonols, quercetin), phenolic acids (quercetin glycosides, catechin, epicatechin, procyanidins), vitamins and fibers [15], which have been described as contributors to human health against cardiovascular diseases, asthma and pulmonary dysfunction, diabetes, obesity and cancer [35].…”

Section: Discussionmentioning

confidence: 99%

Apple juice attenuates genotoxicity and oxidative stress induced by cadmium exposure in multiple organs of rats

Moura

Ribeiro

Lucke

et al. 2015

Journal of Trace Elements in Medicine and Biology

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Section: Discussionmentioning

confidence: 99%

Apple juice attenuates genotoxicity and oxidative stress induced by cadmium exposure in multiple organs of rats

Moura

Ribeiro

Lucke

et al. 2015

Journal of Trace Elements in Medicine and Biology

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“…Prevention from oxidative stress plays a beneficial role in the development of many process related to free radical production such as degenerative diseases and mutagenesis or the action of certain drugs whose metabolism induces the formation of reactive oxygen species. The intake of a diet rich in antioxidant compounds can prevent some oxidative-related disorders and organ toxicity events either directly neutralizing reactive oxygen species (Kujawska et al, 2011) or modulating gene expression that contributes to oxidative stress (Soyalan et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Dried apple enriched with mandarin juice counteracts tamoxifen-induced oxidative stress in rats

Codoñer‐Franch

Betoret

López-Jaén

et al. 2013

International Journal of Food Sciences and Nutrition

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Codoñer Franch, P.; Betoret Valls, ME.; López Jaén, AB.; Betoret Valls, N.; Fito Maupoey, P.; Valls Bellés, MV. (2013). Dried apple enriched with mandarin juice counteracts tamoxifen induced oxidative stress in rats. International Journal of Food Sciences and Nutrition. 64(7): 815-821. doi:10.3109/09637486.2013.798267. Dried apple enriched with mandarin juice by vacuum impregnation counteracts the liver oxidative effect of tamoxifen in rats. AbstractWe have investigated the effects of a product made of apple dehydrated enriched by vacuum impregnation of mandarin juice in decreasing oxidative stress biomarkers in rat induced liver injury by tamoxifen. A experimental design was undertaken in six groups of animals. One group fed a standard diet. Two groups were supplemented with 0.745 g/d of apples snacks/day either impregnated or not with mandarin juice during 28 days. Three groups of rats were treated with tamoxifen 1.54 mg/kg/day during 21 days; of these, one group was supplemented with the apple snacks and the other with the apple snacks impregnated with mandarin juice. Plasma aminotransferases were determined as index of hepatocellular damage and interleukin-6 as measure of inflammation. Plasma and liver carbonyl groups, indicative of protein oxidation, and α-tocopherol as evaluation of antioxidant defense were measured. The modified base 8-hydroxydexyguanosine as indicative of DNA damage was determined in liver. Tamoxifen induced an increase in aminotranferases and both plasma and liver markers of oxidative stress and DNA damage that decrease significantly after apple snack consumption; in most of cases they even reach normal values as those achieved previous to induce the injury with tamoxifen. The effect of the mandarin juice incorporated to the structure of apple mainly accounts for increasing levels of α-tocopherol in plasma and liver. The present study shown the potential protective action of the products made of dehydrated apple either impregnated or not with mandarin juice by vacuum impregnation for counteracting the chemically induced liver injury in rats.

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“…Thus, the action of this food product might be to down regulate ongoing oxidative stress and/or inflammatory processes induced by TAM, allowing for the recovery of function of cellular homeostasis. In the present experiment, we have demonstrated that the supplementation with apple snacks markedly attenuated hepatic protein and DNA oxidation induced by the xenobiotic, which is consistent with welldocumented in vitro free radical-scavenging ability and antioxidant activity of the apple products (Kujawska et al, 2011).…”

Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Desarrollo Tecnológico Y Valoración Funcional De Aperitivos De Manzana Y Zumo De Mandarina. Efecto Antioxidante en Niños Obesos Y Efecto Probiótico Contra La Infección Por Helicobacter Pylori en Niños

Valls¹,

Ester²

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reúne las condiciones adecuadas para constituir su tesis doctoral, por lo que AUTORIZAN a la interesada para su presentación. Valencia, Diciembre 2012Fdo. Dr. Pedro Fito Maupoey Fdo. Dra. Noelia Betoret VallsDirector de la tesis Directora de la tesis Arribat este moment vull agrair-vos tot el que heu fet per mí:A Pere gràcies per donar-me l´oportunitat i el suport necessari per començar i acabar esta tesis. A Noe gràcies per tot. Pel suport incondicional, les paraules d´ànim i l´esforç compartit. Perquè hem sigut un gran equip i ho hem fet juntes. Als meus pares gràcies perquè sense el seu esperit d´esforç i sacrifici jo no haguera pogut arribar fins ací i perquè m´ensenyaren des de ben menuda que les coses costen i és necessari treballar dur per aconseguir-les.A Rosario gràcies per ser molt més que una companya de doctorat i perquè sempre trobà el moment per escoltar-me. I com no, a Marek, per aguantar-me molt i estimar-me més i perquè sense dubte el millor de tot açò ha sigut trobar-lo. Moltes gràcies a tots!!! RESUMENEn la presente tesis doctoral se ha llevado a cabo el desarrollo tecnológico y la valoración funcional, mediante estudios in vivo, de aperitivos de manzana y zumo de mandarina desarrollados utilizando la técnica de impregnación a vacío. Concretamente, se han desarrollado dos alimentos, uno con efecto sobre el riesgo cardiovascular en niños obesos de edad escolar y otro con efecto contra la infección por Helicobacter pylori también en niños de edad escolar. La investigación, de marcado carácter interdisciplinar, se ha llevado a cabo en colaboración con el Departamento de Ciencia de los Alimentos del Instituto de Agroquímica y Tecnología de Alimentos (IATA, CSIC), con el Departamento de Ginecología y Obstetricia de la Universidad de Valencia y con el Servicio de Pediatría del Hospital Universitario Dr. Peset de Valencia.En primer lugar, se llevó a cabo una revisión bibliográfica que permitió analizar la situación actual y la evolución en los últimos años de las tecnologías utilizadas en el desarrollo de alimentos funcionales. Las tecnologías implicadas en el desarrollo de alimentos funcionales han cambiado, aumentando considerablemente aquellas tecnologías que forman una estructura capaz de prevenir el deterioro de los componentes fisiológicamente activos. La revisión bibliográfica ha dado lugar a la publicación del artículo "Functional foods development: Trends and technologies", que se incluye en el apartado de resultados, publicado en la revista "Trends in Food Science & Technology" de Elsevier con un índice de impacto 3.672 y se encuentra dentro de los 5 artículos más descargados desde septiembre de 2011.En segundo lugar, se diseñó una planta piloto que permitió fabricar el alimento funcional en cantidades suficientes para poder llevar a cabo los estudios in vivo realizados en esta tesis. Si bien no se ha llevado a cabo el escalado a nivel industrial, supone un primer paso para ello y además, se ha desarrollado un modelo matemático en el que se establecen las relaciones entre todas las variable...

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Cloudy apple juice protects against chemical-induced oxidative stress in rat

Abstract: Phytochemicals in commonly consumed apple juice may protect some macromolecules against oxidative insult induced by xenobiotics.

Cited by 23 publications

References 34 publications

Apple juice attenuates genotoxicity and oxidative stress induced by cadmium exposure in multiple organs of rats

Apple juice attenuates genotoxicity and oxidative stress induced by cadmium exposure in multiple organs of rats

Dried apple enriched with mandarin juice counteracts tamoxifen-induced oxidative stress in rats

Desarrollo Tecnológico Y Valoración Funcional De Aperitivos De Manzana Y Zumo De Mandarina. Efecto Antioxidante en Niños Obesos Y Efecto Probiótico Contra La Infección Por Helicobacter Pylori en Niños

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